Global, regional and national estimates of influenza-attributable ischemic heart disease mortality
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Global, regional and national estimates of influenza-attributable ischemic heart disease mortality. / Chaves, Sandra S.; Nealon, Joshua; Burkart, Katrin G.; Modin, Daniel; Biering-Sørensen, Tor; Ortiz, Justin R.; Vilchis-Tella, Victor M.; Wallace, Lindsey E.; Roth, Gregory; Mahe, Cedric; Brauer, Michael.
In: EClinicalMedicine, Vol. 55, 101740, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Global, regional and national estimates of influenza-attributable ischemic heart disease mortality
AU - Chaves, Sandra S.
AU - Nealon, Joshua
AU - Burkart, Katrin G.
AU - Modin, Daniel
AU - Biering-Sørensen, Tor
AU - Ortiz, Justin R.
AU - Vilchis-Tella, Victor M.
AU - Wallace, Lindsey E.
AU - Roth, Gregory
AU - Mahe, Cedric
AU - Brauer, Michael
N1 - Publisher Copyright: © 2022 The Author(s)
PY - 2023
Y1 - 2023
N2 - Background: Influenza virus infection is associated with incident ischemic heart disease (IHD) events. Here, we estimate the global, regional, and national IHD mortality burden attributable to influenza. Methods: We used vital registration data from deaths in adults ≥50 years (13.2 million IHD deaths as underlying cause) to assess the relationship between influenza activity and IHD mortality in a non-linear meta-regression framework from 2010 to 2019. This derived relationship was then used to estimate the global influenza attributable IHD mortality. We estimated the population attributable fraction (PAF) of influenza for IHD deaths based on the relative risk associated with a given level of weekly influenza test positivity rate and multiplied PAFs by IHD mortality from the Global Burden of Disease study. Findings: Influenza activity was associated with increased risk of IHD mortality across all countries analyzed. The mean PAF of influenza for IHD mortality was 3.9% (95% uncertainty interval [UI] 2.5–5.3%), ranging from <1% to 10%, depending on country and year. Globally, 299,858 IHD deaths (95% UI 191,216–406,809) in adults ≥50 years could be attributed to influenza, with the highest rates per 100,000 population in the Central Europe, Eastern Europe and Central Asia Region (32.3; 95% UI 20.6–43.8), and in the North Africa and Middle East Region (26.7; 95% UI 17–36.2). Interpretation: Influenza may contribute substantially to the burden of IHD. Our results suggest that if there were no influenza, an average of 4% of IHD deaths globally would not occur. Funding: Collaborative study funded by Sanofi Vaccines.
AB - Background: Influenza virus infection is associated with incident ischemic heart disease (IHD) events. Here, we estimate the global, regional, and national IHD mortality burden attributable to influenza. Methods: We used vital registration data from deaths in adults ≥50 years (13.2 million IHD deaths as underlying cause) to assess the relationship between influenza activity and IHD mortality in a non-linear meta-regression framework from 2010 to 2019. This derived relationship was then used to estimate the global influenza attributable IHD mortality. We estimated the population attributable fraction (PAF) of influenza for IHD deaths based on the relative risk associated with a given level of weekly influenza test positivity rate and multiplied PAFs by IHD mortality from the Global Burden of Disease study. Findings: Influenza activity was associated with increased risk of IHD mortality across all countries analyzed. The mean PAF of influenza for IHD mortality was 3.9% (95% uncertainty interval [UI] 2.5–5.3%), ranging from <1% to 10%, depending on country and year. Globally, 299,858 IHD deaths (95% UI 191,216–406,809) in adults ≥50 years could be attributed to influenza, with the highest rates per 100,000 population in the Central Europe, Eastern Europe and Central Asia Region (32.3; 95% UI 20.6–43.8), and in the North Africa and Middle East Region (26.7; 95% UI 17–36.2). Interpretation: Influenza may contribute substantially to the burden of IHD. Our results suggest that if there were no influenza, an average of 4% of IHD deaths globally would not occur. Funding: Collaborative study funded by Sanofi Vaccines.
KW - Cardiovascular
KW - Global disease burden
KW - Influenza
KW - Ischemic heart disease
KW - Mortality
UR - http://www.scopus.com/inward/record.url?scp=85142156660&partnerID=8YFLogxK
U2 - 10.1016/j.eclinm.2022.101740
DO - 10.1016/j.eclinm.2022.101740
M3 - Journal article
C2 - 36425868
AN - SCOPUS:85142156660
VL - 55
JO - EClinicalMedicine
JF - EClinicalMedicine
SN - 2589-5370
M1 - 101740
ER -
ID: 331789588