Effect of gastrin on liver regeneration after partial hepatectomy in rats

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Effect of gastrin on liver regeneration after partial hepatectomy in rats. / Poulsen, Steen Seier; Olsen, P S.

In: Gut, Vol. 31, No. 1, 01.1990, p. 92-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS & Olsen, PS 1990, 'Effect of gastrin on liver regeneration after partial hepatectomy in rats', Gut, vol. 31, no. 1, pp. 92-5.

APA

Poulsen, S. S., & Olsen, P. S. (1990). Effect of gastrin on liver regeneration after partial hepatectomy in rats. Gut, 31(1), 92-5.

Vancouver

Poulsen SS, Olsen PS. Effect of gastrin on liver regeneration after partial hepatectomy in rats. Gut. 1990 Jan;31(1):92-5.

Author

Poulsen, Steen Seier ; Olsen, P S. / Effect of gastrin on liver regeneration after partial hepatectomy in rats. In: Gut. 1990 ; Vol. 31, No. 1. pp. 92-5.

Bibtex

@article{f440fa1ec0054eb8baf3712286732003,
title = "Effect of gastrin on liver regeneration after partial hepatectomy in rats",
abstract = "Gastrin has been shown to be an important trophic hormone for the mucosa of the stomach and the proximal intestine. In the present study the effect of gastrin on liver regeneration after partial hepatectomy in rats was investigated. After partial hepatectomy a significant rise in the concentration of gastrin in portal venous blood was found six, 12, and 18 hours after 70% hepatectomy. The effect of changes in the endogenous gastrin concentration on the liver regeneration was investigated in rats subjected to antrectomy or to fundectomy. Partial hepatectomy was done three weeks after the primary surgery. We found antrectomy to decrease liver regeneration, whereas fundectomy had no effect. Administration of pentagastrin 300 micrograms/kg sc three times daily for two and four days after partial hepatectomy significantly increased the rate of liver regeneration compared with controls. This study suggests that gastrin has a hepatotrophic effect. Whether this effect is caused by a direct action of gastrin on the hepatocytes or it is an indirect effect mediated by for instance insulin, glucagon or epidermal growth factor has to be further investigated.",
keywords = "Animals, DNA, Gastrins, Hepatectomy, Liver, Liver Regeneration, Male, Organ Size, Pentagastrin, Pyloric Antrum, Rats, Rats, Inbred Strains, Time Factors",
author = "Poulsen, {Steen Seier} and Olsen, {P S}",
year = "1990",
month = jan,
language = "English",
volume = "31",
pages = "92--5",
journal = "Gut",
issn = "0017-5749",
publisher = "B M J Group",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of gastrin on liver regeneration after partial hepatectomy in rats

AU - Poulsen, Steen Seier

AU - Olsen, P S

PY - 1990/1

Y1 - 1990/1

N2 - Gastrin has been shown to be an important trophic hormone for the mucosa of the stomach and the proximal intestine. In the present study the effect of gastrin on liver regeneration after partial hepatectomy in rats was investigated. After partial hepatectomy a significant rise in the concentration of gastrin in portal venous blood was found six, 12, and 18 hours after 70% hepatectomy. The effect of changes in the endogenous gastrin concentration on the liver regeneration was investigated in rats subjected to antrectomy or to fundectomy. Partial hepatectomy was done three weeks after the primary surgery. We found antrectomy to decrease liver regeneration, whereas fundectomy had no effect. Administration of pentagastrin 300 micrograms/kg sc three times daily for two and four days after partial hepatectomy significantly increased the rate of liver regeneration compared with controls. This study suggests that gastrin has a hepatotrophic effect. Whether this effect is caused by a direct action of gastrin on the hepatocytes or it is an indirect effect mediated by for instance insulin, glucagon or epidermal growth factor has to be further investigated.

AB - Gastrin has been shown to be an important trophic hormone for the mucosa of the stomach and the proximal intestine. In the present study the effect of gastrin on liver regeneration after partial hepatectomy in rats was investigated. After partial hepatectomy a significant rise in the concentration of gastrin in portal venous blood was found six, 12, and 18 hours after 70% hepatectomy. The effect of changes in the endogenous gastrin concentration on the liver regeneration was investigated in rats subjected to antrectomy or to fundectomy. Partial hepatectomy was done three weeks after the primary surgery. We found antrectomy to decrease liver regeneration, whereas fundectomy had no effect. Administration of pentagastrin 300 micrograms/kg sc three times daily for two and four days after partial hepatectomy significantly increased the rate of liver regeneration compared with controls. This study suggests that gastrin has a hepatotrophic effect. Whether this effect is caused by a direct action of gastrin on the hepatocytes or it is an indirect effect mediated by for instance insulin, glucagon or epidermal growth factor has to be further investigated.

KW - Animals

KW - DNA

KW - Gastrins

KW - Hepatectomy

KW - Liver

KW - Liver Regeneration

KW - Male

KW - Organ Size

KW - Pentagastrin

KW - Pyloric Antrum

KW - Rats

KW - Rats, Inbred Strains

KW - Time Factors

M3 - Journal article

C2 - 2318436

VL - 31

SP - 92

EP - 95

JO - Gut

JF - Gut

SN - 0017-5749

IS - 1

ER -

ID: 47488178