The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes

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The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes. / Fredheim, Siri; Andersen, Marie-Louise M; Pörksen, Sven; Nielsen, Lotte B; Pipper, Christian; Hansen, Lars; Holst, Jens Juul; Thomsen, Jane; Johannesen, Jesper; Mortensen, Henrik B; Svensson, Jannet.

In: Diabetologia, Vol. 58, No. 4, 2015, p. 828-34.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Fredheim, S, Andersen, M-LM, Pörksen, S, Nielsen, LB, Pipper, C, Hansen, L, Holst, JJ, Thomsen, J, Johannesen, J, Mortensen, HB & Svensson, J 2015, 'The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes', Diabetologia, vol. 58, no. 4, pp. 828-34. https://doi.org/10.1007/s00125-014-3486-3

APA

Fredheim, S., Andersen, M-L. M., Pörksen, S., Nielsen, L. B., Pipper, C., Hansen, L., Holst, J. J., Thomsen, J., Johannesen, J., Mortensen, H. B., & Svensson, J. (2015). The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes. Diabetologia, 58(4), 828-34. https://doi.org/10.1007/s00125-014-3486-3

Vancouver

Fredheim S, Andersen M-LM, Pörksen S, Nielsen LB, Pipper C, Hansen L et al. The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes. Diabetologia. 2015;58(4):828-34. https://doi.org/10.1007/s00125-014-3486-3

Author

Fredheim, Siri ; Andersen, Marie-Louise M ; Pörksen, Sven ; Nielsen, Lotte B ; Pipper, Christian ; Hansen, Lars ; Holst, Jens Juul ; Thomsen, Jane ; Johannesen, Jesper ; Mortensen, Henrik B ; Svensson, Jannet. / The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes. In: Diabetologia. 2015 ; Vol. 58, No. 4. pp. 828-34.

Bibtex

@article{f77802b66c96407bba0f89d54f0b57fa,
title = "The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes",
abstract = "AIMS/HYPOTHESIS: The influence of glucagon on glycaemic control in type 1 diabetes is debated. We investigated the relationship between postprandial glucagon levels and HbA1c during a period up to 60 months after diagnosis of childhood type 1 diabetes.METHODS: The Danish remission phase cohort comprised 129 children (66 boys) with type 1 diabetes whose mean (SD) age at onset was 10.0 (3.9) years. Liquid mixed-meal tests were performed prospectively at 1, 3, 6 and 12 months and a subset of 40 patients completed follow-up at 60 months. Postprandial (90 min) plasma levels of glucagon, glucose (PG), C-peptide, total glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and HbA1c were analysed. Multivariate regression (repeated measurements with all five visits included) was applied and results expressed as relative change (95% CI).RESULTS: Postprandial glucagon levels increased 160% from 1 to 60 months after diagnosis (p < 0.0001). A doubling in postprandial PG corresponded to a 21% increase in postprandial glucagon levels (p = 0.0079), whereas a doubling in total GLP-1 levels corresponded to a 33% increase in glucagon levels (p < 0.0001). Postprandial glucagon associated negatively with postprandial C-peptide (p = 0.017). A doubling in postprandial glucagon corresponded to a 3% relative increase in HbA1c levels (p = 0.0045).CONCLUSIONS/INTERPRETATION: Postprandial glucagon levels were associated with deterioration of glycaemic control and declining beta cell function in the first 5 years after diagnosis of type 1 diabetes. The positive association of glucagon with total GLP-1 and PG suggests that physiological regulation of alpha cell secretion in type 1 diabetes is seriously disturbed.",
author = "Siri Fredheim and Andersen, {Marie-Louise M} and Sven P{\"o}rksen and Nielsen, {Lotte B} and Christian Pipper and Lars Hansen and Holst, {Jens Juul} and Jane Thomsen and Jesper Johannesen and Mortensen, {Henrik B} and Jannet Svensson",
year = "2015",
doi = "10.1007/s00125-014-3486-3",
language = "English",
volume = "58",
pages = "828--34",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes

AU - Fredheim, Siri

AU - Andersen, Marie-Louise M

AU - Pörksen, Sven

AU - Nielsen, Lotte B

AU - Pipper, Christian

AU - Hansen, Lars

AU - Holst, Jens Juul

AU - Thomsen, Jane

AU - Johannesen, Jesper

AU - Mortensen, Henrik B

AU - Svensson, Jannet

PY - 2015

Y1 - 2015

N2 - AIMS/HYPOTHESIS: The influence of glucagon on glycaemic control in type 1 diabetes is debated. We investigated the relationship between postprandial glucagon levels and HbA1c during a period up to 60 months after diagnosis of childhood type 1 diabetes.METHODS: The Danish remission phase cohort comprised 129 children (66 boys) with type 1 diabetes whose mean (SD) age at onset was 10.0 (3.9) years. Liquid mixed-meal tests were performed prospectively at 1, 3, 6 and 12 months and a subset of 40 patients completed follow-up at 60 months. Postprandial (90 min) plasma levels of glucagon, glucose (PG), C-peptide, total glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and HbA1c were analysed. Multivariate regression (repeated measurements with all five visits included) was applied and results expressed as relative change (95% CI).RESULTS: Postprandial glucagon levels increased 160% from 1 to 60 months after diagnosis (p < 0.0001). A doubling in postprandial PG corresponded to a 21% increase in postprandial glucagon levels (p = 0.0079), whereas a doubling in total GLP-1 levels corresponded to a 33% increase in glucagon levels (p < 0.0001). Postprandial glucagon associated negatively with postprandial C-peptide (p = 0.017). A doubling in postprandial glucagon corresponded to a 3% relative increase in HbA1c levels (p = 0.0045).CONCLUSIONS/INTERPRETATION: Postprandial glucagon levels were associated with deterioration of glycaemic control and declining beta cell function in the first 5 years after diagnosis of type 1 diabetes. The positive association of glucagon with total GLP-1 and PG suggests that physiological regulation of alpha cell secretion in type 1 diabetes is seriously disturbed.

AB - AIMS/HYPOTHESIS: The influence of glucagon on glycaemic control in type 1 diabetes is debated. We investigated the relationship between postprandial glucagon levels and HbA1c during a period up to 60 months after diagnosis of childhood type 1 diabetes.METHODS: The Danish remission phase cohort comprised 129 children (66 boys) with type 1 diabetes whose mean (SD) age at onset was 10.0 (3.9) years. Liquid mixed-meal tests were performed prospectively at 1, 3, 6 and 12 months and a subset of 40 patients completed follow-up at 60 months. Postprandial (90 min) plasma levels of glucagon, glucose (PG), C-peptide, total glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and HbA1c were analysed. Multivariate regression (repeated measurements with all five visits included) was applied and results expressed as relative change (95% CI).RESULTS: Postprandial glucagon levels increased 160% from 1 to 60 months after diagnosis (p < 0.0001). A doubling in postprandial PG corresponded to a 21% increase in postprandial glucagon levels (p = 0.0079), whereas a doubling in total GLP-1 levels corresponded to a 33% increase in glucagon levels (p < 0.0001). Postprandial glucagon associated negatively with postprandial C-peptide (p = 0.017). A doubling in postprandial glucagon corresponded to a 3% relative increase in HbA1c levels (p = 0.0045).CONCLUSIONS/INTERPRETATION: Postprandial glucagon levels were associated with deterioration of glycaemic control and declining beta cell function in the first 5 years after diagnosis of type 1 diabetes. The positive association of glucagon with total GLP-1 and PG suggests that physiological regulation of alpha cell secretion in type 1 diabetes is seriously disturbed.

U2 - 10.1007/s00125-014-3486-3

DO - 10.1007/s00125-014-3486-3

M3 - Journal article

C2 - 25541633

VL - 58

SP - 828

EP - 834

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 4

ER -

ID: 132046764