Serotonin receptors involved in vasopressin and oxytocin secretion

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Standard

Serotonin receptors involved in vasopressin and oxytocin secretion. / Jørgensen, Henrik; Riis, M.; Knigge, U.; Kjær, A.; Warberg, J.

In: Journal of Neuroendocrinology, Vol. 15, No. 3, 01.03.2003, p. 242-249.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Jørgensen, H, Riis, M, Knigge, U, Kjær, A & Warberg, J 2003, 'Serotonin receptors involved in vasopressin and oxytocin secretion', Journal of Neuroendocrinology, vol. 15, no. 3, pp. 242-249. https://doi.org/10.1046/j.1365-2826.2003.00978.x

APA

Jørgensen, H., Riis, M., Knigge, U., Kjær, A., & Warberg, J. (2003). Serotonin receptors involved in vasopressin and oxytocin secretion. Journal of Neuroendocrinology, 15(3), 242-249. https://doi.org/10.1046/j.1365-2826.2003.00978.x

Vancouver

Jørgensen H, Riis M, Knigge U, Kjær A, Warberg J. Serotonin receptors involved in vasopressin and oxytocin secretion. Journal of Neuroendocrinology. 2003 Mar 1;15(3):242-249. https://doi.org/10.1046/j.1365-2826.2003.00978.x

Author

Jørgensen, Henrik ; Riis, M. ; Knigge, U. ; Kjær, A. ; Warberg, J. / Serotonin receptors involved in vasopressin and oxytocin secretion. In: Journal of Neuroendocrinology. 2003 ; Vol. 15, No. 3. pp. 242-249.

Bibtex

@article{0ddc1ddf9d104063aa03934b687dc2f0,
title = "Serotonin receptors involved in vasopressin and oxytocin secretion",
abstract = "Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin. We investigated the involvement of 5-HT receptors in the serotonergic regulation of vasopressin and oxytocin secretion. Vasopressin and oxytocin secretion was stimulated by 5-HT, the 5-HT1A+1B+5A+7 agonist 5-carboxamidotryptamine (5-CT), the 5-HT2A+2C agonist DOI, the 5-HT2C+2A agonist mCPP, the 5-HT2C agonist MK-212, the 5-HT3 agonist SR 57277 and the 5-HT4 agonist RS 67506. The 5-HT1A agonist 8-OH-DPAT, which had no effect on vasopressin secretion, stimulated oxytocin secretion. The 5-HT-induced release of vasopressin and oxytocin was inhibited by central infusion of the 5-HT antagonists WAY 100635 (5-HT1A), LY 53857 (5-HT2A+2C), ICS 205-930 (5-HT3+4) and RS 23597 (5-HT4). The 5-HT2+6+7 antagonist metergoline in combination with the 5-HT1A+2+7 antagonist methysergide inhibited the stimulatory effect of 5-CT on both hormones, whereas the 5-HT1A+1B antagonist cyanopindolol only inhibited the oxytocin response. The 5-HT2A antagonist 4-(4-flourobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate had no effect on DOI-induced hormone response. The 5-HT2C antagonist Y 25130 partly inhibited the stimulating effect of MK-212. ICS 205-930 and RS 23597 inhibited vasopressin and oxytocin secretion induced by RS 67506. WAY 100635 inhibited 8-OH-DPAT-induced oxytocin secretion. We conclude that 5-HT-induced vasopressin secretion primarily is mediated via 5-HT2C, 5-HT4 and 5-HT7 receptors, whereas 5-HT2A, 5-HT3 and 5-HT5A receptors seem to be of minor importance. 5-HT-induced oxytocin secretion involves 5-HT1A, 5-HT2C and 5-HT4 receptors; in addition an involvement of 5-HT1B, 5-HT5A and 5-HT7 receptors seems likely, whereas 5-HT2A and 5-HT3 receptors seem to be less important.",
keywords = "5-HT-receptor, 5-HT, 5-HT receptor, Neuroendocrine regulation, Oxytocin, Serotonin, Vasopressin",
author = "Henrik J{\o}rgensen and M. Riis and U. Knigge and A. Kj{\ae}r and J. Warberg",
year = "2003",
month = mar,
day = "1",
doi = "10.1046/j.1365-2826.2003.00978.x",
language = "English",
volume = "15",
pages = "242--249",
journal = "Journal of Neuroendocrinology",
issn = "0953-8194",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Serotonin receptors involved in vasopressin and oxytocin secretion

AU - Jørgensen, Henrik

AU - Riis, M.

AU - Knigge, U.

AU - Kjær, A.

AU - Warberg, J.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin. We investigated the involvement of 5-HT receptors in the serotonergic regulation of vasopressin and oxytocin secretion. Vasopressin and oxytocin secretion was stimulated by 5-HT, the 5-HT1A+1B+5A+7 agonist 5-carboxamidotryptamine (5-CT), the 5-HT2A+2C agonist DOI, the 5-HT2C+2A agonist mCPP, the 5-HT2C agonist MK-212, the 5-HT3 agonist SR 57277 and the 5-HT4 agonist RS 67506. The 5-HT1A agonist 8-OH-DPAT, which had no effect on vasopressin secretion, stimulated oxytocin secretion. The 5-HT-induced release of vasopressin and oxytocin was inhibited by central infusion of the 5-HT antagonists WAY 100635 (5-HT1A), LY 53857 (5-HT2A+2C), ICS 205-930 (5-HT3+4) and RS 23597 (5-HT4). The 5-HT2+6+7 antagonist metergoline in combination with the 5-HT1A+2+7 antagonist methysergide inhibited the stimulatory effect of 5-CT on both hormones, whereas the 5-HT1A+1B antagonist cyanopindolol only inhibited the oxytocin response. The 5-HT2A antagonist 4-(4-flourobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate had no effect on DOI-induced hormone response. The 5-HT2C antagonist Y 25130 partly inhibited the stimulating effect of MK-212. ICS 205-930 and RS 23597 inhibited vasopressin and oxytocin secretion induced by RS 67506. WAY 100635 inhibited 8-OH-DPAT-induced oxytocin secretion. We conclude that 5-HT-induced vasopressin secretion primarily is mediated via 5-HT2C, 5-HT4 and 5-HT7 receptors, whereas 5-HT2A, 5-HT3 and 5-HT5A receptors seem to be of minor importance. 5-HT-induced oxytocin secretion involves 5-HT1A, 5-HT2C and 5-HT4 receptors; in addition an involvement of 5-HT1B, 5-HT5A and 5-HT7 receptors seems likely, whereas 5-HT2A and 5-HT3 receptors seem to be less important.

AB - Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin. We investigated the involvement of 5-HT receptors in the serotonergic regulation of vasopressin and oxytocin secretion. Vasopressin and oxytocin secretion was stimulated by 5-HT, the 5-HT1A+1B+5A+7 agonist 5-carboxamidotryptamine (5-CT), the 5-HT2A+2C agonist DOI, the 5-HT2C+2A agonist mCPP, the 5-HT2C agonist MK-212, the 5-HT3 agonist SR 57277 and the 5-HT4 agonist RS 67506. The 5-HT1A agonist 8-OH-DPAT, which had no effect on vasopressin secretion, stimulated oxytocin secretion. The 5-HT-induced release of vasopressin and oxytocin was inhibited by central infusion of the 5-HT antagonists WAY 100635 (5-HT1A), LY 53857 (5-HT2A+2C), ICS 205-930 (5-HT3+4) and RS 23597 (5-HT4). The 5-HT2+6+7 antagonist metergoline in combination with the 5-HT1A+2+7 antagonist methysergide inhibited the stimulatory effect of 5-CT on both hormones, whereas the 5-HT1A+1B antagonist cyanopindolol only inhibited the oxytocin response. The 5-HT2A antagonist 4-(4-flourobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate had no effect on DOI-induced hormone response. The 5-HT2C antagonist Y 25130 partly inhibited the stimulating effect of MK-212. ICS 205-930 and RS 23597 inhibited vasopressin and oxytocin secretion induced by RS 67506. WAY 100635 inhibited 8-OH-DPAT-induced oxytocin secretion. We conclude that 5-HT-induced vasopressin secretion primarily is mediated via 5-HT2C, 5-HT4 and 5-HT7 receptors, whereas 5-HT2A, 5-HT3 and 5-HT5A receptors seem to be of minor importance. 5-HT-induced oxytocin secretion involves 5-HT1A, 5-HT2C and 5-HT4 receptors; in addition an involvement of 5-HT1B, 5-HT5A and 5-HT7 receptors seems likely, whereas 5-HT2A and 5-HT3 receptors seem to be less important.

KW - 5-HT-receptor

KW - 5-HT

KW - 5-HT receptor

KW - Neuroendocrine regulation

KW - Oxytocin

KW - Serotonin

KW - Vasopressin

UR - http://www.scopus.com/inward/record.url?scp=0037373005&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2826.2003.00978.x

DO - 10.1046/j.1365-2826.2003.00978.x

M3 - Review

C2 - 12588512

AN - SCOPUS:0037373005

VL - 15

SP - 242

EP - 249

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

IS - 3

ER -

ID: 283515050