Role of peripheral vascular resistance for the association between major depression and cardiovascular disease
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Role of peripheral vascular resistance for the association between major depression and cardiovascular disease. / Bouzinova, Elena V.; Wiborg, Ove; Aalkjaer, Christian; Matchkov, Vladimir V.
In: Journal of Cardiovascular Pharmacology, Vol. 65, No. 4, 04.2015, p. 299-307.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Role of peripheral vascular resistance for the association between major depression and cardiovascular disease
AU - Bouzinova, Elena V.
AU - Wiborg, Ove
AU - Aalkjaer, Christian
AU - Matchkov, Vladimir V.
PY - 2015/4
Y1 - 2015/4
N2 - Major depression and cardiovascular diseases are 2 of the most prevalent health problems in Western society, and an association between them is generally accepted. Although the specific mechanism behind this comorbidity remains to be elucidated, it is clear that it has a complex multifactorial character including a number of neuronal, humoral, immune, and circulatory pathways. Depression-associated cardiovascular abnormalities associate with cardiac dysfunctions and with changes in peripheral resistance. Although cardiac dysfunction in association with depression has been studied in detail, little attention was given to structural and functional changes in resistance arteries responsible for blood pressure control and tissue perfusion. This review discusses recent achievements in studies of depression-associated abnormalities in resistance arteries in humans and animal experimental models. The changes in arterial structure, contractile and relaxing functions associated with depression symptoms are discussed, and the role of these abnormalities for the pathology of major depression and cardiovascular diseases are suggested.
AB - Major depression and cardiovascular diseases are 2 of the most prevalent health problems in Western society, and an association between them is generally accepted. Although the specific mechanism behind this comorbidity remains to be elucidated, it is clear that it has a complex multifactorial character including a number of neuronal, humoral, immune, and circulatory pathways. Depression-associated cardiovascular abnormalities associate with cardiac dysfunctions and with changes in peripheral resistance. Although cardiac dysfunction in association with depression has been studied in detail, little attention was given to structural and functional changes in resistance arteries responsible for blood pressure control and tissue perfusion. This review discusses recent achievements in studies of depression-associated abnormalities in resistance arteries in humans and animal experimental models. The changes in arterial structure, contractile and relaxing functions associated with depression symptoms are discussed, and the role of these abnormalities for the pathology of major depression and cardiovascular diseases are suggested.
KW - Animals
KW - Blood Vessels
KW - Cardiovascular Diseases
KW - Comorbidity
KW - Depressive Disorder, Major
KW - Humans
KW - Vascular Resistance
U2 - 10.1097/FJC.0000000000000187
DO - 10.1097/FJC.0000000000000187
M3 - Journal article
C2 - 25469807
VL - 65
SP - 299
EP - 307
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 4
ER -
ID: 154482583