Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes

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Glucagon-like Peptide-1 and the Central/Peripheral Nervous System : Crosstalk in Diabetes. / Muscogiuri, Giovanna; DeFronzo, Ralph A; Gastaldelli, Amalia; Holst, Jens J.

In: Trends in Endocrinology and Metabolism, Vol. 28, No. 2, 02.2017, p. 88-103.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Muscogiuri, G, DeFronzo, RA, Gastaldelli, A & Holst, JJ 2017, 'Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes', Trends in Endocrinology and Metabolism, vol. 28, no. 2, pp. 88-103. https://doi.org/10.1016/j.tem.2016.10.001

APA

Muscogiuri, G., DeFronzo, R. A., Gastaldelli, A., & Holst, J. J. (2017). Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes. Trends in Endocrinology and Metabolism, 28(2), 88-103. https://doi.org/10.1016/j.tem.2016.10.001

Vancouver

Muscogiuri G, DeFronzo RA, Gastaldelli A, Holst JJ. Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes. Trends in Endocrinology and Metabolism. 2017 Feb;28(2):88-103. https://doi.org/10.1016/j.tem.2016.10.001

Author

Muscogiuri, Giovanna ; DeFronzo, Ralph A ; Gastaldelli, Amalia ; Holst, Jens J. / Glucagon-like Peptide-1 and the Central/Peripheral Nervous System : Crosstalk in Diabetes. In: Trends in Endocrinology and Metabolism. 2017 ; Vol. 28, No. 2. pp. 88-103.

Bibtex

@article{4f871ba680384756bc7323bc62d15a49,
title = "Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes",
abstract = "Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation of neurologic and cognitive functions. These actions are mediated via neurons in the nucleus of the solitary tract that project to multiple regions expressing GLP-1 receptors (GLP-1Rs). Treatment with GLP-1R agonists (GLP-1-RAs) reduces ischemia-induced hyperactivity, oxidative stress, neuronal damage and apoptosis, cerebral infarct volume, and neurologic damage, after cerebral ischemia, in experimental models. Ongoing human trials report a neuroprotective effect of GLP-1-RAs in Alzheimer's and Parkinson's disease. In this review, we discuss the role of GLP-1 and GLP-1-RAs in the nervous system with focus on GLP-1 actions on appetite regulation, glucose homeostasis, and neuroprotection.",
author = "Giovanna Muscogiuri and DeFronzo, {Ralph A} and Amalia Gastaldelli and Holst, {Jens J}",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2017",
month = feb,
doi = "10.1016/j.tem.2016.10.001",
language = "English",
volume = "28",
pages = "88--103",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Ltd. * Trends Journals",
number = "2",

}

RIS

TY - JOUR

T1 - Glucagon-like Peptide-1 and the Central/Peripheral Nervous System

T2 - Crosstalk in Diabetes

AU - Muscogiuri, Giovanna

AU - DeFronzo, Ralph A

AU - Gastaldelli, Amalia

AU - Holst, Jens J

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2017/2

Y1 - 2017/2

N2 - Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation of neurologic and cognitive functions. These actions are mediated via neurons in the nucleus of the solitary tract that project to multiple regions expressing GLP-1 receptors (GLP-1Rs). Treatment with GLP-1R agonists (GLP-1-RAs) reduces ischemia-induced hyperactivity, oxidative stress, neuronal damage and apoptosis, cerebral infarct volume, and neurologic damage, after cerebral ischemia, in experimental models. Ongoing human trials report a neuroprotective effect of GLP-1-RAs in Alzheimer's and Parkinson's disease. In this review, we discuss the role of GLP-1 and GLP-1-RAs in the nervous system with focus on GLP-1 actions on appetite regulation, glucose homeostasis, and neuroprotection.

AB - Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation of neurologic and cognitive functions. These actions are mediated via neurons in the nucleus of the solitary tract that project to multiple regions expressing GLP-1 receptors (GLP-1Rs). Treatment with GLP-1R agonists (GLP-1-RAs) reduces ischemia-induced hyperactivity, oxidative stress, neuronal damage and apoptosis, cerebral infarct volume, and neurologic damage, after cerebral ischemia, in experimental models. Ongoing human trials report a neuroprotective effect of GLP-1-RAs in Alzheimer's and Parkinson's disease. In this review, we discuss the role of GLP-1 and GLP-1-RAs in the nervous system with focus on GLP-1 actions on appetite regulation, glucose homeostasis, and neuroprotection.

U2 - 10.1016/j.tem.2016.10.001

DO - 10.1016/j.tem.2016.10.001

M3 - Review

C2 - 27871675

VL - 28

SP - 88

EP - 103

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 2

ER -

ID: 172765068