Incretin hormone secretion over the day

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Incretin hormone secretion over the day. / Ahren, B; Carr, RD; Deacon, Carolyn F.

In: Vitamins and Hormones, Vol. 84, 2010, p. 203-220.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ahren, B, Carr, RD & Deacon, CF 2010, 'Incretin hormone secretion over the day', Vitamins and Hormones, vol. 84, pp. 203-220.

APA

Ahren, B., Carr, RD., & Deacon, C. F. (2010). Incretin hormone secretion over the day. Vitamins and Hormones, 84, 203-220.

Vancouver

Ahren B, Carr RD, Deacon CF. Incretin hormone secretion over the day. Vitamins and Hormones. 2010;84:203-220.

Author

Ahren, B ; Carr, RD ; Deacon, Carolyn F. / Incretin hormone secretion over the day. In: Vitamins and Hormones. 2010 ; Vol. 84. pp. 203-220.

Bibtex

@article{7c0f648d386e48628bc2d2b0d0c0e108,
title = "Incretin hormone secretion over the day",
abstract = "The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to in the afternoon. Finally, whether incretin hormone secretion is altered in disease states is an area with, so far, controversial results in different studies, although some studies have demonstrated reduced incretin hormone secretion in type 2 diabetes. This review summarizes our knowledge on regulation of incretin hormone secretion and its potential changes in disease states.",
author = "B Ahren and RD Carr and Deacon, {Carolyn F.}",
year = "2010",
language = "English",
volume = "84",
pages = "203--220",
journal = "Vitamins and Hormones",
issn = "0083-6729",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Incretin hormone secretion over the day

AU - Ahren, B

AU - Carr, RD

AU - Deacon, Carolyn F.

PY - 2010

Y1 - 2010

N2 - The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to in the afternoon. Finally, whether incretin hormone secretion is altered in disease states is an area with, so far, controversial results in different studies, although some studies have demonstrated reduced incretin hormone secretion in type 2 diabetes. This review summarizes our knowledge on regulation of incretin hormone secretion and its potential changes in disease states.

AB - The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to in the afternoon. Finally, whether incretin hormone secretion is altered in disease states is an area with, so far, controversial results in different studies, although some studies have demonstrated reduced incretin hormone secretion in type 2 diabetes. This review summarizes our knowledge on regulation of incretin hormone secretion and its potential changes in disease states.

M3 - Review

VL - 84

SP - 203

EP - 220

JO - Vitamins and Hormones

JF - Vitamins and Hormones

SN - 0083-6729

ER -

ID: 33724887