Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine

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Standard

Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine. / Vinter-Jensen, Lars; Smerup, Morten Holdgaard; Kissmeyer-Nielsen, Peter; Poulsen, Steen Seier.

In: Regulatory Peptides, Vol. 60, No. 2-3, 14.12.1995, p. 117-24.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vinter-Jensen, L, Smerup, MH, Kissmeyer-Nielsen, P & Poulsen, SS 1995, 'Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine', Regulatory Peptides, vol. 60, no. 2-3, pp. 117-24.

APA

Vinter-Jensen, L., Smerup, M. H., Kissmeyer-Nielsen, P., & Poulsen, S. S. (1995). Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine. Regulatory Peptides, 60(2-3), 117-24.

Vancouver

Vinter-Jensen L, Smerup MH, Kissmeyer-Nielsen P, Poulsen SS. Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine. Regulatory Peptides. 1995 Dec 14;60(2-3):117-24.

Author

Vinter-Jensen, Lars ; Smerup, Morten Holdgaard ; Kissmeyer-Nielsen, Peter ; Poulsen, Steen Seier. / Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine. In: Regulatory Peptides. 1995 ; Vol. 60, No. 2-3. pp. 117-24.

Bibtex

@article{207b30048fb644368926e758e4867595,
title = "Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine",
abstract = "We examined the effects of treatment with human recombinant epidermal growth factor (EGF) on the functioning small intestine in the rat. Male Wistar rats, 7-8 weeks old, were treated with EGF administered subcutaneously in doses of 0 (n = 7) or 150 micrograms/kg/day (n = 8) for 4 weeks. The histological composition and mucosal surface area of the perfusion-fixed small intestine was quantified with stereological principles. The length of the gut remained unchanged. The amount of tissue and surface area per length of gut (median (ranges)) were increased from 117 (101-131) mg/cm and 2.6 (2.1-3.5) cm2/cm in the controls to 146 (138-152) mg/cm and 3.5 (2.5-3.8) cm2/cm for the complete small intestine (both comparisons P <0.02). The weight increase was due to mucosal growth in all parts of the intestine, whereas the surface area was only increased in proximal and middle parts. It is concluded that EGF treatment in rats increases the mucosal weight and surface area of the functioning small intestine.",
keywords = "Animals, Epidermal Growth Factor, Intestinal Mucosa, Intestine, Small, Male, Random Allocation, Rats, Rats, Wistar, Recombinant Proteins, Surface Properties, Time Factors",
author = "Lars Vinter-Jensen and Smerup, {Morten Holdgaard} and Peter Kissmeyer-Nielsen and Poulsen, {Steen Seier}",
year = "1995",
month = dec,
day = "14",
language = "English",
volume = "60",
pages = "117--24",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "2-3",

}

RIS

TY - JOUR

T1 - Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine

AU - Vinter-Jensen, Lars

AU - Smerup, Morten Holdgaard

AU - Kissmeyer-Nielsen, Peter

AU - Poulsen, Steen Seier

PY - 1995/12/14

Y1 - 1995/12/14

N2 - We examined the effects of treatment with human recombinant epidermal growth factor (EGF) on the functioning small intestine in the rat. Male Wistar rats, 7-8 weeks old, were treated with EGF administered subcutaneously in doses of 0 (n = 7) or 150 micrograms/kg/day (n = 8) for 4 weeks. The histological composition and mucosal surface area of the perfusion-fixed small intestine was quantified with stereological principles. The length of the gut remained unchanged. The amount of tissue and surface area per length of gut (median (ranges)) were increased from 117 (101-131) mg/cm and 2.6 (2.1-3.5) cm2/cm in the controls to 146 (138-152) mg/cm and 3.5 (2.5-3.8) cm2/cm for the complete small intestine (both comparisons P <0.02). The weight increase was due to mucosal growth in all parts of the intestine, whereas the surface area was only increased in proximal and middle parts. It is concluded that EGF treatment in rats increases the mucosal weight and surface area of the functioning small intestine.

AB - We examined the effects of treatment with human recombinant epidermal growth factor (EGF) on the functioning small intestine in the rat. Male Wistar rats, 7-8 weeks old, were treated with EGF administered subcutaneously in doses of 0 (n = 7) or 150 micrograms/kg/day (n = 8) for 4 weeks. The histological composition and mucosal surface area of the perfusion-fixed small intestine was quantified with stereological principles. The length of the gut remained unchanged. The amount of tissue and surface area per length of gut (median (ranges)) were increased from 117 (101-131) mg/cm and 2.6 (2.1-3.5) cm2/cm in the controls to 146 (138-152) mg/cm and 3.5 (2.5-3.8) cm2/cm for the complete small intestine (both comparisons P <0.02). The weight increase was due to mucosal growth in all parts of the intestine, whereas the surface area was only increased in proximal and middle parts. It is concluded that EGF treatment in rats increases the mucosal weight and surface area of the functioning small intestine.

KW - Animals

KW - Epidermal Growth Factor

KW - Intestinal Mucosa

KW - Intestine, Small

KW - Male

KW - Random Allocation

KW - Rats

KW - Rats, Wistar

KW - Recombinant Proteins

KW - Surface Properties

KW - Time Factors

M3 - Journal article

C2 - 8746538

VL - 60

SP - 117

EP - 124

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 2-3

ER -

ID: 47486982