Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
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Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity. / Christensen, Anders; Wessel, Irene; Charabi, Birgitte Wittenborg; Juhl, Karina; Kiss, Katalin; Lelkaitis, Giedrius; Mortensen, Jann; Kjaer, Andreas; von Buchwald, Christian; Tvedskov, Jesper Filtenborg.
In: European Archives of Oto-Rhino-Laryngology, Vol. 280, 2023, p. 3393–3403.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
AU - Christensen, Anders
AU - Wessel, Irene
AU - Charabi, Birgitte Wittenborg
AU - Juhl, Karina
AU - Kiss, Katalin
AU - Lelkaitis, Giedrius
AU - Mortensen, Jann
AU - Kjaer, Andreas
AU - von Buchwald, Christian
AU - Tvedskov, Jesper Filtenborg
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Purpose: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity. Methods: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up. Results: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%. Conclusion: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
AB - Purpose: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity. Methods: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up. Results: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%. Conclusion: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
KW - Indocyanine green
KW - Near-infrared optical imaging
KW - Neck metastasis
KW - Oral squamous cell carcinoma
KW - Sentinel node biopsy
U2 - 10.1007/s00405-023-07939-5
DO - 10.1007/s00405-023-07939-5
M3 - Journal article
C2 - 37010601
AN - SCOPUS:85151521735
VL - 280
SP - 3393
EP - 3403
JO - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde
JF - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde
SN - 0942-8992
ER -
ID: 345124207