A biphasic response of urinary prostaglandin E2 excretion to water deprivation in conscious diabetes insipidus Brattleboro rats.
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A biphasic response of urinary prostaglandin E2 excretion to water deprivation in conscious diabetes insipidus Brattleboro rats. / Kanters, J K; Holstein-Rathlou, N H; Christensen, P; Leyssac, P P.
In: Prostaglandins, Leukotrienes & Essential Fatty Acids, Vol. 35, No. 2, 1989, p. 85-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A biphasic response of urinary prostaglandin E2 excretion to water deprivation in conscious diabetes insipidus Brattleboro rats.
AU - Kanters, J K
AU - Holstein-Rathlou, N H
AU - Christensen, P
AU - Leyssac, P P
N1 - Keywords: Animals; Diabetes Insipidus; Dinoprostone; Male; Rats; Rats, Brattleboro; Time Factors; Urodynamics; Vasopressins; Water Deprivation
PY - 1989
Y1 - 1989
N2 - The effects of water deprivation on the urinary excretion rate of prostaglandin E2 (PGE2) were examined in conscious Brattleboro rats. In order to study the time course of the changes in the PGE2 excretory rate, urine was collected in 6 periods, Control: 0-1 hour (h.). 1: 3-4.5 h., 8-10 h., III: 12-15 h., IV: 24-28 h. and V: 32-36 h. after removal of water and food. It was found that the PGE2 excretion rate changed in a biphasic pattern. During the first 2 experimental periods it increased. Thereafter it decreased towards the control value. There was an increase in PGE2 excretion with urinary flows down to 3 microliter/(min*100 g b. wt). At further reductions in urinary flow rate, PG excretion decreased towards basal levels.
AB - The effects of water deprivation on the urinary excretion rate of prostaglandin E2 (PGE2) were examined in conscious Brattleboro rats. In order to study the time course of the changes in the PGE2 excretory rate, urine was collected in 6 periods, Control: 0-1 hour (h.). 1: 3-4.5 h., 8-10 h., III: 12-15 h., IV: 24-28 h. and V: 32-36 h. after removal of water and food. It was found that the PGE2 excretion rate changed in a biphasic pattern. During the first 2 experimental periods it increased. Thereafter it decreased towards the control value. There was an increase in PGE2 excretion with urinary flows down to 3 microliter/(min*100 g b. wt). At further reductions in urinary flow rate, PG excretion decreased towards basal levels.
M3 - Journal article
C2 - 2717654
VL - 35
SP - 85
EP - 89
JO - Prostaglandins, Leukotrienes & Essential Fatty Acids
JF - Prostaglandins, Leukotrienes & Essential Fatty Acids
SN - 0952-3278
IS - 2
ER -
ID: 8440060