Distribution of i.v. administered epidermal growth factor in the rat

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Distribution of i.v. administered epidermal growth factor in the rat. / Poulsen, Steen Seier; Nexø, Ebba.

In: Regulatory Peptides, Vol. 23, No. 2, 11.1988, p. 161-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS & Nexø, E 1988, 'Distribution of i.v. administered epidermal growth factor in the rat', Regulatory Peptides, vol. 23, no. 2, pp. 161-9.

APA

Poulsen, S. S., & Nexø, E. (1988). Distribution of i.v. administered epidermal growth factor in the rat. Regulatory Peptides, 23(2), 161-9.

Vancouver

Poulsen SS, Nexø E. Distribution of i.v. administered epidermal growth factor in the rat. Regulatory Peptides. 1988 Nov;23(2):161-9.

Author

Poulsen, Steen Seier ; Nexø, Ebba. / Distribution of i.v. administered epidermal growth factor in the rat. In: Regulatory Peptides. 1988 ; Vol. 23, No. 2. pp. 161-9.

Bibtex

@article{547ac5501476487c86af290bd9cc0769,
title = "Distribution of i.v. administered epidermal growth factor in the rat",
abstract = "The distribution of i.v. injected 125I-labeled epidermal growth factor (EGF) was examined in the rat. The uptake of radioactivity was examined for the following tissues: liver, kidney, skin, stomach, small intestine, colon, brain, submandibular gland, lung, spleen, and testis. 125I-EGF was cleared from the circulation within minutes. At 2.5 min after the injection only 7% of the label was left in the blood. Most of the label was found in the liver (52%), the kidneys (14%), the small intestine (11%) and the skin (7%). The other organs examined contained 1% or less of the radioactivity. The uptake of 125I-EGF per g tissue was markedly higher for the liver and kidneys than for the rest of the organs. By autoradiography 125I-EGF was found in the peripheral parts of the classical liver lobule, in the proximal tubules of the kidneys, in the surface epithelium of the stomach, and in the surface epithelium of the villi in the small intestine. In conclusion the present study showed that small doses of homologous EGF was cleared from the circulation of rats within minutes, mainly by the liver, the kidneys, and the small intestine.",
keywords = "Animals, Autoradiography, Epidermal Growth Factor, Infusions, Intravenous, Intestine, Small, Iodine Radioisotopes, Kidney, Liver, Male, Rats, Rats, Inbred Strains, Skin, Stomach",
author = "Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1988",
month = nov,
language = "English",
volume = "23",
pages = "161--9",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Distribution of i.v. administered epidermal growth factor in the rat

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1988/11

Y1 - 1988/11

N2 - The distribution of i.v. injected 125I-labeled epidermal growth factor (EGF) was examined in the rat. The uptake of radioactivity was examined for the following tissues: liver, kidney, skin, stomach, small intestine, colon, brain, submandibular gland, lung, spleen, and testis. 125I-EGF was cleared from the circulation within minutes. At 2.5 min after the injection only 7% of the label was left in the blood. Most of the label was found in the liver (52%), the kidneys (14%), the small intestine (11%) and the skin (7%). The other organs examined contained 1% or less of the radioactivity. The uptake of 125I-EGF per g tissue was markedly higher for the liver and kidneys than for the rest of the organs. By autoradiography 125I-EGF was found in the peripheral parts of the classical liver lobule, in the proximal tubules of the kidneys, in the surface epithelium of the stomach, and in the surface epithelium of the villi in the small intestine. In conclusion the present study showed that small doses of homologous EGF was cleared from the circulation of rats within minutes, mainly by the liver, the kidneys, and the small intestine.

AB - The distribution of i.v. injected 125I-labeled epidermal growth factor (EGF) was examined in the rat. The uptake of radioactivity was examined for the following tissues: liver, kidney, skin, stomach, small intestine, colon, brain, submandibular gland, lung, spleen, and testis. 125I-EGF was cleared from the circulation within minutes. At 2.5 min after the injection only 7% of the label was left in the blood. Most of the label was found in the liver (52%), the kidneys (14%), the small intestine (11%) and the skin (7%). The other organs examined contained 1% or less of the radioactivity. The uptake of 125I-EGF per g tissue was markedly higher for the liver and kidneys than for the rest of the organs. By autoradiography 125I-EGF was found in the peripheral parts of the classical liver lobule, in the proximal tubules of the kidneys, in the surface epithelium of the stomach, and in the surface epithelium of the villi in the small intestine. In conclusion the present study showed that small doses of homologous EGF was cleared from the circulation of rats within minutes, mainly by the liver, the kidneys, and the small intestine.

KW - Animals

KW - Autoradiography

KW - Epidermal Growth Factor

KW - Infusions, Intravenous

KW - Intestine, Small

KW - Iodine Radioisotopes

KW - Kidney

KW - Liver

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Skin

KW - Stomach

M3 - Journal article

C2 - 3266016

VL - 23

SP - 161

EP - 169

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 2

ER -

ID: 47488294