A rat model with an isolated bladder in situ
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A rat model with an isolated bladder in situ. / Thulesen, J; Olsen, P S; Grevstad, J U; Poulsen, Steen Seier.
In: Surgery Today, Vol. 27, No. 11, 1997, p. 1089-1092.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A rat model with an isolated bladder in situ
AU - Thulesen, J
AU - Olsen, P S
AU - Grevstad, J U
AU - Poulsen, Steen Seier
PY - 1997
Y1 - 1997
N2 - This paper describes our method for producing a rat model with an isolated bladder in situ in which the bladder makes no contact with urine. First, the right kidney was removed, then an external catheter was placed in the right ureter for bladder infusions, and next the left ureter was anatomosed to the proximal part of the descending colon. The animals were treated with antibiotics, and saline was infused daily into the bladder in order to prevent atrophy. This in situ model is considered to be useful in studies investigating the influence of specific compounds, such as carcinogens, on the bladder and its urothelium.
AB - This paper describes our method for producing a rat model with an isolated bladder in situ in which the bladder makes no contact with urine. First, the right kidney was removed, then an external catheter was placed in the right ureter for bladder infusions, and next the left ureter was anatomosed to the proximal part of the descending colon. The animals were treated with antibiotics, and saline was infused daily into the bladder in order to prevent atrophy. This in situ model is considered to be useful in studies investigating the influence of specific compounds, such as carcinogens, on the bladder and its urothelium.
KW - Anastomosis, Surgical
KW - Animals
KW - Colon
KW - Disease Models, Animal
KW - Male
KW - Rats
KW - Rats, Wistar
KW - Ureter
KW - Urinary Bladder
KW - Urography
M3 - Journal article
C2 - 9413068
VL - 27
SP - 1089
EP - 1092
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 11
ER -
ID: 226720