Does gut microbiota affect atrial rhythm? Causalities and speculations

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Does gut microbiota affect atrial rhythm? Causalities and speculations. / Linz, Dominik; Gawałko, Monika; Sanders, Prashanthan; Penders, John; Li, Na; Nattel, Stanley; Dobrev, Dobromir.

In: European Heart Journal, Vol. 42, No. 35, 2021, p. 3521-3525.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Linz, D, Gawałko, M, Sanders, P, Penders, J, Li, N, Nattel, S & Dobrev, D 2021, 'Does gut microbiota affect atrial rhythm? Causalities and speculations', European Heart Journal, vol. 42, no. 35, pp. 3521-3525. https://doi.org/10.1093/eurheartj/ehab467

APA

Linz, D., Gawałko, M., Sanders, P., Penders, J., Li, N., Nattel, S., & Dobrev, D. (2021). Does gut microbiota affect atrial rhythm? Causalities and speculations. European Heart Journal, 42(35), 3521-3525. https://doi.org/10.1093/eurheartj/ehab467

Vancouver

Linz D, Gawałko M, Sanders P, Penders J, Li N, Nattel S et al. Does gut microbiota affect atrial rhythm? Causalities and speculations. European Heart Journal. 2021;42(35):3521-3525. https://doi.org/10.1093/eurheartj/ehab467

Author

Linz, Dominik ; Gawałko, Monika ; Sanders, Prashanthan ; Penders, John ; Li, Na ; Nattel, Stanley ; Dobrev, Dobromir. / Does gut microbiota affect atrial rhythm? Causalities and speculations. In: European Heart Journal. 2021 ; Vol. 42, No. 35. pp. 3521-3525.

Bibtex

@article{6bdc790d9f5546149e85e9d59ab98887,
title = "Does gut microbiota affect atrial rhythm? Causalities and speculations",
abstract = "Dietary intake has been shown to change the composition of gut microbiota and some changes in microbiota (dysbiosis) have been linked to diabetes, hypertension, and obesity, which are established risk factors for atrial fibrillation (AF). In addition, intestinal dysbiosis generates microbiota-derived bioactive metabolites that might exert proarrhythmic actions. Although emerging preclinical investigations and clinical observational cohort studies suggest a possible role of gut dysbiosis in AF promotion, the exact mechanisms through which dysbiosis contributes to AF remain unclear. This Viewpoint article briefly reviews evidence suggesting that abnormalities in the intestinal microbiota play an important and little-recognized role in the pathophysiology of AF and that an improved understanding of this role may open up new possibilities in the management of AF.",
keywords = "Arrhythmia, Atrial fibrillation, cardiometabolic, dysbiosis, gut microbiota, metabolites",
author = "Dominik Linz and Monika Gawa{\l}ko and Prashanthan Sanders and John Penders and Na Li and Stanley Nattel and Dobromir Dobrev",
year = "2021",
doi = "10.1093/eurheartj/ehab467",
language = "English",
volume = "42",
pages = "3521--3525",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "35",

}

RIS

TY - JOUR

T1 - Does gut microbiota affect atrial rhythm? Causalities and speculations

AU - Linz, Dominik

AU - Gawałko, Monika

AU - Sanders, Prashanthan

AU - Penders, John

AU - Li, Na

AU - Nattel, Stanley

AU - Dobrev, Dobromir

PY - 2021

Y1 - 2021

N2 - Dietary intake has been shown to change the composition of gut microbiota and some changes in microbiota (dysbiosis) have been linked to diabetes, hypertension, and obesity, which are established risk factors for atrial fibrillation (AF). In addition, intestinal dysbiosis generates microbiota-derived bioactive metabolites that might exert proarrhythmic actions. Although emerging preclinical investigations and clinical observational cohort studies suggest a possible role of gut dysbiosis in AF promotion, the exact mechanisms through which dysbiosis contributes to AF remain unclear. This Viewpoint article briefly reviews evidence suggesting that abnormalities in the intestinal microbiota play an important and little-recognized role in the pathophysiology of AF and that an improved understanding of this role may open up new possibilities in the management of AF.

AB - Dietary intake has been shown to change the composition of gut microbiota and some changes in microbiota (dysbiosis) have been linked to diabetes, hypertension, and obesity, which are established risk factors for atrial fibrillation (AF). In addition, intestinal dysbiosis generates microbiota-derived bioactive metabolites that might exert proarrhythmic actions. Although emerging preclinical investigations and clinical observational cohort studies suggest a possible role of gut dysbiosis in AF promotion, the exact mechanisms through which dysbiosis contributes to AF remain unclear. This Viewpoint article briefly reviews evidence suggesting that abnormalities in the intestinal microbiota play an important and little-recognized role in the pathophysiology of AF and that an improved understanding of this role may open up new possibilities in the management of AF.

KW - Arrhythmia

KW - Atrial fibrillation

KW - cardiometabolic

KW - dysbiosis

KW - gut microbiota

KW - metabolites

U2 - 10.1093/eurheartj/ehab467

DO - 10.1093/eurheartj/ehab467

M3 - Journal article

C2 - 34338744

AN - SCOPUS:85116958374

VL - 42

SP - 3521

EP - 3525

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 35

ER -

ID: 285241524