Super Resolution Ultrasound Imaging using the Erythrocytes: I: Density Images
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Super Resolution Ultrasound Imaging using the Erythrocytes : I: Density Images. / Jensen, Jorgen Arendt; Naji, Mostafa Amin; Praesius, Sebastian Kazmarek; Taghavi, Iman; Schou, Mikkel; Hansen, Lauge Naur; Andersen, Sofie Bech; Sogaard, Stinne Byrholdt; Panduro, Nathalie Sarup; Sorensen, Charlotte Mehlin; Nielsen, Michael Bachmann; Gundlach, Carsten; Kjer, Hans Martin; Dahl, Anders Bjorholm; Tomov, Borislav Gueorguiev; Ommen, Martin Lind; Larsen, Niels Bent; Thomsen, Erik Vilain.
In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Super Resolution Ultrasound Imaging using the Erythrocytes
T2 - I: Density Images
AU - Jensen, Jorgen Arendt
AU - Naji, Mostafa Amin
AU - Praesius, Sebastian Kazmarek
AU - Taghavi, Iman
AU - Schou, Mikkel
AU - Hansen, Lauge Naur
AU - Andersen, Sofie Bech
AU - Sogaard, Stinne Byrholdt
AU - Panduro, Nathalie Sarup
AU - Sorensen, Charlotte Mehlin
AU - Nielsen, Michael Bachmann
AU - Gundlach, Carsten
AU - Kjer, Hans Martin
AU - Dahl, Anders Bjorholm
AU - Tomov, Borislav Gueorguiev
AU - Ommen, Martin Lind
AU - Larsen, Niels Bent
AU - Thomsen, Erik Vilain
N1 - Publisher Copyright: Authors
PY - 2024
Y1 - 2024
N2 - A new approach for vascular super resolution imaging using the erythrocytes as targets (SURE imaging) is described and investigated. SURE imaging does not require fragile contrast agent bubbles, making it possible to use the maximum allowable mechanical index for ultrasound scanning for an increased penetration depth. A synthetic aperture ultrasound sequence was employed with 12 virtual sources using a 10 MHz GE L8-18i-D linear array hockey stick probe. The axial resolution was 1.20λ,(185.0μm) and the lateral resolution was 1.50λ,(231.3μm). Field IIpro simulations were conducted on 12.5 μm radius vessel pairs with varying separations. A vessel pair with a separation of 70 μm could be resolved, indicating a SURE image resolution below half a wavelength. A Verasonics research scanner was used for the in vivo experiments to scan the kidneys of Sprague-Dawley rats for up to 46 s to visualize their microvasculature by processing from 0.1 up to 45 s of data for SURE imaging, and for 46.8 s for super resolution (SR) imaging with a SonoVue contrast agent. Afterward, the renal vasculature was filled with the ex vivo micro-CT contrast agent Microfil, excised, and scanned in a micro-CT scanner at both a 22.6 μm voxel size for 11 hours, and for 20 hours in a 5 μm voxel size for validating the SURE images. Comparing the SURE and micro-CT images revealed that vessels with a diameter of 28 μm, five times smaller than the ultrasound wavelength, could be detected, and the dense grid of microvessels in the full kidney was shown for scan times between 1 to 10 s. The vessel structure in the cortex was also similar for the SURE and SR images. Fourier ring correlation indicated a resolution capability of 29 μm. SURE images are acquired in seconds rather than minutes without any patient preparation or contrast injection, making the method translatable to clinical use.
AB - A new approach for vascular super resolution imaging using the erythrocytes as targets (SURE imaging) is described and investigated. SURE imaging does not require fragile contrast agent bubbles, making it possible to use the maximum allowable mechanical index for ultrasound scanning for an increased penetration depth. A synthetic aperture ultrasound sequence was employed with 12 virtual sources using a 10 MHz GE L8-18i-D linear array hockey stick probe. The axial resolution was 1.20λ,(185.0μm) and the lateral resolution was 1.50λ,(231.3μm). Field IIpro simulations were conducted on 12.5 μm radius vessel pairs with varying separations. A vessel pair with a separation of 70 μm could be resolved, indicating a SURE image resolution below half a wavelength. A Verasonics research scanner was used for the in vivo experiments to scan the kidneys of Sprague-Dawley rats for up to 46 s to visualize their microvasculature by processing from 0.1 up to 45 s of data for SURE imaging, and for 46.8 s for super resolution (SR) imaging with a SonoVue contrast agent. Afterward, the renal vasculature was filled with the ex vivo micro-CT contrast agent Microfil, excised, and scanned in a micro-CT scanner at both a 22.6 μm voxel size for 11 hours, and for 20 hours in a 5 μm voxel size for validating the SURE images. Comparing the SURE and micro-CT images revealed that vessels with a diameter of 28 μm, five times smaller than the ultrasound wavelength, could be detected, and the dense grid of microvessels in the full kidney was shown for scan times between 1 to 10 s. The vessel structure in the cortex was also similar for the SURE and SR images. Fourier ring correlation indicated a resolution capability of 29 μm. SURE images are acquired in seconds rather than minutes without any patient preparation or contrast injection, making the method translatable to clinical use.
KW - Acoustics
KW - Apertures
KW - erythrocytes
KW - fast imaging
KW - Imaging
KW - micro-CT
KW - microvascular imaging
KW - Pipelines
KW - Probes
KW - Super-resolution ultrasound imaging
KW - Superresolution
KW - synthetic aperture
KW - Ultrasonic imaging
KW - ultrasound localization microscopy
U2 - 10.1109/TUFFC.2024.3411711
DO - 10.1109/TUFFC.2024.3411711
M3 - Journal article
C2 - 38857145
AN - SCOPUS:85196105208
JO - I E E E Transactions on Ultrasonics, Ferroelectrics and Frequency Control
JF - I E E E Transactions on Ultrasonics, Ferroelectrics and Frequency Control
SN - 0885-3010
ER -
ID: 396859974