Sex- and age-related differences in the predictive capability of circulating biomarkers: from the MONICA 10 cohort
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Sex- and age-related differences in the predictive capability of circulating biomarkers : from the MONICA 10 cohort. / Frary, Charles E.; Biering-Sørensen, Tor; Nochioka, Kotaro; Blicher, Marie K.; Olesen, Thomas B.; Stidsen, Jacob V.; Greve, Sara V.; Vishram-Nielsen, Julie K.K.; Rasmussen, Susanne L.; Eugen-Olsen, Jesper; Olsen, Michael H.; Pareek, Manan.
In: Scandinavian Cardiovascular Journal, Vol. 55, No. 2, 2021, p. 65-72.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sex- and age-related differences in the predictive capability of circulating biomarkers
T2 - from the MONICA 10 cohort
AU - Frary, Charles E.
AU - Biering-Sørensen, Tor
AU - Nochioka, Kotaro
AU - Blicher, Marie K.
AU - Olesen, Thomas B.
AU - Stidsen, Jacob V.
AU - Greve, Sara V.
AU - Vishram-Nielsen, Julie K.K.
AU - Rasmussen, Susanne L.
AU - Eugen-Olsen, Jesper
AU - Olsen, Michael H.
AU - Pareek, Manan
N1 - Publisher Copyright: © 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Objectives: The purpose of this study was to assess whether high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-brain natriuretic peptide (NT-proBNP), and soluble urokinase plasminogen activator receptor (suPAR) differed in their ability to predict cardiovascular outcomes beyond traditional risk factors in younger and older men and women without known cardiovascular disease. Design. Prospective population-based cohort study of 1951 individuals from the MONItoring of trends and determinants in Cardiovascular disease (MONICA) study, examined 1993–1994. Participants were stratified into four groups based on sex and age. Subjects aged 41 or 51 years were classified as younger; those aged 61 or 71 years were classified as older. The principal endpoint was death from cardiovascular causes. Predictive capabilities of biomarkers were tested using Cox proportional-hazards regression, Harrell’s concordance-index, net reclassification improvement, and classification and regression tree (CART) analysis. Results. Median follow-up was 18.5 years, during which 19/597 younger men, 100/380 older men, 12/607 younger women, and 46/367 older women had died from a cardiovascular cause. NT-proBNP was independently associated with death from cardiovascular causes among all participants (p ≤.02) except younger women (p =.70), whereas hs-CRP was associated with this endpoint in men (p ≤.007), and suPAR in older men only (p <.001). None of the biomarkers improved discrimination ability beyond traditional risk factors (p ≥.07). However, NT-proBNP enhanced reclassification in men and older women. CART-analysis showed that NT-proBNP was generally of greater value among men, and suPAR among women. Conclusions. Hs-CRP, NT-proBNP, and suPAR displayed different associations with cardiovascular death among apparently healthy younger and older men and women.
AB - Objectives: The purpose of this study was to assess whether high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-brain natriuretic peptide (NT-proBNP), and soluble urokinase plasminogen activator receptor (suPAR) differed in their ability to predict cardiovascular outcomes beyond traditional risk factors in younger and older men and women without known cardiovascular disease. Design. Prospective population-based cohort study of 1951 individuals from the MONItoring of trends and determinants in Cardiovascular disease (MONICA) study, examined 1993–1994. Participants were stratified into four groups based on sex and age. Subjects aged 41 or 51 years were classified as younger; those aged 61 or 71 years were classified as older. The principal endpoint was death from cardiovascular causes. Predictive capabilities of biomarkers were tested using Cox proportional-hazards regression, Harrell’s concordance-index, net reclassification improvement, and classification and regression tree (CART) analysis. Results. Median follow-up was 18.5 years, during which 19/597 younger men, 100/380 older men, 12/607 younger women, and 46/367 older women had died from a cardiovascular cause. NT-proBNP was independently associated with death from cardiovascular causes among all participants (p ≤.02) except younger women (p =.70), whereas hs-CRP was associated with this endpoint in men (p ≤.007), and suPAR in older men only (p <.001). None of the biomarkers improved discrimination ability beyond traditional risk factors (p ≥.07). However, NT-proBNP enhanced reclassification in men and older women. CART-analysis showed that NT-proBNP was generally of greater value among men, and suPAR among women. Conclusions. Hs-CRP, NT-proBNP, and suPAR displayed different associations with cardiovascular death among apparently healthy younger and older men and women.
KW - Assessment
KW - biomarkers
KW - brain
KW - C-reactive protein
KW - cardiovascular diseases
KW - natriuretic peptide
KW - receptor
KW - risk
KW - urokinase plasminogen activator
UR - http://www.scopus.com/inward/record.url?scp=85096943599&partnerID=8YFLogxK
U2 - 10.1080/14017431.2020.1853217
DO - 10.1080/14017431.2020.1853217
M3 - Journal article
C2 - 33251867
AN - SCOPUS:85096943599
VL - 55
SP - 65
EP - 72
JO - Scandinavian Cardiovascular Journal
JF - Scandinavian Cardiovascular Journal
SN - 1401-7458
IS - 2
ER -
ID: 317935212