Low prevalence of peripheral arterial disease in a cross-sectional study of Danish HIV-infected patients
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Low prevalence of peripheral arterial disease in a cross-sectional study of Danish HIV-infected patients. / Knudsen, Andreas; Malmberg, Catarina Anna Evelina; Kjær, Andreas; Lebech, Anne-Mette.
In: Infectious Diseases, Vol. 47, No. 11, 2015, p. 776-82.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Low prevalence of peripheral arterial disease in a cross-sectional study of Danish HIV-infected patients
AU - Knudsen, Andreas
AU - Malmberg, Catarina Anna Evelina
AU - Kjær, Andreas
AU - Lebech, Anne-Mette
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Patients infected with human immunodeficiency virus (HIV) appear to be at increased risk of cardiovascular disease (CVD). The ankle-brachial index (ABI) is a well-established screening tool for peripheral arterial disease (PAD) and future cardiovascular events in the general population. However, controversies exist on the prevalence of PAD among HIV-infected patients. In this study we aimed to measure the prevalence of PAD among HIV-infected patients and compare the ABI with carotid intima-media thickness (cIMT) and other known CVD risk predictors.METHODS: We prospectively included HIV-infected patients from an outpatient clinic at the Department of Infectious Diseases, Hvidovre University Hospital, Denmark. We assessed the ABI pre- and post-exercise with a threshold for PAD defined as ABI ≤ 0.9. All patients had cIMT measured at the far wall of the distal common carotid artery.RESULTS: Of 102 patients included (mean age 52 years, 75% male, 94% receiving antiretroviral therapy (ART), 33% active smokers), 1 had a pre-exercise ABI ≤ 0.9 and in addition 3 patients had a post-exercise ABI ≤ 0.9. We found a poor correlation between ABI and traditional CVD risk factors other than body mass index. In contrast, a strong correlation was found between cIMT and traditional risk factors. Values of post-exercise ABI and cIMT were not correlated. The current ART did not influence ABI values.CONCLUSIONS: We found a low prevalence of PAD in HIV-infected patients. ABI did not correlate with CVD risk factors or cIMT. Based on these results ABI does not seem valuable as a screening tool for CVD among HIV-infected patients.
AB - BACKGROUND: Patients infected with human immunodeficiency virus (HIV) appear to be at increased risk of cardiovascular disease (CVD). The ankle-brachial index (ABI) is a well-established screening tool for peripheral arterial disease (PAD) and future cardiovascular events in the general population. However, controversies exist on the prevalence of PAD among HIV-infected patients. In this study we aimed to measure the prevalence of PAD among HIV-infected patients and compare the ABI with carotid intima-media thickness (cIMT) and other known CVD risk predictors.METHODS: We prospectively included HIV-infected patients from an outpatient clinic at the Department of Infectious Diseases, Hvidovre University Hospital, Denmark. We assessed the ABI pre- and post-exercise with a threshold for PAD defined as ABI ≤ 0.9. All patients had cIMT measured at the far wall of the distal common carotid artery.RESULTS: Of 102 patients included (mean age 52 years, 75% male, 94% receiving antiretroviral therapy (ART), 33% active smokers), 1 had a pre-exercise ABI ≤ 0.9 and in addition 3 patients had a post-exercise ABI ≤ 0.9. We found a poor correlation between ABI and traditional CVD risk factors other than body mass index. In contrast, a strong correlation was found between cIMT and traditional risk factors. Values of post-exercise ABI and cIMT were not correlated. The current ART did not influence ABI values.CONCLUSIONS: We found a low prevalence of PAD in HIV-infected patients. ABI did not correlate with CVD risk factors or cIMT. Based on these results ABI does not seem valuable as a screening tool for CVD among HIV-infected patients.
KW - Aged
KW - Ankle Brachial Index
KW - Anti-HIV Agents
KW - Cross-Sectional Studies
KW - Denmark
KW - Female
KW - HIV Infections
KW - Humans
KW - Male
KW - Middle Aged
KW - Peripheral Arterial Disease
KW - Prevalence
KW - Prospective Studies
U2 - 10.3109/23744235.2015.1061204
DO - 10.3109/23744235.2015.1061204
M3 - Journal article
C2 - 26114988
VL - 47
SP - 776
EP - 782
JO - Infectious Diseases
JF - Infectious Diseases
SN - 1178-6337
IS - 11
ER -
ID: 162412878