Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release. / Kofod, Hans; Holst, J J; Lernmark, A.

In: Regulatory Peptides, Vol. 23, No. 3, 12.1988, p. 315-22.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kofod, H, Holst, JJ & Lernmark, A 1988, 'Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release', Regulatory Peptides, vol. 23, no. 3, pp. 315-22.

APA

Kofod, H., Holst, J. J., & Lernmark, A. (1988). Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release. Regulatory Peptides, 23(3), 315-22.

Vancouver

Kofod H, Holst JJ, Lernmark A. Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release. Regulatory Peptides. 1988 Dec;23(3):315-22.

Author

Kofod, Hans ; Holst, J J ; Lernmark, A. / Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release. In: Regulatory Peptides. 1988 ; Vol. 23, No. 3. pp. 315-22.

Bibtex

@article{6e03986bd5c743deafa3ec065b182b12,
title = "Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release",
abstract = "The effect of secretin on glucagon and insulin release and its interaction with glucose has been studied in cultured mouse pancreatic islets by column perifusion. Glucose alone showed the well-known stimulation of insulin release and inhibition of glucagon release. Addition of 10 mM secretin increased glucagon secretion at 3 mM D-glucose by 300% while no change in insulin release could be seen at this low glucose concentration. At maximal stimulation of insulin release by 20 mM D-glucose addition of 10 nM secretin increased insulin release by 30%. Despite this insulin concentration and the high glucose concentration an increase in glucagon secretion of 1800% was found. These effects of secretin were dose-dependent at 10 mM D-glucose with 1 nM secretin being the lowest effective dose.",
keywords = "Animals, Cells, Cultured, Dose-Response Relationship, Drug, Glucagon, Glucose, Insulin, Islets of Langerhans, Male, Mice, Secretin",
author = "Hans Kofod and Holst, {J J} and A Lernmark",
year = "1988",
month = dec,
language = "English",
volume = "23",
pages = "315--22",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release

AU - Kofod, Hans

AU - Holst, J J

AU - Lernmark, A

PY - 1988/12

Y1 - 1988/12

N2 - The effect of secretin on glucagon and insulin release and its interaction with glucose has been studied in cultured mouse pancreatic islets by column perifusion. Glucose alone showed the well-known stimulation of insulin release and inhibition of glucagon release. Addition of 10 mM secretin increased glucagon secretion at 3 mM D-glucose by 300% while no change in insulin release could be seen at this low glucose concentration. At maximal stimulation of insulin release by 20 mM D-glucose addition of 10 nM secretin increased insulin release by 30%. Despite this insulin concentration and the high glucose concentration an increase in glucagon secretion of 1800% was found. These effects of secretin were dose-dependent at 10 mM D-glucose with 1 nM secretin being the lowest effective dose.

AB - The effect of secretin on glucagon and insulin release and its interaction with glucose has been studied in cultured mouse pancreatic islets by column perifusion. Glucose alone showed the well-known stimulation of insulin release and inhibition of glucagon release. Addition of 10 mM secretin increased glucagon secretion at 3 mM D-glucose by 300% while no change in insulin release could be seen at this low glucose concentration. At maximal stimulation of insulin release by 20 mM D-glucose addition of 10 nM secretin increased insulin release by 30%. Despite this insulin concentration and the high glucose concentration an increase in glucagon secretion of 1800% was found. These effects of secretin were dose-dependent at 10 mM D-glucose with 1 nM secretin being the lowest effective dose.

KW - Animals

KW - Cells, Cultured

KW - Dose-Response Relationship, Drug

KW - Glucagon

KW - Glucose

KW - Insulin

KW - Islets of Langerhans

KW - Male

KW - Mice

KW - Secretin

M3 - Journal article

C2 - 3070646

VL - 23

SP - 315

EP - 322

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 3

ER -

ID: 45575058