Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men. / Ribel-Madsen, Amalie; Ribel-Madsen, Rasmus; Brøns, Charlotte; Newgard, Christopher B; Vaag, Allan; Hellgren, Lars I.

In: Physiological Reports, Vol. 4, No. 19, e12977, 29.09.2016.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ribel-Madsen, A, Ribel-Madsen, R, Brøns, C, Newgard, CB, Vaag, A & Hellgren, LI 2016, 'Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men', Physiological Reports, vol. 4, no. 19, e12977. https://doi.org/10.14814/phy2.12977

APA

Ribel-Madsen, A., Ribel-Madsen, R., Brøns, C., Newgard, C. B., Vaag, A., & Hellgren, L. I. (2016). Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men. Physiological Reports, 4(19), [e12977]. https://doi.org/10.14814/phy2.12977

Vancouver

Ribel-Madsen A, Ribel-Madsen R, Brøns C, Newgard CB, Vaag A, Hellgren LI. Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men. Physiological Reports. 2016 Sep 29;4(19). e12977. https://doi.org/10.14814/phy2.12977

Author

Ribel-Madsen, Amalie ; Ribel-Madsen, Rasmus ; Brøns, Charlotte ; Newgard, Christopher B ; Vaag, Allan ; Hellgren, Lars I. / Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men. In: Physiological Reports. 2016 ; Vol. 4, No. 19.

Bibtex

@article{9ff08eb13378497eb67159d012a7ca07,

title = "Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men",

abstract = "We hypothesized that an increased, incomplete fatty acid beta-oxidation in mitochondria could be part of the metabolic events leading to insulin resistance and thereby an increased type 2 diabetes risk in low birth weight (LBW) compared with normal birth weight (NBW) individuals. Therefore, we measured fasting plasma levels of 45 acylcarnitine species in 18 LBW and 25 NBW men after an isocaloric control diet and a 5-day high-fat, high-calorie diet. We demonstrated that LBW men had higher C2 and C4-OH levels after the control diet compared with NBW men, indicating an increased fatty acid beta-oxidation relative to the tricarboxylic acid cycle flux. Also, they had higher C6-DC, C10-OH/C8-DC, and total hydroxyl-/dicarboxyl-acylcarnitine levels, which may suggest an increased fatty acid omega-oxidation in the liver. Furthermore, LBW and NBW men decreased several acylcarnitine levels in response to overfeeding, which is likely a result of an upregulation of fatty acid oxidation due to the dietary challenge. Moreover, C10-OH/C8-DC and total hydroxyl-/dicarboxyl-acylcarnitine levels tended to be negatively associated with the serum insulin level, and the total hydroxyl-/dicarboxyl-acylcarnitine level additionally tended to be negatively associated with the hepatic insulin resistance index. This indicates that an increased fatty acid omega-oxidation could be a compensatory mechanism to prevent an accumulation of lipid species that impair insulin signaling.",

keywords = "Journal Article",

author = "Amalie Ribel-Madsen and Rasmus Ribel-Madsen and Charlotte Br{\o}ns and Newgard, {Christopher B} and Allan Vaag and Hellgren, {Lars I}",

note = "{\textcopyright} 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.",

year = "2016",

month = sep,

day = "29",

doi = "10.14814/phy2.12977",

language = "English",

volume = "4",

journal = "Physiological Reports",

issn = "2051-817X",

publisher = "Wiley Periodicals, Inc.",

number = "19",

}

RIS

TY - JOUR

T1 - Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men

AU - Ribel-Madsen, Amalie

AU - Ribel-Madsen, Rasmus

AU - Brøns, Charlotte

AU - Newgard, Christopher B

AU - Vaag, Allan

AU - Hellgren, Lars I

PY - 2016/9/29

Y1 - 2016/9/29

N2 - We hypothesized that an increased, incomplete fatty acid beta-oxidation in mitochondria could be part of the metabolic events leading to insulin resistance and thereby an increased type 2 diabetes risk in low birth weight (LBW) compared with normal birth weight (NBW) individuals. Therefore, we measured fasting plasma levels of 45 acylcarnitine species in 18 LBW and 25 NBW men after an isocaloric control diet and a 5-day high-fat, high-calorie diet. We demonstrated that LBW men had higher C2 and C4-OH levels after the control diet compared with NBW men, indicating an increased fatty acid beta-oxidation relative to the tricarboxylic acid cycle flux. Also, they had higher C6-DC, C10-OH/C8-DC, and total hydroxyl-/dicarboxyl-acylcarnitine levels, which may suggest an increased fatty acid omega-oxidation in the liver. Furthermore, LBW and NBW men decreased several acylcarnitine levels in response to overfeeding, which is likely a result of an upregulation of fatty acid oxidation due to the dietary challenge. Moreover, C10-OH/C8-DC and total hydroxyl-/dicarboxyl-acylcarnitine levels tended to be negatively associated with the serum insulin level, and the total hydroxyl-/dicarboxyl-acylcarnitine level additionally tended to be negatively associated with the hepatic insulin resistance index. This indicates that an increased fatty acid omega-oxidation could be a compensatory mechanism to prevent an accumulation of lipid species that impair insulin signaling.

AB - We hypothesized that an increased, incomplete fatty acid beta-oxidation in mitochondria could be part of the metabolic events leading to insulin resistance and thereby an increased type 2 diabetes risk in low birth weight (LBW) compared with normal birth weight (NBW) individuals. Therefore, we measured fasting plasma levels of 45 acylcarnitine species in 18 LBW and 25 NBW men after an isocaloric control diet and a 5-day high-fat, high-calorie diet. We demonstrated that LBW men had higher C2 and C4-OH levels after the control diet compared with NBW men, indicating an increased fatty acid beta-oxidation relative to the tricarboxylic acid cycle flux. Also, they had higher C6-DC, C10-OH/C8-DC, and total hydroxyl-/dicarboxyl-acylcarnitine levels, which may suggest an increased fatty acid omega-oxidation in the liver. Furthermore, LBW and NBW men decreased several acylcarnitine levels in response to overfeeding, which is likely a result of an upregulation of fatty acid oxidation due to the dietary challenge. Moreover, C10-OH/C8-DC and total hydroxyl-/dicarboxyl-acylcarnitine levels tended to be negatively associated with the serum insulin level, and the total hydroxyl-/dicarboxyl-acylcarnitine level additionally tended to be negatively associated with the hepatic insulin resistance index. This indicates that an increased fatty acid omega-oxidation could be a compensatory mechanism to prevent an accumulation of lipid species that impair insulin signaling.

KW - Journal Article

U2 - 10.14814/phy2.12977

DO - 10.14814/phy2.12977

M3 - Journal article

C2 - 27694528

VL - 4

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 19

M1 - e12977

ER -

ID: 179169936

Department of Biomedical Sciences