Molecular Pharmacology of CXCR4 inhibition
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Molecular Pharmacology of CXCR4 inhibition. / Steen, Anne; Rosenkilde, Mette Marie.
Novel Developments in Stem Cell Mobilization : Focus on CXCR4. ed. / Stefan Fruehauf; Jens W. Zeller; Gary Calandra. Springer Science+Business Media, 2012. p. 23-35.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Molecular Pharmacology of CXCR4 inhibition
AU - Steen, Anne
AU - Rosenkilde, Mette Marie
PY - 2012
Y1 - 2012
N2 - In recent years, the chemokine receptor CXCR4 has been shown to beimplemented in the mobilization of progenitor cells from the bone marrow. Thisfinding has prompted a search for CXCR4 antagonists acting as stem cell mobilizingagents. In accordance, it is important to look into the molecular pharmacologyof well-known CXCR4 antagonists in order to augment the potency and affinity andto increase the specificity of future CXCR4-targeting compounds. In this chapter,binding modes of CXCR4 antagonists that have been shown to mobilize stem cellsare discussed. In addition, comparisons between results obtained from structure–function studies and findings from newly released crystal structures are drawn.
AB - In recent years, the chemokine receptor CXCR4 has been shown to beimplemented in the mobilization of progenitor cells from the bone marrow. Thisfinding has prompted a search for CXCR4 antagonists acting as stem cell mobilizingagents. In accordance, it is important to look into the molecular pharmacologyof well-known CXCR4 antagonists in order to augment the potency and affinity andto increase the specificity of future CXCR4-targeting compounds. In this chapter,binding modes of CXCR4 antagonists that have been shown to mobilize stem cellsare discussed. In addition, comparisons between results obtained from structure–function studies and findings from newly released crystal structures are drawn.
U2 - 10.1007/978-1-4614-1960-0_2
DO - 10.1007/978-1-4614-1960-0_2
M3 - Book chapter
SN - 978-1-4614-1959-4
SP - 23
EP - 35
BT - Novel Developments in Stem Cell Mobilization
A2 - Fruehauf, Stefan
A2 - Zeller, Jens W.
A2 - Calandra, Gary
PB - Springer Science+Business Media
ER -
ID: 47964287