a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg
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a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg. / Keller, David M; Sander, Mikael; Stallknecht, Bente Merete; Crandall, Craig G.
In: Journal of Physiology, Vol. 588, No. Pt 19, 01.10.2010, p. 3799-808.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg
AU - Keller, David M
AU - Sander, Mikael
AU - Stallknecht, Bente Merete
AU - Crandall, Craig G
PY - 2010/10/1
Y1 - 2010/10/1
N2 - This study tested the hypothesis that passive leg heating attenuates a-adrenergic vasoconstriction within that limb. Femoral blood flow (FBF, femoral artery ultrasound Doppler) and femoral vascular conductance (FVC, FBF/mean arterial blood pressure), as well as calf muscle blood flow (CalfBF, ¹³³xenon) and calf vascular conductance (CalfVC) were measured during intra-arterial infusion of an a1-adrenoreceptor agonist, phenylephrine (PE, 0.025 to 0.8 µg kg¿1 min¿1) and an a2-adrenoreceptor agonist, BHT-933 (1.0 to 10 µg kg¿1 min¿1) during normothermia and passive leg heating (water-perfused pant leg). Passive leg heating (~46¿C water temperature) increased FVC from 4.5 ± 0.5 to 11.9 ± 1.3 ml min¿1 mmHg¿1 (P <0.001). Interestingly, CalfBF (1.8±0.2 vs. 2.8±0.3mlmin¿1 (100 g)¿1) and CalfVC (2.0±0.3 vs. 3.9±0.5mlmin¿1 (100 g)¿1 mmHg¿1 ×100) were also increased by this perturbation (P
AB - This study tested the hypothesis that passive leg heating attenuates a-adrenergic vasoconstriction within that limb. Femoral blood flow (FBF, femoral artery ultrasound Doppler) and femoral vascular conductance (FVC, FBF/mean arterial blood pressure), as well as calf muscle blood flow (CalfBF, ¹³³xenon) and calf vascular conductance (CalfVC) were measured during intra-arterial infusion of an a1-adrenoreceptor agonist, phenylephrine (PE, 0.025 to 0.8 µg kg¿1 min¿1) and an a2-adrenoreceptor agonist, BHT-933 (1.0 to 10 µg kg¿1 min¿1) during normothermia and passive leg heating (water-perfused pant leg). Passive leg heating (~46¿C water temperature) increased FVC from 4.5 ± 0.5 to 11.9 ± 1.3 ml min¿1 mmHg¿1 (P <0.001). Interestingly, CalfBF (1.8±0.2 vs. 2.8±0.3mlmin¿1 (100 g)¿1) and CalfVC (2.0±0.3 vs. 3.9±0.5mlmin¿1 (100 g)¿1 mmHg¿1 ×100) were also increased by this perturbation (P
KW - Adrenergic alpha-1 Receptor Agonists
KW - Adrenergic alpha-2 Receptor Antagonists
KW - Adrenergic alpha-Agonists
KW - Adult
KW - Azepines
KW - Blood Pressure
KW - Body Temperature
KW - Dose-Response Relationship, Drug
KW - Hot Temperature
KW - Humans
KW - Leg
KW - Male
KW - Muscle, Skeletal
KW - Phenylephrine
KW - Receptors, Adrenergic, alpha
KW - Regional Blood Flow
KW - Ultrasonography, Doppler
KW - Vasoconstriction
KW - Xenon Radioisotopes
KW - Young Adult
U2 - 10.1113/jphysiol.2010.194506
DO - 10.1113/jphysiol.2010.194506
M3 - Journal article
C2 - 20693291
VL - 588
SP - 3799
EP - 3808
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - Pt 19
ER -
ID: 33941195