Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). / Strøbaek, Dorte; Teuber, Lene; Jørgensen, Tino D; Ahring, Philip K; Kjaer, Katrine; Hansen, Rie S; Olesen, Søren Peter; Christophersen, Palle; Skaaning-Jensen, Bo.

In: BBA General Subjects, Vol. 1665, No. 1-2, 2004, p. 1-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Strøbaek, D, Teuber, L, Jørgensen, TD, Ahring, PK, Kjaer, K, Hansen, RS, Olesen, SP, Christophersen, P & Skaaning-Jensen, B 2004, 'Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).', BBA General Subjects, vol. 1665, no. 1-2, pp. 1-5. https://doi.org/10.1016/j.bbamem.2004.07.006

APA

Strøbaek, D., Teuber, L., Jørgensen, T. D., Ahring, P. K., Kjaer, K., Hansen, R. S., Olesen, S. P., Christophersen, P., & Skaaning-Jensen, B. (2004). Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). BBA General Subjects, 1665(1-2), 1-5. https://doi.org/10.1016/j.bbamem.2004.07.006

Vancouver

Strøbaek D, Teuber L, Jørgensen TD, Ahring PK, Kjaer K, Hansen RS et al. Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). BBA General Subjects. 2004;1665(1-2):1-5. https://doi.org/10.1016/j.bbamem.2004.07.006

Author

Strøbaek, Dorte ; Teuber, Lene ; Jørgensen, Tino D ; Ahring, Philip K ; Kjaer, Katrine ; Hansen, Rie S ; Olesen, Søren Peter ; Christophersen, Palle ; Skaaning-Jensen, Bo. / Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). In: BBA General Subjects. 2004 ; Vol. 1665, No. 1-2. pp. 1-5.

Bibtex

@article{17b2f360acd811ddb538000ea68e967b,
title = "Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).",
abstract = "We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels have previously been reported to be activated by the benzimidazolinone, 1-EBIO and more potently by its dichloronated-analogue, DC-EBIO. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell.",
author = "Dorte Str{\o}baek and Lene Teuber and J{\o}rgensen, {Tino D} and Ahring, {Philip K} and Katrine Kjaer and Hansen, {Rie S} and Olesen, {S{\o}ren Peter} and Palle Christophersen and Bo Skaaning-Jensen",
note = "Keywords: Benzimidazoles; Calcium Channel Agonists; Cell Line; Dose-Response Relationship, Drug; Humans; Indoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Kinetics; Oximes; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Small-Conductance Calcium-Activated Potassium Channels",
year = "2004",
doi = "10.1016/j.bbamem.2004.07.006",
language = "English",
volume = "1665",
pages = "1--5",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

AU - Strøbaek, Dorte

AU - Teuber, Lene

AU - Jørgensen, Tino D

AU - Ahring, Philip K

AU - Kjaer, Katrine

AU - Hansen, Rie S

AU - Olesen, Søren Peter

AU - Christophersen, Palle

AU - Skaaning-Jensen, Bo

N1 - Keywords: Benzimidazoles; Calcium Channel Agonists; Cell Line; Dose-Response Relationship, Drug; Humans; Indoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Kinetics; Oximes; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Small-Conductance Calcium-Activated Potassium Channels

PY - 2004

Y1 - 2004

N2 - We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels have previously been reported to be activated by the benzimidazolinone, 1-EBIO and more potently by its dichloronated-analogue, DC-EBIO. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell.

AB - We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels have previously been reported to be activated by the benzimidazolinone, 1-EBIO and more potently by its dichloronated-analogue, DC-EBIO. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell.

U2 - 10.1016/j.bbamem.2004.07.006

DO - 10.1016/j.bbamem.2004.07.006

M3 - Journal article

C2 - 15471565

VL - 1665

SP - 1

EP - 5

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 1-2

ER -

ID: 8466472