Cholinesterase modulations in patients with acute bacterial meningitis
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Cholinesterase modulations in patients with acute bacterial meningitis. / Berg, Ronan M G; Ofek, Keren; Qvist, Tavs; Tofteng, Flemming; Soreq, Hermona; Møller, Kirsten.
In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 71, No. 4, 07.2011, p. 350-2.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cholinesterase modulations in patients with acute bacterial meningitis
AU - Berg, Ronan M G
AU - Ofek, Keren
AU - Qvist, Tavs
AU - Tofteng, Flemming
AU - Soreq, Hermona
AU - Møller, Kirsten
PY - 2011/7
Y1 - 2011/7
N2 - BACKGROUND: The circulating cholinesterases acetyl- and butyrylcholinesterase may be suppressed and subsequently released from the brain in acute bacterial meningitis.METHODS: We report serum activities of acetylcholinesterase and butyrylcholinesterase in paired arterial and jugular venous samples from seven patients with acute bacterial meningitis and eight healthy controls. Paraoxonase 1, which protects these enzymes from oxidative inactivation, was also measured.FINDINGS AND CONCLUSION: Acetyl- and butyrylcholinesterase activities were lower in patients, independently of changes in paraoxonase 1. Arterial and jugular venous enzyme activities were similar both in patients and controls, suggesting that no cerebral release was present.
AB - BACKGROUND: The circulating cholinesterases acetyl- and butyrylcholinesterase may be suppressed and subsequently released from the brain in acute bacterial meningitis.METHODS: We report serum activities of acetylcholinesterase and butyrylcholinesterase in paired arterial and jugular venous samples from seven patients with acute bacterial meningitis and eight healthy controls. Paraoxonase 1, which protects these enzymes from oxidative inactivation, was also measured.FINDINGS AND CONCLUSION: Acetyl- and butyrylcholinesterase activities were lower in patients, independently of changes in paraoxonase 1. Arterial and jugular venous enzyme activities were similar both in patients and controls, suggesting that no cerebral release was present.
KW - Acetylcholinesterase/blood
KW - Acute Disease
KW - Aryldialkylphosphatase/blood
KW - Biomarkers/blood
KW - Butyrylcholinesterase/blood
KW - Case-Control Studies
KW - Humans
KW - Meningitis, Bacterial/blood
KW - Prognosis
U2 - 10.3109/00365513.2011.558107
DO - 10.3109/00365513.2011.558107
M3 - Journal article
C2 - 21303225
VL - 71
SP - 350
EP - 352
JO - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement
JF - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement
SN - 0085-591X
IS - 4
ER -
ID: 236994067