Usefulness of layer-specific strain in diagnosis of coronary artery disease in patients with stable angina pectoris
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Usefulness of layer-specific strain in diagnosis of coronary artery disease in patients with stable angina pectoris. / Hagemann, Christoffer A.; Hoffmann, Soren; Hagemann, Rikke A.; Fritz-Hansen, Thomas; Olsen, Flemming J.; Jorgensen, Peter G.; Biering-Sorensen, Tor.
In: International Journal of Cardiovascular Imaging, Vol. 35, No. 11, 2019, p. 1989-1999.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Usefulness of layer-specific strain in diagnosis of coronary artery disease in patients with stable angina pectoris
AU - Hagemann, Christoffer A.
AU - Hoffmann, Soren
AU - Hagemann, Rikke A.
AU - Fritz-Hansen, Thomas
AU - Olsen, Flemming J.
AU - Jorgensen, Peter G.
AU - Biering-Sorensen, Tor
PY - 2019
Y1 - 2019
N2 - Novel software allows for layer-specific evaluation of myocardial strain by speckle tracking echocardiography (2DSTE). However, the potential of layer-specific strain at rest for diagnosing coronary artery disease (CAD) in patients with suspected stable angina pectoris (SAP) remains unknown. Our objective was to evaluate the usefulness of layer-specific 2DSTE at rest for diagnosis of CAD in patients with SAP. In total, 285 patients referred with clinically suspected SAP, normal ejection fraction, and no previous cardiac history were prospectively enrolled. All patients were examined by echocardiography, including 2DSTE, exercise ECG, and coronary angiography (CAG). Layer-specific 2DSTE was performed in three apical views to provide longitudinal peak systolic strains. Stenosis >= 70% in >= 1 major coronary artery on CAG was considered as significant CAD. Of 285 patients included, 104 had significant CAD (36%). Endocardial, epicardial, and mid-myocardial GLS were all significantly impaired in CAD patients (P < 0.001). Multivariable analysis including baseline clinical parameters, conventional echocardiographic measurements, Duke score, and layer-specific strain measurements revealed epicardial [odds ratio 1.19 (P = 0.048)] and mid-myocardial [odds ratio 1.16 (P = 0.047)] global longitudinal strain (GLS) as the only independent predictors of CAD. In direct comparison, epicardial and mid-myocardial GLS had a significantly higher diagnostic performance compared to endocardial GLS (P = 0.038 and P = 0.031, respectively). In conclusion, layer-specific GLS from 2DSTE at rest was significantly impaired in patients with significant CAD. In addition, epicardial and mid-myocardial GLS were independent predictors of CAD.
AB - Novel software allows for layer-specific evaluation of myocardial strain by speckle tracking echocardiography (2DSTE). However, the potential of layer-specific strain at rest for diagnosing coronary artery disease (CAD) in patients with suspected stable angina pectoris (SAP) remains unknown. Our objective was to evaluate the usefulness of layer-specific 2DSTE at rest for diagnosis of CAD in patients with SAP. In total, 285 patients referred with clinically suspected SAP, normal ejection fraction, and no previous cardiac history were prospectively enrolled. All patients were examined by echocardiography, including 2DSTE, exercise ECG, and coronary angiography (CAG). Layer-specific 2DSTE was performed in three apical views to provide longitudinal peak systolic strains. Stenosis >= 70% in >= 1 major coronary artery on CAG was considered as significant CAD. Of 285 patients included, 104 had significant CAD (36%). Endocardial, epicardial, and mid-myocardial GLS were all significantly impaired in CAD patients (P < 0.001). Multivariable analysis including baseline clinical parameters, conventional echocardiographic measurements, Duke score, and layer-specific strain measurements revealed epicardial [odds ratio 1.19 (P = 0.048)] and mid-myocardial [odds ratio 1.16 (P = 0.047)] global longitudinal strain (GLS) as the only independent predictors of CAD. In direct comparison, epicardial and mid-myocardial GLS had a significantly higher diagnostic performance compared to endocardial GLS (P = 0.038 and P = 0.031, respectively). In conclusion, layer-specific GLS from 2DSTE at rest was significantly impaired in patients with significant CAD. In addition, epicardial and mid-myocardial GLS were independent predictors of CAD.
KW - Angina
KW - Coronary artery disease
KW - Echocardiography
KW - Speckle tracking
U2 - 10.1007/s10554-019-01652-3
DO - 10.1007/s10554-019-01652-3
M3 - Journal article
C2 - 31227953
VL - 35
SP - 1989
EP - 1999
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
SN - 1569-5794
IS - 11
ER -
ID: 229897487