Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients. / Bellinazzi, Vera R.; Cipolli, José A.; Pimenta, Marcio V.; Guimarães, Paula V.; Pio-Magalhães, José A.; Coelho-Filho, Otavio R.; Biering-Sørensen, Tor; Matos-Souza, José R.; Sposito, Andrei C.; Nadruz, Wilson.

In: Journal of Hypertension, Vol. 33, No. 10, 2015, p. 2054-2060.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bellinazzi, VR, Cipolli, JA, Pimenta, MV, Guimarães, PV, Pio-Magalhães, JA, Coelho-Filho, OR, Biering-Sørensen, T, Matos-Souza, JR, Sposito, AC & Nadruz, W 2015, 'Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients', Journal of Hypertension, vol. 33, no. 10, pp. 2054-2060. https://doi.org/10.1097/HJH.0000000000000688

APA

Bellinazzi, V. R., Cipolli, J. A., Pimenta, M. V., Guimarães, P. V., Pio-Magalhães, J. A., Coelho-Filho, O. R., Biering-Sørensen, T., Matos-Souza, J. R., Sposito, A. C., & Nadruz, W. (2015). Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients. Journal of Hypertension, 33(10), 2054-2060. https://doi.org/10.1097/HJH.0000000000000688

Vancouver

Bellinazzi VR, Cipolli JA, Pimenta MV, Guimarães PV, Pio-Magalhães JA, Coelho-Filho OR et al. Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients. Journal of Hypertension. 2015;33(10):2054-2060. https://doi.org/10.1097/HJH.0000000000000688

Author

Bellinazzi, Vera R. ; Cipolli, José A. ; Pimenta, Marcio V. ; Guimarães, Paula V. ; Pio-Magalhães, José A. ; Coelho-Filho, Otavio R. ; Biering-Sørensen, Tor ; Matos-Souza, José R. ; Sposito, Andrei C. ; Nadruz, Wilson. / Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients. In: Journal of Hypertension. 2015 ; Vol. 33, No. 10. pp. 2054-2060.

Bibtex

@article{e59f1a09c23f45efa5bb0a2155fc3a62,
title = "Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients",
abstract = "Objective: The aim of this study was to evaluate the performance of common carotid artery diameter, flow velocity and flow velocity/artery diameter ratio as predictors of major adverse cardiovascular events (MACEs) in a sample of hypertensive patients. Methods: A cohort of 403 hypertensive patients was followed up for a median of 1260 (714) days, and 27 suffered MACEs. At baseline, participants were evaluated by clinical, laboratory, echocardiographic and carotid ultrasound analysis. Results: Patients with peak-systolic flow velocity (sFV) less than the median value and systolic artery diameter (sAD) greater than the median value presented the worst clinical outcome compared to those with isolated sFV less than the median value or sAD greater than the median value, suggesting an additive effect of these two variables. Further, Kaplan-Meier analysis demonstrated worse outcome for individuals with sFV/sAD ratio less than 85.7/s (optimal cut-off point obtained by receiver-operating characteristic analysis) compared to those with higher sFV/sAD values (log-rank test: P<0.0001). In stepwise multivariable Cox-regression analyses, sFV/sAD was significantly associated with MACEs (P<0.001), whereas carotid intima-media thickness and clinically defined high cardiovascular risk did not. Furthermore, area under the receiver-operating characteristic curve for sFV/sAD was higher than that for Framingham risk score (0.77 versus 0.64; P=0.045), whereas adding sFV/sAD to the Framingham risk factors resulted in increased net reclassification improvement (P=0.041) and integrated discrimination improvement (P<0.001). Conclusions: Lower carotid sFV/sAD was associated with MACEs in hypertensive patients independent of cardiovascular prediction models and carotid intima-media thickness. These findings suggest that this index may be a promising approach to identify hypertensive subjects at increased risk for future cardiovascular events.",
keywords = "carotid, diameter, flow velocity, hypertension, intima-media thickness",
author = "Bellinazzi, {Vera R.} and Cipolli, {Jos{\'e} A.} and Pimenta, {Marcio V.} and Guimar{\~a}es, {Paula V.} and Pio-Magalh{\~a}es, {Jos{\'e} A.} and Coelho-Filho, {Otavio R.} and Tor Biering-S{\o}rensen and Matos-Souza, {Jos{\'e} R.} and Sposito, {Andrei C.} and Wilson Nadruz",
note = "Publisher Copyright: {\textcopyright} 2015 Wolters Kluwer Health, Inc.",
year = "2015",
doi = "10.1097/HJH.0000000000000688",
language = "English",
volume = "33",
pages = "2054--2060",
journal = "Journal of Hypertension, Supplement",
issn = "0952-1178",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "10",

}

RIS

TY - JOUR

T1 - Carotid flow velocity/diameter ratio is a predictor of cardiovascular events in hypertensive patients

AU - Bellinazzi, Vera R.

AU - Cipolli, José A.

AU - Pimenta, Marcio V.

AU - Guimarães, Paula V.

AU - Pio-Magalhães, José A.

AU - Coelho-Filho, Otavio R.

AU - Biering-Sørensen, Tor

AU - Matos-Souza, José R.

AU - Sposito, Andrei C.

AU - Nadruz, Wilson

N1 - Publisher Copyright: © 2015 Wolters Kluwer Health, Inc.

PY - 2015

Y1 - 2015

N2 - Objective: The aim of this study was to evaluate the performance of common carotid artery diameter, flow velocity and flow velocity/artery diameter ratio as predictors of major adverse cardiovascular events (MACEs) in a sample of hypertensive patients. Methods: A cohort of 403 hypertensive patients was followed up for a median of 1260 (714) days, and 27 suffered MACEs. At baseline, participants were evaluated by clinical, laboratory, echocardiographic and carotid ultrasound analysis. Results: Patients with peak-systolic flow velocity (sFV) less than the median value and systolic artery diameter (sAD) greater than the median value presented the worst clinical outcome compared to those with isolated sFV less than the median value or sAD greater than the median value, suggesting an additive effect of these two variables. Further, Kaplan-Meier analysis demonstrated worse outcome for individuals with sFV/sAD ratio less than 85.7/s (optimal cut-off point obtained by receiver-operating characteristic analysis) compared to those with higher sFV/sAD values (log-rank test: P<0.0001). In stepwise multivariable Cox-regression analyses, sFV/sAD was significantly associated with MACEs (P<0.001), whereas carotid intima-media thickness and clinically defined high cardiovascular risk did not. Furthermore, area under the receiver-operating characteristic curve for sFV/sAD was higher than that for Framingham risk score (0.77 versus 0.64; P=0.045), whereas adding sFV/sAD to the Framingham risk factors resulted in increased net reclassification improvement (P=0.041) and integrated discrimination improvement (P<0.001). Conclusions: Lower carotid sFV/sAD was associated with MACEs in hypertensive patients independent of cardiovascular prediction models and carotid intima-media thickness. These findings suggest that this index may be a promising approach to identify hypertensive subjects at increased risk for future cardiovascular events.

AB - Objective: The aim of this study was to evaluate the performance of common carotid artery diameter, flow velocity and flow velocity/artery diameter ratio as predictors of major adverse cardiovascular events (MACEs) in a sample of hypertensive patients. Methods: A cohort of 403 hypertensive patients was followed up for a median of 1260 (714) days, and 27 suffered MACEs. At baseline, participants were evaluated by clinical, laboratory, echocardiographic and carotid ultrasound analysis. Results: Patients with peak-systolic flow velocity (sFV) less than the median value and systolic artery diameter (sAD) greater than the median value presented the worst clinical outcome compared to those with isolated sFV less than the median value or sAD greater than the median value, suggesting an additive effect of these two variables. Further, Kaplan-Meier analysis demonstrated worse outcome for individuals with sFV/sAD ratio less than 85.7/s (optimal cut-off point obtained by receiver-operating characteristic analysis) compared to those with higher sFV/sAD values (log-rank test: P<0.0001). In stepwise multivariable Cox-regression analyses, sFV/sAD was significantly associated with MACEs (P<0.001), whereas carotid intima-media thickness and clinically defined high cardiovascular risk did not. Furthermore, area under the receiver-operating characteristic curve for sFV/sAD was higher than that for Framingham risk score (0.77 versus 0.64; P=0.045), whereas adding sFV/sAD to the Framingham risk factors resulted in increased net reclassification improvement (P=0.041) and integrated discrimination improvement (P<0.001). Conclusions: Lower carotid sFV/sAD was associated with MACEs in hypertensive patients independent of cardiovascular prediction models and carotid intima-media thickness. These findings suggest that this index may be a promising approach to identify hypertensive subjects at increased risk for future cardiovascular events.

KW - carotid

KW - diameter

KW - flow velocity

KW - hypertension

KW - intima-media thickness

UR - http://www.scopus.com/inward/record.url?scp=84960157733&partnerID=8YFLogxK

U2 - 10.1097/HJH.0000000000000688

DO - 10.1097/HJH.0000000000000688

M3 - Journal article

C2 - 26237558

AN - SCOPUS:84960157733

VL - 33

SP - 2054

EP - 2060

JO - Journal of Hypertension, Supplement

JF - Journal of Hypertension, Supplement

SN - 0952-1178

IS - 10

ER -

ID: 324131327