Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis: The SEAS study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis : The SEAS study. / Greve, Anders M; Bang, Casper N; Berg, Ronan M G; Egstrup, Kenneth; Rossebø, Anne B; Boman, Kurt; Nienaber, Christoph A; Ray, Simon; Gohlke-Baerwolf, Christa; Nielsen, Olav W; Okin, Peter M; Devereux, Richard B; Køber, Lars; Wachtell, Kristian.

In: International Journal of Cardiology, Vol. 180, 02.2015, p. 122-128.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Greve, AM, Bang, CN, Berg, RMG, Egstrup, K, Rossebø, AB, Boman, K, Nienaber, CA, Ray, S, Gohlke-Baerwolf, C, Nielsen, OW, Okin, PM, Devereux, RB, Køber, L & Wachtell, K 2015, 'Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis: The SEAS study', International Journal of Cardiology, vol. 180, pp. 122-128. https://doi.org/10.1016/j.ijcard.2014.11.181

APA

Greve, A. M., Bang, C. N., Berg, R. M. G., Egstrup, K., Rossebø, A. B., Boman, K., Nienaber, C. A., Ray, S., Gohlke-Baerwolf, C., Nielsen, O. W., Okin, P. M., Devereux, R. B., Køber, L., & Wachtell, K. (2015). Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis: The SEAS study. International Journal of Cardiology, 180, 122-128. https://doi.org/10.1016/j.ijcard.2014.11.181

Vancouver

Greve AM, Bang CN, Berg RMG, Egstrup K, Rossebø AB, Boman K et al. Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis: The SEAS study. International Journal of Cardiology. 2015 Feb;180:122-128. https://doi.org/10.1016/j.ijcard.2014.11.181

Author

Greve, Anders M ; Bang, Casper N ; Berg, Ronan M G ; Egstrup, Kenneth ; Rossebø, Anne B ; Boman, Kurt ; Nienaber, Christoph A ; Ray, Simon ; Gohlke-Baerwolf, Christa ; Nielsen, Olav W ; Okin, Peter M ; Devereux, Richard B ; Køber, Lars ; Wachtell, Kristian. / Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis : The SEAS study. In: International Journal of Cardiology. 2015 ; Vol. 180. pp. 122-128.

Bibtex

@article{b6b0af302e08488aa686d16de65013cb,
title = "Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis: The SEAS study",
abstract = "BACKGROUND: An elevated resting heart rate (RHR) may be an early sign of cardiac failure, but its prognostic value during watchful waiting in asymptomatic aortic stenosis (AS) is largely unknown.METHODS: RHR was determined by annual ECGs in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study of asymptomatic mild-to-moderate AS patients. Primary endpoint in this substudy was major cardiovascular events (MCEs) and secondary outcomes its individual components. Multivariable Cox-models using serially-measured RHR were used to examine the prognostic impact of RHR per se.RESULTS: 1563 patients were followed for a mean of 4.3years (6751 patient-years of follow-up), 553 (35%) MCEs occurred, 10% (n=151) died, including 75 cardiovascular deaths. In multivariable analysis, baseline RHR was independently associated with MCEs (HR 1.1 per 10min(-1) faster, 95% CI: 1.0-1.3) and cardiovascular mortality (HR 1.3 per 10min(-1) faster, 95% CI: 1.0-1.7, both p≤0.03). Updating RHR with annual in-study reexaminations, time-varying RHR was highly associated with excess MCEs (HR 1.1 per 10min(-1) faster, 95% CI: 1.1-1.3) and cardiovascular mortality (HR 1.4 per 10min(-1) faster, 95% CI: 1.2-1.7, both p≤0.006). The association of RHR with MCEs and cardiovascular mortality was not dependent on atrial fibrillation status (both p≥0.06 for interaction).CONCLUSIONS: RHR is independently associated with MCEs and cardiovascular death in asymptomatic AS (Clinicaltrials.gov; unique identifier NCT00092677).",
keywords = "Aged, Anticholesteremic Agents, Aortic Valve Stenosis, Atrial Fibrillation, Azetidines, Double-Blind Method, Drug Therapy, Combination, Ezetimibe, Female, Follow-Up Studies, Global Health, Heart Failure, Heart Rate, Humans, Male, Middle Aged, Prognosis, Proportional Hazards Models, Prospective Studies, Rest, Simvastatin, Survival Rate, Time Factors",
author = "Greve, {Anders M} and Bang, {Casper N} and Berg, {Ronan M G} and Kenneth Egstrup and Rosseb{\o}, {Anne B} and Kurt Boman and Nienaber, {Christoph A} and Simon Ray and Christa Gohlke-Baerwolf and Nielsen, {Olav W} and Okin, {Peter M} and Devereux, {Richard B} and Lars K{\o}ber and Kristian Wachtell",
note = "Copyright {\textcopyright} 2014 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
month = feb,
doi = "10.1016/j.ijcard.2014.11.181",
language = "English",
volume = "180",
pages = "122--128",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis

T2 - The SEAS study

AU - Greve, Anders M

AU - Bang, Casper N

AU - Berg, Ronan M G

AU - Egstrup, Kenneth

AU - Rossebø, Anne B

AU - Boman, Kurt

AU - Nienaber, Christoph A

AU - Ray, Simon

AU - Gohlke-Baerwolf, Christa

AU - Nielsen, Olav W

AU - Okin, Peter M

AU - Devereux, Richard B

AU - Køber, Lars

AU - Wachtell, Kristian

N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND: An elevated resting heart rate (RHR) may be an early sign of cardiac failure, but its prognostic value during watchful waiting in asymptomatic aortic stenosis (AS) is largely unknown.METHODS: RHR was determined by annual ECGs in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study of asymptomatic mild-to-moderate AS patients. Primary endpoint in this substudy was major cardiovascular events (MCEs) and secondary outcomes its individual components. Multivariable Cox-models using serially-measured RHR were used to examine the prognostic impact of RHR per se.RESULTS: 1563 patients were followed for a mean of 4.3years (6751 patient-years of follow-up), 553 (35%) MCEs occurred, 10% (n=151) died, including 75 cardiovascular deaths. In multivariable analysis, baseline RHR was independently associated with MCEs (HR 1.1 per 10min(-1) faster, 95% CI: 1.0-1.3) and cardiovascular mortality (HR 1.3 per 10min(-1) faster, 95% CI: 1.0-1.7, both p≤0.03). Updating RHR with annual in-study reexaminations, time-varying RHR was highly associated with excess MCEs (HR 1.1 per 10min(-1) faster, 95% CI: 1.1-1.3) and cardiovascular mortality (HR 1.4 per 10min(-1) faster, 95% CI: 1.2-1.7, both p≤0.006). The association of RHR with MCEs and cardiovascular mortality was not dependent on atrial fibrillation status (both p≥0.06 for interaction).CONCLUSIONS: RHR is independently associated with MCEs and cardiovascular death in asymptomatic AS (Clinicaltrials.gov; unique identifier NCT00092677).

AB - BACKGROUND: An elevated resting heart rate (RHR) may be an early sign of cardiac failure, but its prognostic value during watchful waiting in asymptomatic aortic stenosis (AS) is largely unknown.METHODS: RHR was determined by annual ECGs in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study of asymptomatic mild-to-moderate AS patients. Primary endpoint in this substudy was major cardiovascular events (MCEs) and secondary outcomes its individual components. Multivariable Cox-models using serially-measured RHR were used to examine the prognostic impact of RHR per se.RESULTS: 1563 patients were followed for a mean of 4.3years (6751 patient-years of follow-up), 553 (35%) MCEs occurred, 10% (n=151) died, including 75 cardiovascular deaths. In multivariable analysis, baseline RHR was independently associated with MCEs (HR 1.1 per 10min(-1) faster, 95% CI: 1.0-1.3) and cardiovascular mortality (HR 1.3 per 10min(-1) faster, 95% CI: 1.0-1.7, both p≤0.03). Updating RHR with annual in-study reexaminations, time-varying RHR was highly associated with excess MCEs (HR 1.1 per 10min(-1) faster, 95% CI: 1.1-1.3) and cardiovascular mortality (HR 1.4 per 10min(-1) faster, 95% CI: 1.2-1.7, both p≤0.006). The association of RHR with MCEs and cardiovascular mortality was not dependent on atrial fibrillation status (both p≥0.06 for interaction).CONCLUSIONS: RHR is independently associated with MCEs and cardiovascular death in asymptomatic AS (Clinicaltrials.gov; unique identifier NCT00092677).

KW - Aged

KW - Anticholesteremic Agents

KW - Aortic Valve Stenosis

KW - Atrial Fibrillation

KW - Azetidines

KW - Double-Blind Method

KW - Drug Therapy, Combination

KW - Ezetimibe

KW - Female

KW - Follow-Up Studies

KW - Global Health

KW - Heart Failure

KW - Heart Rate

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Rest

KW - Simvastatin

KW - Survival Rate

KW - Time Factors

U2 - 10.1016/j.ijcard.2014.11.181

DO - 10.1016/j.ijcard.2014.11.181

M3 - Journal article

C2 - 25438232

VL - 180

SP - 122

EP - 128

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -

ID: 156458860