B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts. / Goetze, Jens Peter; Rehfeld, Jens F.; Videbaek, Regitze; Friis-Hansen, Lennart; Kastrup, Jens.

In: European Journal of Heart Failure, Vol. 7, No. 1, 01.2005, p. 69-74.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Goetze, JP, Rehfeld, JF, Videbaek, R, Friis-Hansen, L & Kastrup, J 2005, 'B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts', European Journal of Heart Failure, vol. 7, no. 1, pp. 69-74. https://doi.org/10.1016/j.ejheart.2004.04.012

APA

Goetze, J. P., Rehfeld, J. F., Videbaek, R., Friis-Hansen, L., & Kastrup, J. (2005). B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts. European Journal of Heart Failure, 7(1), 69-74. https://doi.org/10.1016/j.ejheart.2004.04.012

Vancouver

Goetze JP, Rehfeld JF, Videbaek R, Friis-Hansen L, Kastrup J. B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts. European Journal of Heart Failure. 2005 Jan;7(1):69-74. https://doi.org/10.1016/j.ejheart.2004.04.012

Author

Goetze, Jens Peter ; Rehfeld, Jens F. ; Videbaek, Regitze ; Friis-Hansen, Lennart ; Kastrup, Jens. / B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts. In: European Journal of Heart Failure. 2005 ; Vol. 7, No. 1. pp. 69-74.

Bibtex

@article{fe1100d8f1494f1d94db61e719f4690a,
title = "B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts",
abstract = "Background: Plasma concentrations of B-type natriuretic peptide (BNP-32) and its precursor (proBNP) are increased in chronic heart failure. Accordingly, BNP-32 and proBNP are both being implemented as clinical markers. Aim: To determine the molar relation of BNP-32 and proBNP in different cardiovascular regions. Methods and results: Blood samples were obtained from different cardiovascular regions during right heart catheterization in heart failure patients, and from normal subjects. Plasma BNP-32 and proBNP concentrations were measured using sequence-specific radioimmunoassays. Patients with severe left ventricular dysfunction (n=21) displayed increased peripheral plasma concentrations of both BNP-32 (four-fold, P=0.0008) and proBNP (seven-fold, P=0.0002) compared with normal subjects. Moreover, the peripheral concentrations were highly correlated with the corresponding concentrations in the coronary sinus (BNP-32: r=0.97, P<0.0001; proBNP: r=0.94, P<0.0001). Despite comparable peripheral concentrations of BNP-32 and proBNP, the BNP-32 concentration was higher than the proBNP concentration in the coronary sinus (median 126 pmol/l (21-993) vs. 103 pmol/l (16-691), P=0.035). Conclusions: The BNP-32 and proBNP concentrations are closely related in venous cardiac blood. The findings suggest an overall constitutive secretion of processed proBNP, i.e. an N-terminal precursor fragment and BNP-32, in chronic heart failure.",
keywords = "B-type natriuretic peptide, Cardiac secretion, Heart failure, Natriuretic peptide, proBNP",
author = "Goetze, {Jens Peter} and Rehfeld, {Jens F.} and Regitze Videbaek and Lennart Friis-Hansen and Jens Kastrup",
year = "2005",
month = jan,
doi = "10.1016/j.ejheart.2004.04.012",
language = "English",
volume = "7",
pages = "69--74",
journal = "European Journal of Heart Failure",
issn = "1567-4215",
publisher = "JohnWiley & Sons Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - B-type natriuretic peptide and its precursor in cardiac venous blood from failing hearts

AU - Goetze, Jens Peter

AU - Rehfeld, Jens F.

AU - Videbaek, Regitze

AU - Friis-Hansen, Lennart

AU - Kastrup, Jens

PY - 2005/1

Y1 - 2005/1

N2 - Background: Plasma concentrations of B-type natriuretic peptide (BNP-32) and its precursor (proBNP) are increased in chronic heart failure. Accordingly, BNP-32 and proBNP are both being implemented as clinical markers. Aim: To determine the molar relation of BNP-32 and proBNP in different cardiovascular regions. Methods and results: Blood samples were obtained from different cardiovascular regions during right heart catheterization in heart failure patients, and from normal subjects. Plasma BNP-32 and proBNP concentrations were measured using sequence-specific radioimmunoassays. Patients with severe left ventricular dysfunction (n=21) displayed increased peripheral plasma concentrations of both BNP-32 (four-fold, P=0.0008) and proBNP (seven-fold, P=0.0002) compared with normal subjects. Moreover, the peripheral concentrations were highly correlated with the corresponding concentrations in the coronary sinus (BNP-32: r=0.97, P<0.0001; proBNP: r=0.94, P<0.0001). Despite comparable peripheral concentrations of BNP-32 and proBNP, the BNP-32 concentration was higher than the proBNP concentration in the coronary sinus (median 126 pmol/l (21-993) vs. 103 pmol/l (16-691), P=0.035). Conclusions: The BNP-32 and proBNP concentrations are closely related in venous cardiac blood. The findings suggest an overall constitutive secretion of processed proBNP, i.e. an N-terminal precursor fragment and BNP-32, in chronic heart failure.

AB - Background: Plasma concentrations of B-type natriuretic peptide (BNP-32) and its precursor (proBNP) are increased in chronic heart failure. Accordingly, BNP-32 and proBNP are both being implemented as clinical markers. Aim: To determine the molar relation of BNP-32 and proBNP in different cardiovascular regions. Methods and results: Blood samples were obtained from different cardiovascular regions during right heart catheterization in heart failure patients, and from normal subjects. Plasma BNP-32 and proBNP concentrations were measured using sequence-specific radioimmunoassays. Patients with severe left ventricular dysfunction (n=21) displayed increased peripheral plasma concentrations of both BNP-32 (four-fold, P=0.0008) and proBNP (seven-fold, P=0.0002) compared with normal subjects. Moreover, the peripheral concentrations were highly correlated with the corresponding concentrations in the coronary sinus (BNP-32: r=0.97, P<0.0001; proBNP: r=0.94, P<0.0001). Despite comparable peripheral concentrations of BNP-32 and proBNP, the BNP-32 concentration was higher than the proBNP concentration in the coronary sinus (median 126 pmol/l (21-993) vs. 103 pmol/l (16-691), P=0.035). Conclusions: The BNP-32 and proBNP concentrations are closely related in venous cardiac blood. The findings suggest an overall constitutive secretion of processed proBNP, i.e. an N-terminal precursor fragment and BNP-32, in chronic heart failure.

KW - B-type natriuretic peptide

KW - Cardiac secretion

KW - Heart failure

KW - Natriuretic peptide

KW - proBNP

UR - http://www.scopus.com/inward/record.url?scp=11844288336&partnerID=8YFLogxK

U2 - 10.1016/j.ejheart.2004.04.012

DO - 10.1016/j.ejheart.2004.04.012

M3 - Journal article

C2 - 15642534

AN - SCOPUS:11844288336

VL - 7

SP - 69

EP - 74

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1567-4215

IS - 1

ER -

ID: 310766766