Molecular Pharmacology of CXCR4 inhibition

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Molecular Pharmacology of CXCR4 inhibition. / Steen, Anne; Rosenkilde, Mette Marie.

Novel Developments in Stem Cell Mobilization : Focus on CXCR4. ed. / Stefan Fruehauf; Jens W. Zeller; Gary Calandra. Springer Science+Business Media, 2012. p. 23-35.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Steen, A & Rosenkilde, MM 2012, Molecular Pharmacology of CXCR4 inhibition. in S Fruehauf, JW Zeller & G Calandra (eds), Novel Developments in Stem Cell Mobilization : Focus on CXCR4. Springer Science+Business Media, pp. 23-35. https://doi.org/10.1007/978-1-4614-1960-0_2

APA

Steen, A., & Rosenkilde, M. M. (2012). Molecular Pharmacology of CXCR4 inhibition. In S. Fruehauf, J. W. Zeller, & G. Calandra (Eds.), Novel Developments in Stem Cell Mobilization : Focus on CXCR4 (pp. 23-35). Springer Science+Business Media. https://doi.org/10.1007/978-1-4614-1960-0_2

Vancouver

Steen A, Rosenkilde MM. Molecular Pharmacology of CXCR4 inhibition. In Fruehauf S, Zeller JW, Calandra G, editors, Novel Developments in Stem Cell Mobilization : Focus on CXCR4. Springer Science+Business Media. 2012. p. 23-35 https://doi.org/10.1007/978-1-4614-1960-0_2

Author

Steen, Anne ; Rosenkilde, Mette Marie. / Molecular Pharmacology of CXCR4 inhibition. Novel Developments in Stem Cell Mobilization : Focus on CXCR4. editor / Stefan Fruehauf ; Jens W. Zeller ; Gary Calandra. Springer Science+Business Media, 2012. pp. 23-35

Bibtex

@inbook{1a5350420eb949b69c221e590cebe59f,
title = "Molecular Pharmacology of CXCR4 inhibition",
abstract = "In recent years, the chemokine receptor CXCR4 has been shown to beimplemented in the mobilization of progenitor cells from the bone marrow. Thisfinding has prompted a search for CXCR4 antagonists acting as stem cell mobilizingagents. In accordance, it is important to look into the molecular pharmacologyof well-known CXCR4 antagonists in order to augment the potency and affinity andto increase the specificity of future CXCR4-targeting compounds. In this chapter,binding modes of CXCR4 antagonists that have been shown to mobilize stem cellsare discussed. In addition, comparisons between results obtained from structure–function studies and findings from newly released crystal structures are drawn.",
author = "Anne Steen and Rosenkilde, {Mette Marie}",
year = "2012",
doi = "10.1007/978-1-4614-1960-0_2",
language = "English",
isbn = "978-1-4614-1959-4",
pages = "23--35",
editor = "Stefan Fruehauf and Zeller, {Jens W.} and Gary Calandra",
booktitle = "Novel Developments in Stem Cell Mobilization",
publisher = "Springer Science+Business Media",
address = "Singapore",

}

RIS

TY - CHAP

T1 - Molecular Pharmacology of CXCR4 inhibition

AU - Steen, Anne

AU - Rosenkilde, Mette Marie

PY - 2012

Y1 - 2012

N2 - In recent years, the chemokine receptor CXCR4 has been shown to beimplemented in the mobilization of progenitor cells from the bone marrow. Thisfinding has prompted a search for CXCR4 antagonists acting as stem cell mobilizingagents. In accordance, it is important to look into the molecular pharmacologyof well-known CXCR4 antagonists in order to augment the potency and affinity andto increase the specificity of future CXCR4-targeting compounds. In this chapter,binding modes of CXCR4 antagonists that have been shown to mobilize stem cellsare discussed. In addition, comparisons between results obtained from structure–function studies and findings from newly released crystal structures are drawn.

AB - In recent years, the chemokine receptor CXCR4 has been shown to beimplemented in the mobilization of progenitor cells from the bone marrow. Thisfinding has prompted a search for CXCR4 antagonists acting as stem cell mobilizingagents. In accordance, it is important to look into the molecular pharmacologyof well-known CXCR4 antagonists in order to augment the potency and affinity andto increase the specificity of future CXCR4-targeting compounds. In this chapter,binding modes of CXCR4 antagonists that have been shown to mobilize stem cellsare discussed. In addition, comparisons between results obtained from structure–function studies and findings from newly released crystal structures are drawn.

U2 - 10.1007/978-1-4614-1960-0_2

DO - 10.1007/978-1-4614-1960-0_2

M3 - Book chapter

SN - 978-1-4614-1959-4

SP - 23

EP - 35

BT - Novel Developments in Stem Cell Mobilization

A2 - Fruehauf, Stefan

A2 - Zeller, Jens W.

A2 - Calandra, Gary

PB - Springer Science+Business Media

ER -

ID: 47964287