Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells.

Research output: Contribution to journal › Journal article › Research › peer-review

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Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells. / Kapoor, Sarika; Marwaha, Ram; Majumdar, Siddhartha; Ghosh, Sujata.

In: Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis, Vol. 32, No. 4, 2007, p. 559-67.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kapoor, S, Marwaha, R, Majumdar, S & Ghosh, S 2007, 'Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells.', Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis, vol. 32, no. 4, pp. 559-67. https://doi.org/10.1016/j.leukres.2007.08.007

APA

Kapoor, S., Marwaha, R., Majumdar, S., & Ghosh, S. (2007). Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells. Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis, 32(4), 559-67. https://doi.org/10.1016/j.leukres.2007.08.007

Vancouver

Kapoor S, Marwaha R, Majumdar S, Ghosh S. Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells. Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 2007;32(4):559-67. https://doi.org/10.1016/j.leukres.2007.08.007

Author

Kapoor, Sarika ; Marwaha, Ram ; Majumdar, Siddhartha ; Ghosh, Sujata. / Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells. In: Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 2007 ; Vol. 32, No. 4. pp. 559-67.

Bibtex

@article{cea0dbd0accb11ddb538000ea68e967b,
title = "Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells.",
abstract = "Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAcalpha(2-->3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders ({"}Controls{"}). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgG(MAA). Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.",
author = "Sarika Kapoor and Ram Marwaha and Siddhartha Majumdar and Sujata Ghosh",
note = "Keywords: Apoptosis; Blotting, Western; Cell Line; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Glycoproteins; Humans; Lymphocytes; Male; Neuraminidase; Phytohemagglutinins; Precursor Cell Lymphoblastic Leukemia-Lymphoma",
year = "2007",
doi = "10.1016/j.leukres.2007.08.007",
language = "English",
volume = "32",
pages = "559--67",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Pergamon Press",
number = "4",

}

RIS

TY - JOUR

T1 - Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells.

AU - Kapoor, Sarika

AU - Marwaha, Ram

AU - Majumdar, Siddhartha

AU - Ghosh, Sujata

N1 - Keywords: Apoptosis; Blotting, Western; Cell Line; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Glycoproteins; Humans; Lymphocytes; Male; Neuraminidase; Phytohemagglutinins; Precursor Cell Lymphoblastic Leukemia-Lymphoma

PY - 2007

Y1 - 2007

N2 - Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAcalpha(2-->3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders ("Controls"). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgG(MAA). Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.

AB - Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAcalpha(2-->3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders ("Controls"). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgG(MAA). Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.

U2 - 10.1016/j.leukres.2007.08.007

DO - 10.1016/j.leukres.2007.08.007

M3 - Journal article

C2 - 17889364

VL - 32

SP - 559

EP - 567

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 4

ER -

ID: 8464535