Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels. / Hofsø, Dag; Birkeland, Kåre I; Holst, Jens J; Bollerslev, Jens; Sandbu, Rune; Røislien, Jo; Hjelmesæth, Jøran.

In: Diabetology & Metabolic Syndrome, Vol. 7, 69, 2015, p. 1-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hofsø, D, Birkeland, KI, Holst, JJ, Bollerslev, J, Sandbu, R, Røislien, J & Hjelmesæth, J 2015, 'Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels', Diabetology & Metabolic Syndrome, vol. 7, 69, pp. 1-4. https://doi.org/10.1186/s13098-015-0066-8

APA

Hofsø, D., Birkeland, K. I., Holst, J. J., Bollerslev, J., Sandbu, R., Røislien, J., & Hjelmesæth, J. (2015). Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels. Diabetology & Metabolic Syndrome, 7, 1-4. [69]. https://doi.org/10.1186/s13098-015-0066-8

Vancouver

Hofsø D, Birkeland KI, Holst JJ, Bollerslev J, Sandbu R, Røislien J et al. Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels. Diabetology & Metabolic Syndrome. 2015;7:1-4. 69. https://doi.org/10.1186/s13098-015-0066-8

Author

Hofsø, Dag ; Birkeland, Kåre I ; Holst, Jens J ; Bollerslev, Jens ; Sandbu, Rune ; Røislien, Jo ; Hjelmesæth, Jøran. / Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels. In: Diabetology & Metabolic Syndrome. 2015 ; Vol. 7. pp. 1-4.

Bibtex

@article{ec7810731365446689fd7ee7bf70b572,
title = "Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels",
abstract = "BACKGROUND: Gastric bypass surgery seems to have an effect on glucose metabolism beyond what is mediated through weight reduction. The magnitude of this effect on fasting and post-challenge glucose levels remains unknown.RESULTS: Morbidly obese subjects without known diabetes performed a 75 g oral glucose tolerance test before and after either gastric bypass surgery (n = 64) or an intensive lifestyle intervention programme (n = 55), ClinicalTrials.gov identifier NCT00273104. The age-adjusted effects of the therapeutic procedures and percentage weight change on fasting and 2-h glucose levels at 1 year were explored using multiple linear regression analysis. Mean (SD) serum fasting and 2-h glucose levels at baseline did not differ between the surgery and lifestyle groups. Weight-loss after surgical treatment and lifestyle intervention was 30 (8) and 9 (10) % (p < 0.001). At 1 year, fasting and 2-h glucose levels were significantly lower in the surgery group than in the lifestyle group, 4.7 (0.4) versus 5.4 (0.7) mmol/l and 3.4 (0.8) versus 6.0 (2.4) mmol/l, respectively (both p < 0.001). Gastric bypass and weight-loss had both independent glucose-lowering effects on 2-h glucose levels [B (95 % CI) 1.4 (0.6-2.3) mmol/l and 0.4 (0.1-0.7) mmol/l per 10 % weight-loss, respectively]. Fasting glucose levels were determined by weight change [0.2 (0.1-0.3) mmol/l per 10 % weight-loss] and not by type of treatment.CONCLUSIONS: Gastric bypass surgery has a clinically relevant glucose-lowering effect on post-challenge glucose levels which is seemingly not mediated through weight-loss alone.",
author = "Dag Hofs{\o} and Birkeland, {K{\aa}re I} and Holst, {Jens J} and Jens Bollerslev and Rune Sandbu and Jo R{\o}islien and J{\o}ran Hjelmes{\ae}th",
year = "2015",
doi = "10.1186/s13098-015-0066-8",
language = "English",
volume = "7",
pages = "1--4",
journal = "Diabetology & Metabolic Syndrome",
issn = "1758-5996",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels

AU - Hofsø, Dag

AU - Birkeland, Kåre I

AU - Holst, Jens J

AU - Bollerslev, Jens

AU - Sandbu, Rune

AU - Røislien, Jo

AU - Hjelmesæth, Jøran

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Gastric bypass surgery seems to have an effect on glucose metabolism beyond what is mediated through weight reduction. The magnitude of this effect on fasting and post-challenge glucose levels remains unknown.RESULTS: Morbidly obese subjects without known diabetes performed a 75 g oral glucose tolerance test before and after either gastric bypass surgery (n = 64) or an intensive lifestyle intervention programme (n = 55), ClinicalTrials.gov identifier NCT00273104. The age-adjusted effects of the therapeutic procedures and percentage weight change on fasting and 2-h glucose levels at 1 year were explored using multiple linear regression analysis. Mean (SD) serum fasting and 2-h glucose levels at baseline did not differ between the surgery and lifestyle groups. Weight-loss after surgical treatment and lifestyle intervention was 30 (8) and 9 (10) % (p < 0.001). At 1 year, fasting and 2-h glucose levels were significantly lower in the surgery group than in the lifestyle group, 4.7 (0.4) versus 5.4 (0.7) mmol/l and 3.4 (0.8) versus 6.0 (2.4) mmol/l, respectively (both p < 0.001). Gastric bypass and weight-loss had both independent glucose-lowering effects on 2-h glucose levels [B (95 % CI) 1.4 (0.6-2.3) mmol/l and 0.4 (0.1-0.7) mmol/l per 10 % weight-loss, respectively]. Fasting glucose levels were determined by weight change [0.2 (0.1-0.3) mmol/l per 10 % weight-loss] and not by type of treatment.CONCLUSIONS: Gastric bypass surgery has a clinically relevant glucose-lowering effect on post-challenge glucose levels which is seemingly not mediated through weight-loss alone.

AB - BACKGROUND: Gastric bypass surgery seems to have an effect on glucose metabolism beyond what is mediated through weight reduction. The magnitude of this effect on fasting and post-challenge glucose levels remains unknown.RESULTS: Morbidly obese subjects without known diabetes performed a 75 g oral glucose tolerance test before and after either gastric bypass surgery (n = 64) or an intensive lifestyle intervention programme (n = 55), ClinicalTrials.gov identifier NCT00273104. The age-adjusted effects of the therapeutic procedures and percentage weight change on fasting and 2-h glucose levels at 1 year were explored using multiple linear regression analysis. Mean (SD) serum fasting and 2-h glucose levels at baseline did not differ between the surgery and lifestyle groups. Weight-loss after surgical treatment and lifestyle intervention was 30 (8) and 9 (10) % (p < 0.001). At 1 year, fasting and 2-h glucose levels were significantly lower in the surgery group than in the lifestyle group, 4.7 (0.4) versus 5.4 (0.7) mmol/l and 3.4 (0.8) versus 6.0 (2.4) mmol/l, respectively (both p < 0.001). Gastric bypass and weight-loss had both independent glucose-lowering effects on 2-h glucose levels [B (95 % CI) 1.4 (0.6-2.3) mmol/l and 0.4 (0.1-0.7) mmol/l per 10 % weight-loss, respectively]. Fasting glucose levels were determined by weight change [0.2 (0.1-0.3) mmol/l per 10 % weight-loss] and not by type of treatment.CONCLUSIONS: Gastric bypass surgery has a clinically relevant glucose-lowering effect on post-challenge glucose levels which is seemingly not mediated through weight-loss alone.

U2 - 10.1186/s13098-015-0066-8

DO - 10.1186/s13098-015-0066-8

M3 - Journal article

C2 - 26300987

VL - 7

SP - 1

EP - 4

JO - Diabetology & Metabolic Syndrome

JF - Diabetology & Metabolic Syndrome

SN - 1758-5996

M1 - 69

ER -

ID: 160636757