Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

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  • Dorte Strøbaek
  • Lene Teuber
  • Tino D Jørgensen
  • Philip K Ahring
  • Katrine Kjaer
  • Rie S Hansen
  • Olesen, Søren-Peter
  • Palle Christophersen
  • Bo Skaaning-Jensen
We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels have previously been reported to be activated by the benzimidazolinone, 1-EBIO and more potently by its dichloronated-analogue, DC-EBIO. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell.
Original languageEnglish
JournalBBA General Subjects
Volume1665
Issue number1-2
Pages (from-to)1-5
Number of pages4
ISSN0304-4165
DOIs
Publication statusPublished - 2004

Bibliographical note

Keywords: Benzimidazoles; Calcium Channel Agonists; Cell Line; Dose-Response Relationship, Drug; Humans; Indoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Kinetics; Oximes; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Small-Conductance Calcium-Activated Potassium Channels

ID: 8466472