Sex differences in echocardiographic predictors of bradycardia detected by implantable loop recorder in patients with syncope and palpitations

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Sex differences in echocardiographic predictors of bradycardia detected by implantable loop recorder in patients with syncope and palpitations. / Falsing, Mathilde Musoni; Brainin, Philip; Andersen, Ditte Madsen; Larroudé, Charlotte Ellen; Lindhardt, Tommi Bo; Ravnkilde, Kirstine; Modin, Daniel; Karsum, Emil Høegholm; Gislason, Gunnar; Biering-Sørensen, Tor.

In: Echocardiography, Vol. 38, No. 7, 2021, p. 1186-1194.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Falsing, MM, Brainin, P, Andersen, DM, Larroudé, CE, Lindhardt, TB, Ravnkilde, K, Modin, D, Karsum, EH, Gislason, G & Biering-Sørensen, T 2021, 'Sex differences in echocardiographic predictors of bradycardia detected by implantable loop recorder in patients with syncope and palpitations', Echocardiography, vol. 38, no. 7, pp. 1186-1194. https://doi.org/10.1111/echo.15085

APA

Falsing, M. M., Brainin, P., Andersen, D. M., Larroudé, C. E., Lindhardt, T. B., Ravnkilde, K., Modin, D., Karsum, E. H., Gislason, G., & Biering-Sørensen, T. (2021). Sex differences in echocardiographic predictors of bradycardia detected by implantable loop recorder in patients with syncope and palpitations. Echocardiography, 38(7), 1186-1194. https://doi.org/10.1111/echo.15085

Vancouver

Falsing MM, Brainin P, Andersen DM, Larroudé CE, Lindhardt TB, Ravnkilde K et al. Sex differences in echocardiographic predictors of bradycardia detected by implantable loop recorder in patients with syncope and palpitations. Echocardiography. 2021;38(7):1186-1194. https://doi.org/10.1111/echo.15085

Author

Falsing, Mathilde Musoni ; Brainin, Philip ; Andersen, Ditte Madsen ; Larroudé, Charlotte Ellen ; Lindhardt, Tommi Bo ; Ravnkilde, Kirstine ; Modin, Daniel ; Karsum, Emil Høegholm ; Gislason, Gunnar ; Biering-Sørensen, Tor. / Sex differences in echocardiographic predictors of bradycardia detected by implantable loop recorder in patients with syncope and palpitations. In: Echocardiography. 2021 ; Vol. 38, No. 7. pp. 1186-1194.

Bibtex

@article{01392836219f479398e6d63f365a1058,
title = "Sex differences in echocardiographic predictors of bradycardia detected by implantable loop recorder in patients with syncope and palpitations",
abstract = "Objective: Our aim was to investigate whether echocardiography may aid in identifying patients, specifically men, at risk of bradycardia as detected by implantable loop recorders (ILR) in patients evaluated for syncope and palpitations. Methods: We included ambulatory patients undergoing ILR implantation for syncope (84%), presyncope (9%), and palpitations (8%). Echocardiographic examination was performed prior to implantation (2.9 months [IQR 1.0–6.0 months]). Echocardiograms were analyzed for conventional and speckle tracking parameters. We examined time to first event of bradycardia, defined as (a) heart rate <30 beats/min and (b) ≥4 beats, including sinus arrest, asystole, sinoatrial block, and second- and third-degree atrioventricular nodal block. We applied Cox proportional hazards models. Results: A total of 285 patients we enrolled, and during a median time of 2.7 years [IQR 1.0, 3.3 years] of continuous heart rhythm monitoring, 84 (29%) had bradycardia detected by ILR. Patients with bradycardia were older (61 ± 19 years vs 55 ± 18 years, P =.01) and more frequently men (62% vs 44%, P =.01). Sex modified the association between echocardiographic parameters and bradycardia (P interaction <0.05 for all), such that left ventricular LV mass index (HR: 1.02 per 1g/m2 increase [1.01-1.04], P <.001), LV ejection fraction (HR: 1.04 per 1% decrease [1.01-1.08], P =.02), and global longitudinal strain (HR: 1.09 per 1% decrease [1.01-1.19], P =.03) were associated with bradycardia in men but not women (P >.05 for all in female). After adjusting for baseline clinical characteristics, medical therapy, and loop indication, the abovementioned parameters remained significantly associated with incident bradycardia in men. Conclusion: Echocardiographic parameters of LV structure and function may potentially be more useful for predicting bradycardia in men than women, among patients undergoing ILR implantation for syncope, presyncope, and palpations.",
author = "Falsing, {Mathilde Musoni} and Philip Brainin and Andersen, {Ditte Madsen} and Larroud{\'e}, {Charlotte Ellen} and Lindhardt, {Tommi Bo} and Kirstine Ravnkilde and Daniel Modin and Karsum, {Emil H{\o}egholm} and Gunnar Gislason and Tor Biering-S{\o}rensen",
note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",
year = "2021",
doi = "10.1111/echo.15085",
language = "English",
volume = "38",
pages = "1186--1194",
journal = "Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques",
issn = "0742-2822",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Sex differences in echocardiographic predictors of bradycardia detected by implantable loop recorder in patients with syncope and palpitations

AU - Falsing, Mathilde Musoni

AU - Brainin, Philip

AU - Andersen, Ditte Madsen

AU - Larroudé, Charlotte Ellen

AU - Lindhardt, Tommi Bo

AU - Ravnkilde, Kirstine

AU - Modin, Daniel

AU - Karsum, Emil Høegholm

AU - Gislason, Gunnar

AU - Biering-Sørensen, Tor

N1 - Publisher Copyright: © 2021 Wiley Periodicals LLC.

PY - 2021

Y1 - 2021

N2 - Objective: Our aim was to investigate whether echocardiography may aid in identifying patients, specifically men, at risk of bradycardia as detected by implantable loop recorders (ILR) in patients evaluated for syncope and palpitations. Methods: We included ambulatory patients undergoing ILR implantation for syncope (84%), presyncope (9%), and palpitations (8%). Echocardiographic examination was performed prior to implantation (2.9 months [IQR 1.0–6.0 months]). Echocardiograms were analyzed for conventional and speckle tracking parameters. We examined time to first event of bradycardia, defined as (a) heart rate <30 beats/min and (b) ≥4 beats, including sinus arrest, asystole, sinoatrial block, and second- and third-degree atrioventricular nodal block. We applied Cox proportional hazards models. Results: A total of 285 patients we enrolled, and during a median time of 2.7 years [IQR 1.0, 3.3 years] of continuous heart rhythm monitoring, 84 (29%) had bradycardia detected by ILR. Patients with bradycardia were older (61 ± 19 years vs 55 ± 18 years, P =.01) and more frequently men (62% vs 44%, P =.01). Sex modified the association between echocardiographic parameters and bradycardia (P interaction <0.05 for all), such that left ventricular LV mass index (HR: 1.02 per 1g/m2 increase [1.01-1.04], P <.001), LV ejection fraction (HR: 1.04 per 1% decrease [1.01-1.08], P =.02), and global longitudinal strain (HR: 1.09 per 1% decrease [1.01-1.19], P =.03) were associated with bradycardia in men but not women (P >.05 for all in female). After adjusting for baseline clinical characteristics, medical therapy, and loop indication, the abovementioned parameters remained significantly associated with incident bradycardia in men. Conclusion: Echocardiographic parameters of LV structure and function may potentially be more useful for predicting bradycardia in men than women, among patients undergoing ILR implantation for syncope, presyncope, and palpations.

AB - Objective: Our aim was to investigate whether echocardiography may aid in identifying patients, specifically men, at risk of bradycardia as detected by implantable loop recorders (ILR) in patients evaluated for syncope and palpitations. Methods: We included ambulatory patients undergoing ILR implantation for syncope (84%), presyncope (9%), and palpitations (8%). Echocardiographic examination was performed prior to implantation (2.9 months [IQR 1.0–6.0 months]). Echocardiograms were analyzed for conventional and speckle tracking parameters. We examined time to first event of bradycardia, defined as (a) heart rate <30 beats/min and (b) ≥4 beats, including sinus arrest, asystole, sinoatrial block, and second- and third-degree atrioventricular nodal block. We applied Cox proportional hazards models. Results: A total of 285 patients we enrolled, and during a median time of 2.7 years [IQR 1.0, 3.3 years] of continuous heart rhythm monitoring, 84 (29%) had bradycardia detected by ILR. Patients with bradycardia were older (61 ± 19 years vs 55 ± 18 years, P =.01) and more frequently men (62% vs 44%, P =.01). Sex modified the association between echocardiographic parameters and bradycardia (P interaction <0.05 for all), such that left ventricular LV mass index (HR: 1.02 per 1g/m2 increase [1.01-1.04], P <.001), LV ejection fraction (HR: 1.04 per 1% decrease [1.01-1.08], P =.02), and global longitudinal strain (HR: 1.09 per 1% decrease [1.01-1.19], P =.03) were associated with bradycardia in men but not women (P >.05 for all in female). After adjusting for baseline clinical characteristics, medical therapy, and loop indication, the abovementioned parameters remained significantly associated with incident bradycardia in men. Conclusion: Echocardiographic parameters of LV structure and function may potentially be more useful for predicting bradycardia in men than women, among patients undergoing ILR implantation for syncope, presyncope, and palpations.

U2 - 10.1111/echo.15085

DO - 10.1111/echo.15085

M3 - Journal article

C2 - 34037991

AN - SCOPUS:85106413418

VL - 38

SP - 1186

EP - 1194

JO - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques

JF - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques

SN - 0742-2822

IS - 7

ER -

ID: 301448823