The impact of the COVID-19 lockdown on birthweight among singleton term birth in Denmark
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The impact of the COVID-19 lockdown on birthweight among singleton term birth in Denmark. / Knegt, Victoria E de; Hedley, Paula L; Hedermann, Gitte; Wilstrup, Casper; Bækvad-Hansen, Marie; Thagaard, Ida N; Hjalgrim, Henrik; Kanters, JK; Melbye, Mads; Hougaard, David M; Hviid, Anders; Krebs, Lone; Breindahl, Morten; Lausten-Thomsen, Ulrik; Christiansen, Michael.
In: PLoS ONE, Vol. 18, No. 4, e0283909., 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - The impact of the COVID-19 lockdown on birthweight among singleton term birth in Denmark
AU - Knegt, Victoria E de
AU - Hedley, Paula L
AU - Hedermann, Gitte
AU - Wilstrup, Casper
AU - Bækvad-Hansen, Marie
AU - Thagaard, Ida N
AU - Hjalgrim, Henrik
AU - Kanters, JK
AU - Melbye, Mads
AU - Hougaard, David M
AU - Hviid, Anders
AU - Krebs, Lone
AU - Breindahl, Morten
AU - Lausten-Thomsen, Ulrik
AU - Christiansen, Michael
PY - 2023
Y1 - 2023
N2 - In Denmark, a nationwide COVID-19 lockdown was implemented on March 12, 2020 and eased on April 14, 2020. The COVID-19 lockdown featured reduced prevalence of extremely preterm or extremely low birthweight births. This study aims to explore the impact of this COVID-19 lockdown on term birthweights in Denmark. We conducted a nationwide register-based cohort study on 27,870 live singleton infants, born at term (weeks 37-41), between March 12 and April 14, 2015-2020, using data from the Danish Neonatal Screening Biobank. Primary outcomes, corrected for confounders, were birthweight, small-for-gestational-age (SGA), and large-for-gestational-age (LGA), comparing the COVID-19 lockdown to the previous five years. Data were analysed using linear regression to assess associations with birthweight. Multinomial logistic regression was used to assess associations with relative-size-for-gestational-age (xGA) categories. Adjusted mean birthweight was significantly increased by 16.9 g (95% CI = 4.1-31.3) during the lockdown period. A dip in mean birthweight was found in gestational weeks 37 and 38 balanced by an increase in weeks 40 and 41. The 2020 lockdown period was associated with an increased LGA prevalence (aOR 1.13, 95% CI = 1.05-1.21). No significant changes in proportions of xGA groups were found between 2015 and 2019. The nationwide COVID-19 lockdown resulted in a small but significant increase in birthweight and proportion of LGA infants, driven by an increase in birthweight in gestational weeks 40 and 41.
AB - In Denmark, a nationwide COVID-19 lockdown was implemented on March 12, 2020 and eased on April 14, 2020. The COVID-19 lockdown featured reduced prevalence of extremely preterm or extremely low birthweight births. This study aims to explore the impact of this COVID-19 lockdown on term birthweights in Denmark. We conducted a nationwide register-based cohort study on 27,870 live singleton infants, born at term (weeks 37-41), between March 12 and April 14, 2015-2020, using data from the Danish Neonatal Screening Biobank. Primary outcomes, corrected for confounders, were birthweight, small-for-gestational-age (SGA), and large-for-gestational-age (LGA), comparing the COVID-19 lockdown to the previous five years. Data were analysed using linear regression to assess associations with birthweight. Multinomial logistic regression was used to assess associations with relative-size-for-gestational-age (xGA) categories. Adjusted mean birthweight was significantly increased by 16.9 g (95% CI = 4.1-31.3) during the lockdown period. A dip in mean birthweight was found in gestational weeks 37 and 38 balanced by an increase in weeks 40 and 41. The 2020 lockdown period was associated with an increased LGA prevalence (aOR 1.13, 95% CI = 1.05-1.21). No significant changes in proportions of xGA groups were found between 2015 and 2019. The nationwide COVID-19 lockdown resulted in a small but significant increase in birthweight and proportion of LGA infants, driven by an increase in birthweight in gestational weeks 40 and 41.
U2 - 10.1371/journal.pone.0283909
DO - 10.1371/journal.pone.0283909
M3 - Journal article
C2 - 37079534
VL - 18
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 4
M1 - e0283909.
ER -
ID: 345179268