Gut: a key player in the pathogenesis of type 2 diabetes?
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Gut : a key player in the pathogenesis of type 2 diabetes? / Muscogiuri, Giovanna; Balercia, Giancarlo; Barrea, Luigi; Cignarelli, Angelo; Giorgino, Francesco; Holst, Jens J; Laudisio, Daniela; Orio, Francesco; Tirabassi, Giacomo; Colao, Annamaria.
In: Critical Reviews in Food Science and Nutrition, Vol. 58, No. 8, 2018, p. 1294–1309.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Gut
T2 - a key player in the pathogenesis of type 2 diabetes?
AU - Muscogiuri, Giovanna
AU - Balercia, Giancarlo
AU - Barrea, Luigi
AU - Cignarelli, Angelo
AU - Giorgino, Francesco
AU - Holst, Jens J
AU - Laudisio, Daniela
AU - Orio, Francesco
AU - Tirabassi, Giacomo
AU - Colao, Annamaria
PY - 2018
Y1 - 2018
N2 - The gut regulates glucose and energy homeostasis; thus, the presence of ingested nutrients into the gut activates sensing mechanisms that affect both glucose homeostasis and regulate food intake. Increasing evidence suggest that gut may also play a key role in the pathogenesis of type 2 diabetes which may be related to both the intestinal microbiological profile and patterns of gut hormones secretion. Intestinal microbiota includes trillions of microorganisms but its composition and function may be adversely affected in type 2 diabetes. The intestinal microbiota may be responsible of the secretion of molecules that may impair insulin secretion/action. At the same time intestinal milieu regulates the secretion of hormones such as GLP-1, GIP, ghrelin, gastrin, somatostatin, CCK, serotonin, peptide YY, GLP-2, all of which importantly influence metabolism in general and in particular glucose metabolism. Thus, the aim of this manuscript is to review the current evidence on the role of the gut in the pathogenesis of type 2 diabetes, taking into account both hormonal and microbiological aspects.
AB - The gut regulates glucose and energy homeostasis; thus, the presence of ingested nutrients into the gut activates sensing mechanisms that affect both glucose homeostasis and regulate food intake. Increasing evidence suggest that gut may also play a key role in the pathogenesis of type 2 diabetes which may be related to both the intestinal microbiological profile and patterns of gut hormones secretion. Intestinal microbiota includes trillions of microorganisms but its composition and function may be adversely affected in type 2 diabetes. The intestinal microbiota may be responsible of the secretion of molecules that may impair insulin secretion/action. At the same time intestinal milieu regulates the secretion of hormones such as GLP-1, GIP, ghrelin, gastrin, somatostatin, CCK, serotonin, peptide YY, GLP-2, all of which importantly influence metabolism in general and in particular glucose metabolism. Thus, the aim of this manuscript is to review the current evidence on the role of the gut in the pathogenesis of type 2 diabetes, taking into account both hormonal and microbiological aspects.
U2 - 10.1080/10408398.2016.1252712
DO - 10.1080/10408398.2016.1252712
M3 - Review
C2 - 27892685
VL - 58
SP - 1294
EP - 1309
JO - Critical Reviews in Food Science and Nutrition
JF - Critical Reviews in Food Science and Nutrition
SN - 1040-8398
IS - 8
ER -
ID: 172514194