Using a classic paper by Robin Fahraeus and Torsten Lindqvist to teach basic hemorheology
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Using a classic paper by Robin Fahraeus and Torsten Lindqvist to teach basic hemorheology. / Toksvang, Linea Natalie; Berg, Ronan M G.
In: Advances in Physiology Education, Vol. 37, No. 2, 06.2013, p. 129-33.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Using a classic paper by Robin Fahraeus and Torsten Lindqvist to teach basic hemorheology
AU - Toksvang, Linea Natalie
AU - Berg, Ronan M G
PY - 2013/6
Y1 - 2013/6
N2 - "The viscosity of the blood in narrow capillary tubes" by Robin Fåhraeus and Torsten Lindqvist (Am J Physiol 96: 562-568, 1931) can be a valuable opportunity for teaching basic hemorheological principles in undergraduate cardiovascular physiology. This classic paper demonstrates that a progressive decline in apparent viscosity occurs when blood flows through glass capillary tubes of diminishing radius, which was later designated as the "Fåhraeus-Lindqvist effect." Subsequent studies have shown that apparent viscosity continues to decline at diameters that correspond to the arteriolar segments of the systemic vascular tree, where the majority of the total peripheral resistance resides and is actively regulated in vivo. The Fåhraeus-Lindqvist effect thus reduces microvascular resistance, thereby maintaining local tissue perfusion at a relatively lower blood pressure. The paper by Fåhraeus and Lindqvist can be used as a platform for a plenary discussion of these concepts as well as of the relationships among hematocrit, vessel diameter, red blood cell deformability, and resistance to blood flow and how these factors may affect the work of the heart.
AB - "The viscosity of the blood in narrow capillary tubes" by Robin Fåhraeus and Torsten Lindqvist (Am J Physiol 96: 562-568, 1931) can be a valuable opportunity for teaching basic hemorheological principles in undergraduate cardiovascular physiology. This classic paper demonstrates that a progressive decline in apparent viscosity occurs when blood flows through glass capillary tubes of diminishing radius, which was later designated as the "Fåhraeus-Lindqvist effect." Subsequent studies have shown that apparent viscosity continues to decline at diameters that correspond to the arteriolar segments of the systemic vascular tree, where the majority of the total peripheral resistance resides and is actively regulated in vivo. The Fåhraeus-Lindqvist effect thus reduces microvascular resistance, thereby maintaining local tissue perfusion at a relatively lower blood pressure. The paper by Fåhraeus and Lindqvist can be used as a platform for a plenary discussion of these concepts as well as of the relationships among hematocrit, vessel diameter, red blood cell deformability, and resistance to blood flow and how these factors may affect the work of the heart.
KW - Arterial Pressure
KW - Arterioles/physiology
KW - Blood Viscosity
KW - Curriculum
KW - Erythrocyte Deformability
KW - Erythrocytes/physiology
KW - Hemorheology
KW - Humans
KW - Microcirculation
KW - Models, Biological
KW - Physiology/education
KW - Regional Blood Flow
KW - Teaching/methods
KW - Vascular Resistance
U2 - 10.1152/advan.00009.2013
DO - 10.1152/advan.00009.2013
M3 - Journal article
C2 - 23728130
VL - 37
SP - 129
EP - 133
JO - American Journal of Physiology - Advances in Physiology Education
JF - American Journal of Physiology - Advances in Physiology Education
SN - 1043-4046
IS - 2
ER -
ID: 236993448