Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

Research output: Contribution to journal › Journal article › Commissioned › peer-review

Standard

Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. / Rayner, Benjamin S; Love, Dominic T; Hawkins, Clare L.

In: Free Radical Biology & Medicine, Vol. 71, 06.2014, p. 240-55.

Research output: Contribution to journal › Journal article › Commissioned › peer-review

Harvard

Rayner, BS, Love, DT & Hawkins, CL 2014, 'Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells', Free Radical Biology & Medicine, vol. 71, pp. 240-55. https://doi.org/10.1016/j.freeradbiomed.2014.03.004

APA

Rayner, B. S., Love, D. T., & Hawkins, C. L. (2014). Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology & Medicine, 71, 240-55. https://doi.org/10.1016/j.freeradbiomed.2014.03.004

Vancouver

Rayner BS, Love DT, Hawkins CL. Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology & Medicine. 2014 Jun;71:240-55. https://doi.org/10.1016/j.freeradbiomed.2014.03.004

Author

Rayner, Benjamin S ; Love, Dominic T ; Hawkins, Clare L. / Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. In: Free Radical Biology & Medicine. 2014 ; Vol. 71. pp. 240-55.

Bibtex

@article{ac12cc15acbd45d983da353cf33d3cda,
title = "Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells",
abstract = "Myeloperoxidase is an important heme enzyme released by activated leukocytes that catalyzes the reaction of hydrogen peroxide with halide and pseudo-halide ions to form various hypohalous acids. Hypohalous acids are chemical oxidants that have potent antibacterial, antiviral, and antifungal properties and, as such, play key roles in the human immune system. However, increasing evidence supports an alternative role for myeloperoxidase-derived oxidants in the development of disease. Excessive production of hypohalous acids, particularly during chronic inflammation, leads to the initiation and accumulation of cellular damage that has been implicated in many human pathologies including atherosclerosis, neurodegenerative disease, lung disease, arthritis, inflammatory cancers, and kidney disease. This has sparked a significant interest in developing a greater understanding of the mechanisms involved in myeloperoxidase-derived oxidant-induced mammalian cell damage. This article reviews recent developments in our understanding of the cellular reactivity of hypochlorous acid, hypobromous acid, and hypothiocyanous acid, the major oxidants produced by myeloperoxidase under physiological conditions.",
keywords = "Animals, Bromates, Calcium, Endothelial Cells, Epithelial Cells, Erythrocytes, Humans, Hydrogen Peroxide, Hypochlorous Acid, Inflammation, Intracellular Signaling Peptides and Proteins, Oxidants, Oxidative Stress, Peroxidase, Signal Transduction, Thiocyanates, Comparative Study, Journal Article, Review",
author = "Rayner, {Benjamin S} and Love, {Dominic T} and Hawkins, {Clare L}",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
month = jun,
doi = "10.1016/j.freeradbiomed.2014.03.004",
language = "English",
volume = "71",
pages = "240--55",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

AU - Rayner, Benjamin S

AU - Love, Dominic T

AU - Hawkins, Clare L

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/6

Y1 - 2014/6

N2 - Myeloperoxidase is an important heme enzyme released by activated leukocytes that catalyzes the reaction of hydrogen peroxide with halide and pseudo-halide ions to form various hypohalous acids. Hypohalous acids are chemical oxidants that have potent antibacterial, antiviral, and antifungal properties and, as such, play key roles in the human immune system. However, increasing evidence supports an alternative role for myeloperoxidase-derived oxidants in the development of disease. Excessive production of hypohalous acids, particularly during chronic inflammation, leads to the initiation and accumulation of cellular damage that has been implicated in many human pathologies including atherosclerosis, neurodegenerative disease, lung disease, arthritis, inflammatory cancers, and kidney disease. This has sparked a significant interest in developing a greater understanding of the mechanisms involved in myeloperoxidase-derived oxidant-induced mammalian cell damage. This article reviews recent developments in our understanding of the cellular reactivity of hypochlorous acid, hypobromous acid, and hypothiocyanous acid, the major oxidants produced by myeloperoxidase under physiological conditions.

AB - Myeloperoxidase is an important heme enzyme released by activated leukocytes that catalyzes the reaction of hydrogen peroxide with halide and pseudo-halide ions to form various hypohalous acids. Hypohalous acids are chemical oxidants that have potent antibacterial, antiviral, and antifungal properties and, as such, play key roles in the human immune system. However, increasing evidence supports an alternative role for myeloperoxidase-derived oxidants in the development of disease. Excessive production of hypohalous acids, particularly during chronic inflammation, leads to the initiation and accumulation of cellular damage that has been implicated in many human pathologies including atherosclerosis, neurodegenerative disease, lung disease, arthritis, inflammatory cancers, and kidney disease. This has sparked a significant interest in developing a greater understanding of the mechanisms involved in myeloperoxidase-derived oxidant-induced mammalian cell damage. This article reviews recent developments in our understanding of the cellular reactivity of hypochlorous acid, hypobromous acid, and hypothiocyanous acid, the major oxidants produced by myeloperoxidase under physiological conditions.

KW - Animals

KW - Bromates

KW - Calcium

KW - Endothelial Cells

KW - Epithelial Cells

KW - Erythrocytes

KW - Humans

KW - Hydrogen Peroxide

KW - Hypochlorous Acid

KW - Inflammation

KW - Intracellular Signaling Peptides and Proteins

KW - Oxidants

KW - Oxidative Stress

KW - Peroxidase

KW - Signal Transduction

KW - Thiocyanates

KW - Comparative Study

KW - Journal Article

KW - Review

U2 - 10.1016/j.freeradbiomed.2014.03.004

DO - 10.1016/j.freeradbiomed.2014.03.004

M3 - Journal article

C2 - 24632382

VL - 71

SP - 240

EP - 255

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

ER -

ID: 174497094