Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model. / Farrell, Helen E; Abraham, Alexander M; Cardin, Rhonda D; Mølleskov-Jensen, Ann-Sofie; Rosenkilde, Mette Marie; Davis-Poynter, Nicholas.

In: Journal of Virology, Vol. 87, No. 7, 04.2013, p. 4112-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Farrell, HE, Abraham, AM, Cardin, RD, Mølleskov-Jensen, A-S, Rosenkilde, MM & Davis-Poynter, N 2013, 'Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model', Journal of Virology, vol. 87, no. 7, pp. 4112-7. https://doi.org/10.1128/JVI.03406-12

APA

Farrell, H. E., Abraham, A. M., Cardin, R. D., Mølleskov-Jensen, A-S., Rosenkilde, M. M., & Davis-Poynter, N. (2013). Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model. Journal of Virology, 87(7), 4112-7. https://doi.org/10.1128/JVI.03406-12

Vancouver

Farrell HE, Abraham AM, Cardin RD, Mølleskov-Jensen A-S, Rosenkilde MM, Davis-Poynter N. Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model. Journal of Virology. 2013 Apr;87(7):4112-7. https://doi.org/10.1128/JVI.03406-12

Author

Farrell, Helen E ; Abraham, Alexander M ; Cardin, Rhonda D ; Mølleskov-Jensen, Ann-Sofie ; Rosenkilde, Mette Marie ; Davis-Poynter, Nicholas. / Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model. In: Journal of Virology. 2013 ; Vol. 87, No. 7. pp. 4112-7.

Bibtex

@article{a7fe020b32ca401b94ca4e0292cd6f75,
title = "Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model",
abstract = "The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly by G protein-dependent signaling conserved with that of M33; in contrast, both G protein-dependent and -independent pathways contribute to the latency phenotypes. A novel M33-dependent replication phenotype in cultured bone marrow macrophages is also described.",
keywords = "Analysis of Variance, Animals, COS Cells, Cercopithecus aethiops, Cytomegalovirus, HEK293 Cells, Humans, Luciferases, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Octoxynol, Phenotype, Receptors, Chemokine, Receptors, G-Protein-Coupled, Salivary Glands, Signal Transduction, Viral Proteins, Viral Tropism, Virus Activation, Virus Latency",
author = "Farrell, {Helen E} and Abraham, {Alexander M} and Cardin, {Rhonda D} and Ann-Sofie M{\o}lleskov-Jensen and Rosenkilde, {Mette Marie} and Nicholas Davis-Poynter",
year = "2013",
month = apr,
doi = "10.1128/JVI.03406-12",
language = "English",
volume = "87",
pages = "4112--7",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "7",

}

RIS

TY - JOUR

T1 - Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model

AU - Farrell, Helen E

AU - Abraham, Alexander M

AU - Cardin, Rhonda D

AU - Mølleskov-Jensen, Ann-Sofie

AU - Rosenkilde, Mette Marie

AU - Davis-Poynter, Nicholas

PY - 2013/4

Y1 - 2013/4

N2 - The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly by G protein-dependent signaling conserved with that of M33; in contrast, both G protein-dependent and -independent pathways contribute to the latency phenotypes. A novel M33-dependent replication phenotype in cultured bone marrow macrophages is also described.

AB - The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly by G protein-dependent signaling conserved with that of M33; in contrast, both G protein-dependent and -independent pathways contribute to the latency phenotypes. A novel M33-dependent replication phenotype in cultured bone marrow macrophages is also described.

KW - Analysis of Variance

KW - Animals

KW - COS Cells

KW - Cercopithecus aethiops

KW - Cytomegalovirus

KW - HEK293 Cells

KW - Humans

KW - Luciferases

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C57BL

KW - Octoxynol

KW - Phenotype

KW - Receptors, Chemokine

KW - Receptors, G-Protein-Coupled

KW - Salivary Glands

KW - Signal Transduction

KW - Viral Proteins

KW - Viral Tropism

KW - Virus Activation

KW - Virus Latency

U2 - 10.1128/JVI.03406-12

DO - 10.1128/JVI.03406-12

M3 - Journal article

C2 - 23345521

VL - 87

SP - 4112

EP - 4117

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 7

ER -

ID: 48972105