Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes

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Standard

Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes. / Knudsen, Sine H; Karstoft, Kristian; Winding, Kamilla; Holst, Jens J; Pedersen, Bente K; Solomon, Thomas.

In: Diabetes, Obesity and Metabolism, Vol. 17, No. 2, 02.2015, p. 207-210.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Knudsen, SH, Karstoft, K, Winding, K, Holst, JJ, Pedersen, BK & Solomon, T 2015, 'Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes', Diabetes, Obesity and Metabolism, vol. 17, no. 2, pp. 207-210. https://doi.org/10.1111/dom.12413

APA

Knudsen, S. H., Karstoft, K., Winding, K., Holst, J. J., Pedersen, B. K., & Solomon, T. (2015). Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes. Diabetes, Obesity and Metabolism, 17(2), 207-210. https://doi.org/10.1111/dom.12413

Vancouver

Knudsen SH, Karstoft K, Winding K, Holst JJ, Pedersen BK, Solomon T. Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes. Diabetes, Obesity and Metabolism. 2015 Feb;17(2):207-210. https://doi.org/10.1111/dom.12413

Author

Knudsen, Sine H ; Karstoft, Kristian ; Winding, Kamilla ; Holst, Jens J ; Pedersen, Bente K ; Solomon, Thomas. / Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes. In: Diabetes, Obesity and Metabolism. 2015 ; Vol. 17, No. 2. pp. 207-210.

Bibtex

@article{055e8e2c047e4d0280240ad2ca93b356,

title = "Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes",

abstract = "We determined the effects of exercise on pancreatic endocrine responses to metabolic stimuli in type 2 diabetic (T2D) subjects and examined the influence of the diabetic status. Fourteen subjects underwent a hyperglycaemic clamp with GLP-1 infusion and arginine injection, the morning after a one-hour walk or no exercise. Subjects were stratified by high and low quantiles of fasting plasma glucose (FPG) and HbA1c as well as current use/non-use of anti-diabetic medication. In the entire cohort, exercise did not alter insulin secretion, while glucagon levels were increased in all clamp phases (P < 0.05-P < 0.01). In low FPG subjects, exercise increased GLP-1-stimulated insulin secretion (P < 0.05) with the same trend for arginine (P = 0.08). The same trends were seen for low HbA1c subjects. Furthermore, exercise increased GLP-1- and arginine-stimulated insulin secretion (P < 0.05) in anti-diabetic drug na{\"i}ve subjects. Exercise-induced increases in insulin secretion are blunted in T2D subjects with high hyperglycaemia and in those using anti-diabetic drugs. Clinical Trials Registration Number: NCT01812590.",

author = "Knudsen, {Sine H} and Kristian Karstoft and Kamilla Winding and Holst, {Jens J} and Pedersen, {Bente K} and Thomas Solomon",

year = "2015",

month = feb,

doi = "10.1111/dom.12413",

language = "English",

volume = "17",

pages = "207--210",

journal = "Diabetes, Obesity and Metabolism",

issn = "1462-8902",

publisher = "Wiley-Blackwell",

number = "2",

}

RIS

TY - JOUR

T1 - Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes

AU - Knudsen, Sine H

AU - Karstoft, Kristian

AU - Winding, Kamilla

AU - Holst, Jens J

AU - Pedersen, Bente K

AU - Solomon, Thomas

PY - 2015/2

Y1 - 2015/2

N2 - We determined the effects of exercise on pancreatic endocrine responses to metabolic stimuli in type 2 diabetic (T2D) subjects and examined the influence of the diabetic status. Fourteen subjects underwent a hyperglycaemic clamp with GLP-1 infusion and arginine injection, the morning after a one-hour walk or no exercise. Subjects were stratified by high and low quantiles of fasting plasma glucose (FPG) and HbA1c as well as current use/non-use of anti-diabetic medication. In the entire cohort, exercise did not alter insulin secretion, while glucagon levels were increased in all clamp phases (P < 0.05-P < 0.01). In low FPG subjects, exercise increased GLP-1-stimulated insulin secretion (P < 0.05) with the same trend for arginine (P = 0.08). The same trends were seen for low HbA1c subjects. Furthermore, exercise increased GLP-1- and arginine-stimulated insulin secretion (P < 0.05) in anti-diabetic drug naïve subjects. Exercise-induced increases in insulin secretion are blunted in T2D subjects with high hyperglycaemia and in those using anti-diabetic drugs. Clinical Trials Registration Number: NCT01812590.

AB - We determined the effects of exercise on pancreatic endocrine responses to metabolic stimuli in type 2 diabetic (T2D) subjects and examined the influence of the diabetic status. Fourteen subjects underwent a hyperglycaemic clamp with GLP-1 infusion and arginine injection, the morning after a one-hour walk or no exercise. Subjects were stratified by high and low quantiles of fasting plasma glucose (FPG) and HbA1c as well as current use/non-use of anti-diabetic medication. In the entire cohort, exercise did not alter insulin secretion, while glucagon levels were increased in all clamp phases (P < 0.05-P < 0.01). In low FPG subjects, exercise increased GLP-1-stimulated insulin secretion (P < 0.05) with the same trend for arginine (P = 0.08). The same trends were seen for low HbA1c subjects. Furthermore, exercise increased GLP-1- and arginine-stimulated insulin secretion (P < 0.05) in anti-diabetic drug naïve subjects. Exercise-induced increases in insulin secretion are blunted in T2D subjects with high hyperglycaemia and in those using anti-diabetic drugs. Clinical Trials Registration Number: NCT01812590.

U2 - 10.1111/dom.12413

DO - 10.1111/dom.12413

M3 - Letter

C2 - 25406646

VL - 17

SP - 207

EP - 210

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 2

ER -

ID: 128481298

Department of Biomedical Sciences