Glucagon-like peptide-1: effect on pro-atrial natriuretic peptide in healthy males
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Glucagon-like peptide-1: effect on pro-atrial natriuretic peptide in healthy males. / Skov, Jeppe; Holst, Jens Juul; Gøtze, Jens Peter; Frøkiær, Jørgen; Christiansen, Jens Sandahl.
In: Endocrine Connections, Vol. 3, No. 1, 2014, p. 11-6.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Glucagon-like peptide-1: effect on pro-atrial natriuretic peptide in healthy males
AU - Skov, Jeppe
AU - Holst, Jens Juul
AU - Gøtze, Jens Peter
AU - Frøkiær, Jørgen
AU - Christiansen, Jens Sandahl
PY - 2014
Y1 - 2014
N2 - The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young males in a randomized, controlled, double-blinded, single-day, cross-over study to evaluate the effects of a 2-h native GLP1 infusion. Plasma proANP concentrations were measured by an automated mid-region-directed proANP immunoassay and N-terminal pro B-type natriuretic peptide (BNP) on Roche Modular E170. Urine was collected for measurements of sodium excretion. Although GLP1 infusion increased the urinary sodium excretion markedly, there were no significant changes in either proANP or proBNP concentrations. When GLP1 infusion was stopped, sodium excretion declined rapidly. As proANP concentration reflects ANP secretion, our data could not confirm the existence of a GLP1-ANP axis in humans. Especially, the natriuretic effects of GLP1 seem unlikely to be mediated exclusively via ANP.
AB - The antihypertensive actions of glucagon-like peptide-1 (GLP1) receptor agonists have been linked to the release of atrial natriuretic peptide (ANP) in mice. Whether a GLP1-ANP axis exists in humans is unknown. In this study, we examined 12 healthy young males in a randomized, controlled, double-blinded, single-day, cross-over study to evaluate the effects of a 2-h native GLP1 infusion. Plasma proANP concentrations were measured by an automated mid-region-directed proANP immunoassay and N-terminal pro B-type natriuretic peptide (BNP) on Roche Modular E170. Urine was collected for measurements of sodium excretion. Although GLP1 infusion increased the urinary sodium excretion markedly, there were no significant changes in either proANP or proBNP concentrations. When GLP1 infusion was stopped, sodium excretion declined rapidly. As proANP concentration reflects ANP secretion, our data could not confirm the existence of a GLP1-ANP axis in humans. Especially, the natriuretic effects of GLP1 seem unlikely to be mediated exclusively via ANP.
U2 - 10.1530/EC-13-0087
DO - 10.1530/EC-13-0087
M3 - Journal article
C2 - 24327600
VL - 3
SP - 11
EP - 16
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 1
ER -
ID: 117852866