Aldosterone to Renin Ratio as Screening Tool in Primary Aldosteronism
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Aldosterone to Renin Ratio as Screening Tool in Primary Aldosteronism. / Schilbach, Katharina; Junnila, Riia Karoliina; Bidlingmaier, Martin.
In: Experimental and Clinical Endocrinology and Diabetes, Vol. 127, No. 2-3, 02.2019, p. 84-92.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Aldosterone to Renin Ratio as Screening Tool in Primary Aldosteronism
AU - Schilbach, Katharina
AU - Junnila, Riia Karoliina
AU - Bidlingmaier, Martin
PY - 2019/2
Y1 - 2019/2
N2 - Primary aldosteronism (PA) is a severe and often underdiagnosed form of secondary hypertension. Determining the aldosterone to renin ratio (ARR) in hypertensive patients has been shown to be a valuable screening test for identification of patients suffering from PA. Since the introduction of a more widespread ARR screening the number of PA patients significantly increased worldwide. Interpretation of ARR might be challenging: Several factors from posture to interfering drugs affect the ARR and need to be taken into account when collecting samples. In addition, the wide variety of available assay methods and lack of well-established cut-offs present a challenge to the clinician. This review discusses the usefulness and possible difficulties of ARR screening.
AB - Primary aldosteronism (PA) is a severe and often underdiagnosed form of secondary hypertension. Determining the aldosterone to renin ratio (ARR) in hypertensive patients has been shown to be a valuable screening test for identification of patients suffering from PA. Since the introduction of a more widespread ARR screening the number of PA patients significantly increased worldwide. Interpretation of ARR might be challenging: Several factors from posture to interfering drugs affect the ARR and need to be taken into account when collecting samples. In addition, the wide variety of available assay methods and lack of well-established cut-offs present a challenge to the clinician. This review discusses the usefulness and possible difficulties of ARR screening.
KW - hypertension
KW - primary aldosteronism
KW - immunoassays
KW - interfering drugs
U2 - 10.1055/a-0672-0836
DO - 10.1055/a-0672-0836
M3 - Review
C2 - 30165708
VL - 127
SP - 84
EP - 92
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
SN - 0947-7349
IS - 2-3
ER -
ID: 229268125