Apolipoprotein M and Risk of Type 2 Diabetes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Apolipoprotein M and Risk of Type 2 Diabetes. / Hajny, Stefan; Christoffersen, Mette; Dalila, Nawar; Nielsen, Lars B.; Tybjaerg-Hansen, Anne; Christoffersen, Christina.

In: Journal of Clinical Endocrinology & Metabolism, Vol. 105, No. 9, 2020, p. 3046-3057.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hajny, S, Christoffersen, M, Dalila, N, Nielsen, LB, Tybjaerg-Hansen, A & Christoffersen, C 2020, 'Apolipoprotein M and Risk of Type 2 Diabetes', Journal of Clinical Endocrinology & Metabolism, vol. 105, no. 9, pp. 3046-3057. https://doi.org/10.1210/clinem/dgaa433

APA

Hajny, S., Christoffersen, M., Dalila, N., Nielsen, L. B., Tybjaerg-Hansen, A., & Christoffersen, C. (2020). Apolipoprotein M and Risk of Type 2 Diabetes. Journal of Clinical Endocrinology & Metabolism, 105(9), 3046-3057. https://doi.org/10.1210/clinem/dgaa433

Vancouver

Hajny S, Christoffersen M, Dalila N, Nielsen LB, Tybjaerg-Hansen A, Christoffersen C. Apolipoprotein M and Risk of Type 2 Diabetes. Journal of Clinical Endocrinology & Metabolism. 2020;105(9):3046-3057. https://doi.org/10.1210/clinem/dgaa433

Author

Hajny, Stefan ; Christoffersen, Mette ; Dalila, Nawar ; Nielsen, Lars B. ; Tybjaerg-Hansen, Anne ; Christoffersen, Christina. / Apolipoprotein M and Risk of Type 2 Diabetes. In: Journal of Clinical Endocrinology & Metabolism. 2020 ; Vol. 105, No. 9. pp. 3046-3057.

Bibtex

@article{f39d15fdaf6648b89930a4ee2d6a574b,
title = "Apolipoprotein M and Risk of Type 2 Diabetes",
abstract = "Context: Recent studies have discovered a role of apolipoprotein M (apoM) in energy metabolism, and observational analyses in humans suggest an association with type 2 diabetes. The causal relationship remains however elusive.Objective: To investigate whether reduced plasma apoM concentrations are causally linked to increased risk of type 2 diabetes.Design: Prospective study design analyzed by Mendelian randomization.Setting and participants: Two cohorts reflecting the Danish general population: the Copenhagen City Heart Study (CCHS, n = 8589) and the Copenhagen General Population Study (CGPS; n = 93 857). Observational analyses included a subset of participants from the CCHS with available plasma apoM (n = 725). Genetic analyses included the complete cohorts (n = 102 446). During a median follow-up of 16 years (CCHS) and 8 years (CGPS), 563 and 2132 participants developed type 2 diabetes.Main outcome measures: Plasma apoM concentration, genetic variants in APOM, and type 2 diabetes.Results: First, we identified an inverse correlation between plasma apoM and risk of type 2 diabetes in a subset of participants from the CCHS (hazard ratio between highest vs lowest quartile (reference) = 0.32; 95% confidence interval = 0.1-1.01; P for trend = .02). Second, genotyping of specific single nucleotide polymorphisms in APOM further revealed a 10.8% (P = 6.2 x 10(-5)) reduced plasma apoM concentration in participants with variant rs1266078. Third, a meta-analysis including data from 599 451 individuals showed no association between rs1266078 and risk of type 2 diabetes.Conclusions: The present study does not appear to support a causal association between plasma apoM and risk of type 2 diabetes.",
keywords = "apolipoproteins, type 2 diabetes, genetics, mendelian randomization, CORONARY-HEART-DISEASE, INSULIN-RESISTANCE, ASSOCIATION, PLASMA, RECEPTOR, CHOLESTEROL, METABOLISM, LIPIDS, APOM",
author = "Stefan Hajny and Mette Christoffersen and Nawar Dalila and Nielsen, {Lars B.} and Anne Tybjaerg-Hansen and Christina Christoffersen",
year = "2020",
doi = "10.1210/clinem/dgaa433",
language = "English",
volume = "105",
pages = "3046--3057",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Apolipoprotein M and Risk of Type 2 Diabetes

AU - Hajny, Stefan

AU - Christoffersen, Mette

AU - Dalila, Nawar

AU - Nielsen, Lars B.

AU - Tybjaerg-Hansen, Anne

AU - Christoffersen, Christina

PY - 2020

Y1 - 2020

N2 - Context: Recent studies have discovered a role of apolipoprotein M (apoM) in energy metabolism, and observational analyses in humans suggest an association with type 2 diabetes. The causal relationship remains however elusive.Objective: To investigate whether reduced plasma apoM concentrations are causally linked to increased risk of type 2 diabetes.Design: Prospective study design analyzed by Mendelian randomization.Setting and participants: Two cohorts reflecting the Danish general population: the Copenhagen City Heart Study (CCHS, n = 8589) and the Copenhagen General Population Study (CGPS; n = 93 857). Observational analyses included a subset of participants from the CCHS with available plasma apoM (n = 725). Genetic analyses included the complete cohorts (n = 102 446). During a median follow-up of 16 years (CCHS) and 8 years (CGPS), 563 and 2132 participants developed type 2 diabetes.Main outcome measures: Plasma apoM concentration, genetic variants in APOM, and type 2 diabetes.Results: First, we identified an inverse correlation between plasma apoM and risk of type 2 diabetes in a subset of participants from the CCHS (hazard ratio between highest vs lowest quartile (reference) = 0.32; 95% confidence interval = 0.1-1.01; P for trend = .02). Second, genotyping of specific single nucleotide polymorphisms in APOM further revealed a 10.8% (P = 6.2 x 10(-5)) reduced plasma apoM concentration in participants with variant rs1266078. Third, a meta-analysis including data from 599 451 individuals showed no association between rs1266078 and risk of type 2 diabetes.Conclusions: The present study does not appear to support a causal association between plasma apoM and risk of type 2 diabetes.

AB - Context: Recent studies have discovered a role of apolipoprotein M (apoM) in energy metabolism, and observational analyses in humans suggest an association with type 2 diabetes. The causal relationship remains however elusive.Objective: To investigate whether reduced plasma apoM concentrations are causally linked to increased risk of type 2 diabetes.Design: Prospective study design analyzed by Mendelian randomization.Setting and participants: Two cohorts reflecting the Danish general population: the Copenhagen City Heart Study (CCHS, n = 8589) and the Copenhagen General Population Study (CGPS; n = 93 857). Observational analyses included a subset of participants from the CCHS with available plasma apoM (n = 725). Genetic analyses included the complete cohorts (n = 102 446). During a median follow-up of 16 years (CCHS) and 8 years (CGPS), 563 and 2132 participants developed type 2 diabetes.Main outcome measures: Plasma apoM concentration, genetic variants in APOM, and type 2 diabetes.Results: First, we identified an inverse correlation between plasma apoM and risk of type 2 diabetes in a subset of participants from the CCHS (hazard ratio between highest vs lowest quartile (reference) = 0.32; 95% confidence interval = 0.1-1.01; P for trend = .02). Second, genotyping of specific single nucleotide polymorphisms in APOM further revealed a 10.8% (P = 6.2 x 10(-5)) reduced plasma apoM concentration in participants with variant rs1266078. Third, a meta-analysis including data from 599 451 individuals showed no association between rs1266078 and risk of type 2 diabetes.Conclusions: The present study does not appear to support a causal association between plasma apoM and risk of type 2 diabetes.

KW - apolipoproteins

KW - type 2 diabetes

KW - genetics

KW - mendelian randomization

KW - CORONARY-HEART-DISEASE

KW - INSULIN-RESISTANCE

KW - ASSOCIATION

KW - PLASMA

KW - RECEPTOR

KW - CHOLESTEROL

KW - METABOLISM

KW - LIPIDS

KW - APOM

U2 - 10.1210/clinem/dgaa433

DO - 10.1210/clinem/dgaa433

M3 - Journal article

C2 - 32621749

VL - 105

SP - 3046

EP - 3057

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 9

ER -

ID: 251646004