The role of mitochondrial dysfunction in the progression of Alzheimer’s disease
Research output: Contribution to journal › Review › Research › peer-review
Standard
The role of mitochondrial dysfunction in the progression of Alzheimer’s disease. / Desler, Claus; Lillenes, Meryl S.; Tønjum, Tone; Rasmussen, Lene Juel.
In: Current Medicinal Chemistry, Vol. 25, No. 40, 2018, p. 5578 - 5587.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The role of mitochondrial dysfunction in the progression of Alzheimer’s disease
AU - Desler, Claus
AU - Lillenes, Meryl S.
AU - Tønjum, Tone
AU - Rasmussen, Lene Juel
PY - 2018
Y1 - 2018
N2 - The current molecular understanding of Alzheimer’s disease (AD) has still not resulted in successful interventions. Mitochondrial dysfunction of the AD brain is currently emerging as a hallmark of this disease. One mitochondrial function often affected in AD is oxidative phosphorylation responsible for ATP production, but also for production of reactive oxygen species (ROS) and for the de novo synthesis of pyrimidines. This paper reviews the role of mitochondrial produced ROS and pyrimidines in the aetiology of AD and their proposed role in oxidative degeneration of macromolecules, synthesis of essential phospholipids and maintenance of mitochondrial viability in the AD brain.
AB - The current molecular understanding of Alzheimer’s disease (AD) has still not resulted in successful interventions. Mitochondrial dysfunction of the AD brain is currently emerging as a hallmark of this disease. One mitochondrial function often affected in AD is oxidative phosphorylation responsible for ATP production, but also for production of reactive oxygen species (ROS) and for the de novo synthesis of pyrimidines. This paper reviews the role of mitochondrial produced ROS and pyrimidines in the aetiology of AD and their proposed role in oxidative degeneration of macromolecules, synthesis of essential phospholipids and maintenance of mitochondrial viability in the AD brain.
U2 - 10.2174/0929867324666170616110111
DO - 10.2174/0929867324666170616110111
M3 - Review
C2 - 28618998
VL - 25
SP - 5578
EP - 5587
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 40
ER -
ID: 189863451