Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. / Diness, Jonas Goldin; Sørensen, Ulrik S; Nissen, Jakob Dahl; Al-Shahib, Baha; Jespersen, Thomas; Grunnet, Morten; Hansen, Rie Schultz; Jespersen, Thomas.

In: Circulation. Arrhythmia and electrophysiology, Vol. 3, No. 4, 08.2010, p. 380-90.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Diness, JG, Sørensen, US, Nissen, JD, Al-Shahib, B, Jespersen, T, Grunnet, M, Hansen, RS & Jespersen, T 2010, 'Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation', Circulation. Arrhythmia and electrophysiology, vol. 3, no. 4, pp. 380-90. https://doi.org/10.1161/CIRCEP.110.957407

APA

Diness, J. G., Sørensen, U. S., Nissen, J. D., Al-Shahib, B., Jespersen, T., Grunnet, M., Hansen, R. S., & Jespersen, T. (2010). Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. Circulation. Arrhythmia and electrophysiology, 3(4), 380-90. https://doi.org/10.1161/CIRCEP.110.957407

Vancouver

Diness JG, Sørensen US, Nissen JD, Al-Shahib B, Jespersen T, Grunnet M et al. Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. Circulation. Arrhythmia and electrophysiology. 2010 Aug;3(4):380-90. https://doi.org/10.1161/CIRCEP.110.957407

Author

Diness, Jonas Goldin ; Sørensen, Ulrik S ; Nissen, Jakob Dahl ; Al-Shahib, Baha ; Jespersen, Thomas ; Grunnet, Morten ; Hansen, Rie Schultz ; Jespersen, Thomas. / Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. In: Circulation. Arrhythmia and electrophysiology. 2010 ; Vol. 3, No. 4. pp. 380-90.

Bibtex

@article{16b467b8da094f21bbbc8fe958d158ed,
title = "Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation",
abstract = "Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.",
keywords = "1-Naphthylamine, Acetylcholine, Action Potentials, Alkanes, Animals, Anti-Arrhythmia Agents, Atrial Fibrillation, Cardiac Pacing, Artificial, Dose-Response Relationship, Drug, Electrocardiography, Female, Guinea Pigs, Male, Myocardium, Perfusion, Potassium Channel Blockers, Potassium Channels, Calcium-Activated, Pyridines, Quinolinium Compounds, Rabbits, Rats, Rats, Sprague-Dawley, Thiazoles, Time Factors",
author = "Diness, {Jonas Goldin} and S{\o}rensen, {Ulrik S} and Nissen, {Jakob Dahl} and Baha Al-Shahib and Thomas Jespersen and Morten Grunnet and Hansen, {Rie Schultz} and Thomas Jespersen",
year = "2010",
month = aug,
doi = "10.1161/CIRCEP.110.957407",
language = "English",
volume = "3",
pages = "380--90",
journal = "Circulation: Arrhythmia and Electrophysiology",
issn = "1941-3149",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation

AU - Diness, Jonas Goldin

AU - Sørensen, Ulrik S

AU - Nissen, Jakob Dahl

AU - Al-Shahib, Baha

AU - Jespersen, Thomas

AU - Grunnet, Morten

AU - Hansen, Rie Schultz

AU - Jespersen, Thomas

PY - 2010/8

Y1 - 2010/8

N2 - Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.

AB - Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.

KW - 1-Naphthylamine

KW - Acetylcholine

KW - Action Potentials

KW - Alkanes

KW - Animals

KW - Anti-Arrhythmia Agents

KW - Atrial Fibrillation

KW - Cardiac Pacing, Artificial

KW - Dose-Response Relationship, Drug

KW - Electrocardiography

KW - Female

KW - Guinea Pigs

KW - Male

KW - Myocardium

KW - Perfusion

KW - Potassium Channel Blockers

KW - Potassium Channels, Calcium-Activated

KW - Pyridines

KW - Quinolinium Compounds

KW - Rabbits

KW - Rats

KW - Rats, Sprague-Dawley

KW - Thiazoles

KW - Time Factors

U2 - 10.1161/CIRCEP.110.957407

DO - 10.1161/CIRCEP.110.957407

M3 - Journal article

C2 - 20562443

VL - 3

SP - 380

EP - 390

JO - Circulation: Arrhythmia and Electrophysiology

JF - Circulation: Arrhythmia and Electrophysiology

SN - 1941-3149

IS - 4

ER -

ID: 33016849