Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects
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Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects. / Forbes, Josephine M; Sourris, Karly C; de Courten, Maximilian; Dougherty, Sonia L; Chand, Vibhasha; Lyons, Jasmine G; Bertovic, David; Coughlan, Melinda T; Schlaich, Markus P; Soldatos, Georgia; Cooper, Mark E; Straznicky, Nora E; Kingwell, Bronwyn A; de Courten, Barbora.
In: Journal of Amino Acids, Vol. 46, No. 2, 06.07.2013, p. 321-326.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects
AU - Forbes, Josephine M
AU - Sourris, Karly C
AU - de Courten, Maximilian
AU - Dougherty, Sonia L
AU - Chand, Vibhasha
AU - Lyons, Jasmine G
AU - Bertovic, David
AU - Coughlan, Melinda T
AU - Schlaich, Markus P
AU - Soldatos, Georgia
AU - Cooper, Mark E
AU - Straznicky, Nora E
AU - Kingwell, Bronwyn A
AU - de Courten, Barbora
PY - 2013/7/6
Y1 - 2013/7/6
N2 - It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6-31.0 kg/m(2)). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p
AB - It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ± 10 years) with a wide range of BMI (24.6-31.0 kg/m(2)). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p
U2 - 10.1007/s00726-013-1542-9
DO - 10.1007/s00726-013-1542-9
M3 - Journal article
C2 - 23832534
VL - 46
SP - 321
EP - 326
JO - Journal of Amino Acids
JF - Journal of Amino Acids
SN - 2090-0104
IS - 2
ER -
ID: 47414056