Genetic variation of macronutrient tolerance in Drosophila melanogaster
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Genetic variation of macronutrient tolerance in Drosophila melanogaster. / Havula, E; Ghazanfar, S; Lamichane, N; Francis, D; Hasygar, K; Liu, Y; Alton, L A; Johnstone, J; Needham, E J; Pulpitel, T; Clark, T; Niranjan, H N; Shang, V; Tong, V; Jiwnani, N; Audia, G; Alves, A N; Sylow, Lykke; Mirth, C; Neely, Greg G; Yang, J; Hietakangas, V; Simpson, S J; Senior, Alistair M.
In: Nature Communications, Vol. 13, 1637, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic variation of macronutrient tolerance in Drosophila melanogaster
AU - Havula, E
AU - Ghazanfar, S
AU - Lamichane, N
AU - Francis, D
AU - Hasygar, K
AU - Liu, Y
AU - Alton, L A
AU - Johnstone, J
AU - Needham, E J
AU - Pulpitel, T
AU - Clark, T
AU - Niranjan, H N
AU - Shang, V
AU - Tong, V
AU - Jiwnani, N
AU - Audia, G
AU - Alves, A N
AU - Sylow, Lykke
AU - Mirth, C
AU - Neely, Greg G
AU - Yang, J
AU - Hietakangas, V
AU - Simpson, S J
AU - Senior, Alistair M
N1 - © 2022. The Author(s).
PY - 2022
Y1 - 2022
N2 - Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.
AB - Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.
U2 - 10.1038/s41467-022-29183-x
DO - 10.1038/s41467-022-29183-x
M3 - Journal article
C2 - 35347148
VL - 13
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 1637
ER -
ID: 301702529