Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

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Standard

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men : a randomized crossover trial. / Canfora, Emanuel E; van der Beek, Christina M; Jocken, Johan W E; Goossens, Gijs H; Holst, Jens J; Olde Damink, Steven W M; Lenaerts, Kaatje; Dejong, Cornelis H C; Blaak, Ellen E.

In: Scientific Reports, Vol. 7, 2360, 24.05.2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Canfora, EE, van der Beek, CM, Jocken, JWE, Goossens, GH, Holst, JJ, Olde Damink, SWM, Lenaerts, K, Dejong, CHC & Blaak, EE 2017, 'Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial', Scientific Reports, vol. 7, 2360. https://doi.org/10.1038/s41598-017-02546-x

APA

Canfora, E. E., van der Beek, C. M., Jocken, J. W. E., Goossens, G. H., Holst, J. J., Olde Damink, S. W. M., Lenaerts, K., Dejong, C. H. C., & Blaak, E. E. (2017). Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Scientific Reports, 7, [2360]. https://doi.org/10.1038/s41598-017-02546-x

Vancouver

Canfora EE, van der Beek CM, Jocken JWE, Goossens GH, Holst JJ, Olde Damink SWM et al. Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Scientific Reports. 2017 May 24;7. 2360. https://doi.org/10.1038/s41598-017-02546-x

Author

Canfora, Emanuel E ; van der Beek, Christina M ; Jocken, Johan W E ; Goossens, Gijs H ; Holst, Jens J ; Olde Damink, Steven W M ; Lenaerts, Kaatje ; Dejong, Cornelis H C ; Blaak, Ellen E. / Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men : a randomized crossover trial. In: Scientific Reports. 2017 ; Vol. 7.

Bibtex

@article{95ee1039ba3a4fd7a7b4782a048d4ac9,
title = "Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial",
abstract = "Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25-35 kg/m(2)) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.",
keywords = "Journal Article",
author = "Canfora, {Emanuel E} and {van der Beek}, {Christina M} and Jocken, {Johan W E} and Goossens, {Gijs H} and Holst, {Jens J} and {Olde Damink}, {Steven W M} and Kaatje Lenaerts and Dejong, {Cornelis H C} and Blaak, {Ellen E}",
year = "2017",
month = may,
day = "24",
doi = "10.1038/s41598-017-02546-x",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men

T2 - a randomized crossover trial

AU - Canfora, Emanuel E

AU - van der Beek, Christina M

AU - Jocken, Johan W E

AU - Goossens, Gijs H

AU - Holst, Jens J

AU - Olde Damink, Steven W M

AU - Lenaerts, Kaatje

AU - Dejong, Cornelis H C

AU - Blaak, Ellen E

PY - 2017/5/24

Y1 - 2017/5/24

N2 - Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25-35 kg/m(2)) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.

AB - Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25-35 kg/m(2)) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.

KW - Journal Article

U2 - 10.1038/s41598-017-02546-x

DO - 10.1038/s41598-017-02546-x

M3 - Journal article

C2 - 28539646

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 2360

ER -

ID: 182889059