Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans

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Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. / Nauck, Michael A; Kemmeries, Guido; Holst, Jens Juul; Meier, Juris J.

In: Diabetes, Vol. 60, No. 5, 2011, p. 1561-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nauck, MA, Kemmeries, G, Holst, JJ & Meier, JJ 2011, 'Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans', Diabetes, vol. 60, no. 5, pp. 1561-5. https://doi.org/10.2337/db10-0474

APA

Nauck, M. A., Kemmeries, G., Holst, J. J., & Meier, J. J. (2011). Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes, 60(5), 1561-5. https://doi.org/10.2337/db10-0474

Vancouver

Nauck MA, Kemmeries G, Holst JJ, Meier JJ. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes. 2011;60(5):1561-5. https://doi.org/10.2337/db10-0474

Author

Nauck, Michael A ; Kemmeries, Guido ; Holst, Jens Juul ; Meier, Juris J. / Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. In: Diabetes. 2011 ; Vol. 60, No. 5. pp. 1561-5.

Bibtex

@article{1cfd3d713aae4dd9bace071446033dbb,
title = "Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans",
abstract = "OBJECTIVE: Glucagon-like peptide (GLP)-1 lowers postprandial glycemia primarily through inhibition of gastric emptying. We addressed whether the GLP-1-induced deceleration of gastric emptying is subject to rapid tachyphylaxis and if so, how this would alter postprandial glucose control.RESEARCH DESIGN AND METHODS: Nine healthy volunteers (25 ± 4 years old, BMI: 24.6 ± 4.7 kg/m(2)) were examined with intravenous infusion of GLP-1 (0.8 pmol · kg(-1) · min(-1)) or placebo over 8.5 h. Two liquid mixed meals were administered at a 4-h interval. Gastric emptying was determined, and blood samples were drawn frequently.RESULTS: GLP-1 decelerated gastric emptying significantly more after the first meal compared with the second meal (P = 0.01). This was associated with reductions in pancreatic polypeptide levels (marker of vagal activation) after the first but not the second meal (P < 0.05). With GLP-1, glucose concentrations declined after the first meal but increased after the second meal (P < 0.05). The GLP-1-induced reductions in postprandial insulin and C-peptide levels were stronger during the first meal course (P < 0.05). Likewise, glucagon levels were lowered by GLP-1 after the first meal but increased after the second test meal (P < 0.05).CONCLUSIONS: The GLP-1-induced delay in gastric emptying is subject to rapid tachyphylaxis at the level of vagal nervous activation. As a consequence, postprandial glucose control by GLP-1 is attenuated after its chronic administration",
keywords = "Adult, Blood Glucose, C-Peptide, Gastric Emptying, Glucagon, Glucagon-Like Peptide 1, Humans, Male, Postprandial Period, Tachyphylaxis, Young Adult",
author = "Nauck, {Michael A} and Guido Kemmeries and Holst, {Jens Juul} and Meier, {Juris J}",
year = "2011",
doi = "10.2337/db10-0474",
language = "English",
volume = "60",
pages = "1561--5",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "5",

}

RIS

TY - JOUR

T1 - Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans

AU - Nauck, Michael A

AU - Kemmeries, Guido

AU - Holst, Jens Juul

AU - Meier, Juris J

PY - 2011

Y1 - 2011

N2 - OBJECTIVE: Glucagon-like peptide (GLP)-1 lowers postprandial glycemia primarily through inhibition of gastric emptying. We addressed whether the GLP-1-induced deceleration of gastric emptying is subject to rapid tachyphylaxis and if so, how this would alter postprandial glucose control.RESEARCH DESIGN AND METHODS: Nine healthy volunteers (25 ± 4 years old, BMI: 24.6 ± 4.7 kg/m(2)) were examined with intravenous infusion of GLP-1 (0.8 pmol · kg(-1) · min(-1)) or placebo over 8.5 h. Two liquid mixed meals were administered at a 4-h interval. Gastric emptying was determined, and blood samples were drawn frequently.RESULTS: GLP-1 decelerated gastric emptying significantly more after the first meal compared with the second meal (P = 0.01). This was associated with reductions in pancreatic polypeptide levels (marker of vagal activation) after the first but not the second meal (P < 0.05). With GLP-1, glucose concentrations declined after the first meal but increased after the second meal (P < 0.05). The GLP-1-induced reductions in postprandial insulin and C-peptide levels were stronger during the first meal course (P < 0.05). Likewise, glucagon levels were lowered by GLP-1 after the first meal but increased after the second test meal (P < 0.05).CONCLUSIONS: The GLP-1-induced delay in gastric emptying is subject to rapid tachyphylaxis at the level of vagal nervous activation. As a consequence, postprandial glucose control by GLP-1 is attenuated after its chronic administration

AB - OBJECTIVE: Glucagon-like peptide (GLP)-1 lowers postprandial glycemia primarily through inhibition of gastric emptying. We addressed whether the GLP-1-induced deceleration of gastric emptying is subject to rapid tachyphylaxis and if so, how this would alter postprandial glucose control.RESEARCH DESIGN AND METHODS: Nine healthy volunteers (25 ± 4 years old, BMI: 24.6 ± 4.7 kg/m(2)) were examined with intravenous infusion of GLP-1 (0.8 pmol · kg(-1) · min(-1)) or placebo over 8.5 h. Two liquid mixed meals were administered at a 4-h interval. Gastric emptying was determined, and blood samples were drawn frequently.RESULTS: GLP-1 decelerated gastric emptying significantly more after the first meal compared with the second meal (P = 0.01). This was associated with reductions in pancreatic polypeptide levels (marker of vagal activation) after the first but not the second meal (P < 0.05). With GLP-1, glucose concentrations declined after the first meal but increased after the second meal (P < 0.05). The GLP-1-induced reductions in postprandial insulin and C-peptide levels were stronger during the first meal course (P < 0.05). Likewise, glucagon levels were lowered by GLP-1 after the first meal but increased after the second test meal (P < 0.05).CONCLUSIONS: The GLP-1-induced delay in gastric emptying is subject to rapid tachyphylaxis at the level of vagal nervous activation. As a consequence, postprandial glucose control by GLP-1 is attenuated after its chronic administration

KW - Adult

KW - Blood Glucose

KW - C-Peptide

KW - Gastric Emptying

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Humans

KW - Male

KW - Postprandial Period

KW - Tachyphylaxis

KW - Young Adult

U2 - 10.2337/db10-0474

DO - 10.2337/db10-0474

M3 - Journal article

C2 - 21430088

VL - 60

SP - 1561

EP - 1565

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 5

ER -

ID: 40321041