In Vivo Radionuclide Generators for Diagnostics and Therapy
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In Vivo Radionuclide Generators for Diagnostics and Therapy. / Edem, Patricia E; Fonslet, Jesper; Kjær, Andreas; Herth, Matthias; Severin, Gregory.
In: Bioinorganic Chemistry and Applications, Vol. 2016, 6148357, 2016, p. 1-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - In Vivo Radionuclide Generators for Diagnostics and Therapy
AU - Edem, Patricia E
AU - Fonslet, Jesper
AU - Kjær, Andreas
AU - Herth, Matthias
AU - Severin, Gregory
PY - 2016
Y1 - 2016
N2 - In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is (212)Pb/(212)Bi, which takes advantage of the extended half-life of (212)Pb to execute a targeted delivery of the therapeutic short-lived α-emitter (212)Bi. Often, as in the case of (81)Rb/(81)Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.
AB - In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is (212)Pb/(212)Bi, which takes advantage of the extended half-life of (212)Pb to execute a targeted delivery of the therapeutic short-lived α-emitter (212)Bi. Often, as in the case of (81)Rb/(81)Kr, chemical changes resulting from the transmutation of the parent are relied upon for diagnostic value. In other instances such as with extended alpha decay chains, chemical changes may lead to unwanted consequences. This article reviews some common and not-so-common in vivo generators with the purpose of understanding their value in medicine and medical research. This is currently relevant in light of a recent push for alpha emitters in targeted therapies, which often come with extended decay chains.
U2 - 10.1155/2016/6148357
DO - 10.1155/2016/6148357
M3 - Journal article
C2 - 28058040
VL - 2016
SP - 1
EP - 9
JO - Bioinorganic Chemistry and Applications
JF - Bioinorganic Chemistry and Applications
SN - 1565-3633
M1 - 6148357
ER -
ID: 172098994