An Uncommon Case of Pediatric Esthesioneuroblastoma Presenting as SIADH: 18F-FDG PET/CT in Staging and Post-Therapeutic Assessment
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An Uncommon Case of Pediatric Esthesioneuroblastoma Presenting as SIADH : 18F-FDG PET/CT in Staging and Post-Therapeutic Assessment. / Fosbøl, Marie Øbro; Bilde, Anders; Friborg, Jeppe; von Benzon, Eric; Kjær, Andreas; von Buchwald, Christian; Borgwardt, Lise.
In: Diagnostics, Vol. 8, No. 1, 8, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - An Uncommon Case of Pediatric Esthesioneuroblastoma Presenting as SIADH
T2 - 18F-FDG PET/CT in Staging and Post-Therapeutic Assessment
AU - Fosbøl, Marie Øbro
AU - Bilde, Anders
AU - Friborg, Jeppe
AU - von Benzon, Eric
AU - Kjær, Andreas
AU - von Buchwald, Christian
AU - Borgwardt, Lise
PY - 2018
Y1 - 2018
N2 - Esthesioneuroblastoma (ENB) is an uncommon neuroendocrine tumor originating from the olfactory neuroepithelium and accounts for 3-6% of all intranasal tumors [¹]. ENBs can be locally aggressive and cause invasion and destruction of surrounding structures. Histological grading and clinical stage at presentation are highly predictive of survival and especially presence of lymph node and distant metastases are determining prognostic factors [²,³,⁴,⁵]. Thus, reliable imaging is essential in these patients. Conventional imaging modalities for staging ENB are magnetic resonance imaging (MRI) and computed tomography (CT). However, fluorine-18 fluoro-2-deoxy-d-glucose positron emission tomography/CT (18F-FDG PET/CT) has been reported as a valuable adjunct and was found to upstage 36% of ENB patients compared to conventional imaging [6]. We present a case demonstrating the diagnostic work-up and follow-up with 18F-FDG PET/CT in a young patient with ENB with a highly atypical clinical presentation.
AB - Esthesioneuroblastoma (ENB) is an uncommon neuroendocrine tumor originating from the olfactory neuroepithelium and accounts for 3-6% of all intranasal tumors [¹]. ENBs can be locally aggressive and cause invasion and destruction of surrounding structures. Histological grading and clinical stage at presentation are highly predictive of survival and especially presence of lymph node and distant metastases are determining prognostic factors [²,³,⁴,⁵]. Thus, reliable imaging is essential in these patients. Conventional imaging modalities for staging ENB are magnetic resonance imaging (MRI) and computed tomography (CT). However, fluorine-18 fluoro-2-deoxy-d-glucose positron emission tomography/CT (18F-FDG PET/CT) has been reported as a valuable adjunct and was found to upstage 36% of ENB patients compared to conventional imaging [6]. We present a case demonstrating the diagnostic work-up and follow-up with 18F-FDG PET/CT in a young patient with ENB with a highly atypical clinical presentation.
U2 - 10.3390/diagnostics8010008
DO - 10.3390/diagnostics8010008
M3 - Journal article
C2 - 29342907
VL - 8
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 1
M1 - 8
ER -
ID: 213961605