Søren-Peter Olesen
Professor
Molecular Cardiology and Membrane Proteins
Blegdamsvej 3, 2200 København N.
- Published
Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats
Jepps, Thomas Andrew Qvistgaard, Olesen, Søren-Peter, Greenwood, I. A. & Dalsgaard, T., May 2016, In: British Journal of Pharmacology. 173, 9, p. 1478-1490 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mutations in sodium channel {beta}-subunit SCN3B are associated with early-onset lone atrial fibrillation
Olesen, M. S., Jespersen, Thomas, Nielsen, J. B., Liang, B., Møller, D. V., Hedley, P., Christiansen, M., Varro, A., Olesen, Søren-Peter, Haunsø, Stig, Schmitt, Nicole & Svendsen, Jesper Hastrup, 2011, In: Cardiovascular Research. 89, 4, p. 786-793 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.
Nielsen, N. H., Winkel, B. G., Kanters, Jørgen K., Schmitt, Nicole, Hofman-Bang, J., Jensen, H. S., Bentzen, Bo Hjorth, Sigurd, B., Larsen, Lars Allan, Andersen, P. S., Kjeldsen, K., Grunnet, Morten, Christiansen, M., Olesen, Søren-Peter & Haunsø, Stig, 2007, In: Biochemical and Biophysical Research Communications. 354, 3, p. 776-82 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Myocardial structural, contractile and electrophysiological changes in the guinea-pig heart failure model induced by chronic sympathetic activation
Soltysinska, E., Osadchiy, O. & Olesen, Søren-Peter, 2011, In: Experimental Physiology. 96, 7, p. 647-63 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions
Nausch, B., Rode, F., Jørgensen, S., Nardi, A., Korsgaard, M. P. G., Hougaard, C., Bonev, A. D., Brown, W. D., Dyhring, T., Strøbæk, D., Olesen, Søren-Peter, Christophersen, P., Grunnet, M., Nelson, M. T. & Rønn, L. C. B., Sep 2014, In: Journal of Pharmacology and Experimental Therapeutics. 350, 3, p. 520-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1.
Korolkova, Y. V., Bocharov, E. V., Angelo, K., Maslennikov, I. V., Grinenko, O. V., Lipkin, A. V., Nosyreva, E. D., Pluzhnikov, K. A., Olesen, Søren-Peter, Arseniev, A. S. & Grishin, E. V., 2002, In: Journal of Biological Chemistry. 277, 45, p. 43104-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Non-invasive detection of animal nerve impulses with an atomic magnetometer operating near quantum limited sensitivity
Jensen, K., Budvytyte, R., Thomas, Rodrigo A., Wang, T., Fuchs, A. M., Balabas, M. V., Vasilakis, G., Mosgaard, L. D., Stærkind, Hans, Müller, Jörg Helge, Heimburg, Thomas Rainer, Olesen, Søren-Peter & Polzik, Eugene Simon, 15 Jul 2016, In: Scientific Reports. 6, 29638.Research output: Contribution to journal › Journal article › Research › peer-review
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Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality
Ghouse, Jonas, Have, C. T., Skov, M. W., Andreasen, Laura Korsholm, Ahlberg, G., Nielsen, J. B., Skaaby, T., Olesen, Søren-Peter, Grarup, Niels, Linneberg, Allan René, Pedersen, Oluf Borbye, drb459, drb459, Haunsø, Stig, Svendsen, Jesper Hastrup, Hansen, Torben, Kanters, Jørgen K. & Olesen, Morten Steen Salling, May 2017, In: Genetics In Medicine. 19, 5, p. 521-528 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders
Jepps, Thomas Andrew Qvistgaard, Olesen, Søren-Peter & Greenwood, I. A., 2013, In: British Journal of Pharmacology. 168, 1, p. 19-27 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart.
Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Journal of Pharmacology and Experimental Therapeutics. 321, 3, p. 996-1002 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological characterization of small-conductance Ca(2+)-activated channels stably expressed in HEK 293 cells
Strobaek, D., Jørgensen, T. D., Christophersen, P., Ahring, P. K. & Olesen, Søren-Peter, 2000, In: British Journal of Pharmacology. 129(5), p. 991-999Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological investigation of the role of ion channels in salivary secretion.
Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Rasmussen, Hanne Borger, Olesen, Søren-Peter & Jorgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 1, p. 78-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphatidylinositol-bisphosphate regulates intercellular coupling in cardiac myocytes
Hofgaard, J. P., Banach, K., Mollerup, S., Jørgensen, H. K., Olesen, Søren-Peter, von Holstein-Rathlou, Niels-Henrik & Nielsen, Morten Schak, 2008, In: Pflügers Archiv: European Journal of Physiology. 457, 2, p. 303-13 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physiological consequences of transient outward K(+) current activation during heart failure in the canine left ventricle
Cordeiro, J. M., Callø, Kirstine, Moise, N. S., Kornreich, B., Giannandrea, D., Di Diego, J. M., Olesen, Søren-Peter & Antzelevitch, C., 2012, In: Journal of Molecular and Cellular Cardiology. 52, 6, p. 1291-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preservation of cardiac function by prolonged action potentials in mice deficient of KChIP2
Grubb, Søren, Aistrup, G. L., Koivumäki, J. T., Speerschneider, T., Gottlieb, Lisa Amalie, Mutsaers, N. A. M., Olesen, Søren-Peter, Callø, Kirstine & Thomsen, Morten Bækgaard, 1 Aug 2015, In: American Journal of Physiology: Heart and Circulatory Physiology. 309, 3, p. H481-H489 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking
Andersen, M. N., Hefting, L. L., Steffensen, Annette Buur, Schmitt, Nicole, Olesen, Søren-Peter, Olsen, Jesper Velgaard, Lundby, Alicia & Rasmussen, Hanne Borger, 15 Nov 2015, In: American Journal of Physiology: Cell Physiology. 309, 10, p. C693-C706 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation
Ahlberg, G., Refsgaard, L., Lundegaard, Pia Rengtved, Andreasen, Laura Korsholm, Ranthe, M. F., Linscheid, N., Nielsen, J. B., Melbye, M., Haunsø, Stig, Sajadieh, Ahmad, Camp, L., Olesen, Søren-Peter, Rasmussen, Simon, Lundby, Alicia, Ellinor, P. T., Holst, A. G., Svendsen, Jesper Hastrup & Olesen, Morten Steen Salling, 2018, In: Nature Communications. 9, 1, 11 p., 4316.Research output: Contribution to journal › Journal article › Research › peer-review
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Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired ß-adrenoceptor-mediated relaxation of renal arteries in hypertension
Chadha, P. S., Zunke, F., Zhu, H., Davis, A. J., Jepps, Thomas Andrew Qvistgaard, Olesen, Søren-Peter, Cole, W. C., Moffatt, J. D. & Greenwood, I., 2012, In: Hypertension. 59, 4, p. 877-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of cloned, Ca2+-activated K+ channels by cell volume changes.
Grunnet, Morten, MacAulay, Nanna, Jorgensen, N. K., Jensen, S., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Pflügers Archiv: European Journal of Physiology. 444, 1-2, p. 167-77 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment.
Rasmussen, Hanne Borger, Frøkjær-Jensen, Christian, Jensen, C. S., Jensen, H. S., Jørgensen, N. K., Misonou, H., Trimmer, J. S., Olesen, Søren-Peter & Schmitt, Nicole, 2007, In: Journal of Cell Science. 120, Pt 6, p. 953-63 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Single-copy insertion of transgenes in Caenorhabditis elegans.
Frøkjær-Jensen, Christian, Davis, M. W., Hopkins, C. E., Newman, B. J., Thummel, J. M., Olesen, Søren-Peter, Grunnet, Morten & Jorgensen, E. M., 2008, In: Nature Genetics. 40, 11, p. 1375-83 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Specific Sorting and Post-Golgi trafficking of Dendritic Potassium Channels in Living Neurons
Jensen, C. S., Watanabe, S., Rasmussen, Hanne Borger, Schmitt, Nicole, Olesen, Søren-Peter, Frost, N. A., Blanpied, T. A. & Misonou, H., 25 Feb 2014, In: The Journal of Biological Chemistry. 289, p. 10566-10581 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart.
Rasmussen, Hanne Borger, Møller, Morten, Knaus, H., Jensen, B. S., Olesen, Søren-Peter & Jørgensen, N. K., 2003, In: American Journal of Physiology: Heart and Circulatory Physiology. 286, 4, p. H1300-9Research output: Contribution to journal › Journal article › Research › peer-review
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Subcellular localization of the delayed rectifier potassium channel KCNQ1 and ERG1 in rat heart
Rasmussen, H. B., Møller, M., Knaus, H. G., Jensen, B. S., Olesen, Søren-Peter & Jørgensen, N. K., 2004, In: American Journal of Physiology: Heart and Circulatory Physiology. 286, p. H1300-H1309Research output: Contribution to journal › Journal article › Research › peer-review
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Subtype-specific, bi-component inhibition of SK channels by low internal pH.
Peitersen, T., Jespersen, Thomas, Jorgensen, N. K., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 3, p. 943-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo
Bentzen, Bo Hjorth, Andersen, R. W., Olesen, Søren-Peter, Grunnet, Morten & Nardi, A., 2009, In: NAUNYN-SCHMIEDEBERGS ARCHIV FUR EXPERIMENTELLE PATHOLOGIE UND PHARMAKOLOGIE.Research output: Contribution to journal › Journal article › Research › peer-review
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TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension
Askew Page, H. R., Dalsgaard, T., Baldwin, S. N., Jepps, Thomas Andrew Qvistgaard, Povstyan, O., Olesen, Søren-Peter & Greenwood, I. A., Jun 2019, In: British Journal of Pharmacology. 176, 11, p. 1635-1648Research output: Contribution to journal › Journal article › Research › peer-review
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Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
Diness, Jonas Goldin, Skibsbye, L., Simó-Vicens, R., Louro Larupa dos Santos, J., Lundegaard, Pia Rengtved, Citerni, C., Sauter, D. R. P., Bomholtz, Sofia Hammami, Svendsen, Jesper Hastrup, Olesen, Søren-Peter, Sørensen, U. S., Jespersen, Thomas, Grunnet, Morten & Bentzen, Bo Hjorth, 10 Oct 2017, In: Circulation: Arrhythmia and Electrophysiology. 10, 19 p., e005125.Research output: Contribution to journal › Journal article › Research › peer-review
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The Ca2+-activated K+ channel of intermediate-conductance: A molecular target for novel treatments?
Jensen Skanning, B., Strøbaek, D., Olesen, Søren-Peter & Christophersen, P., 2001, In: Current Drug Targets. 2, p. 401-422Research output: Contribution to journal › Journal article › Research › peer-review
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The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.
Jespersen, Thomas, Membrez, M., Nicolas, C. S., Pitard, B., Staub, O., Olesen, Søren-Peter, Baró, I. & Abriel, H., 2007, In: Cardiovascular Research. 74, 1, p. 64-74 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The KCNQ1 potassium channel: from gene to physiological function.
Jespersen, Thomas, Grunnet, Morten & Olesen, Søren-Peter, 2005, In: Physiology. 20, p. 408-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes.
Jensen, H. S., Callø, Kirstine, Jespersen, Thomas, Jensen, B. S. & Olesen, Søren-Peter, 2005, In: Brain Research. 139, 1, p. 52-62 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Phenotype Characteristics of Type-13 Long QT Syndrome with mutation in KCNJ5 (Kir3.4-G387R)
Wang, F., Liu, J., Hong, L., Liang, B., Graff, C., Yang, Y., Christiansen, M., Olesen, Søren-Peter, Zhang, L. & Kanters, Jørgen K., Oct 2013, In: Heart rhythm : the official journal of the Heart Rhythm Society. 10, 10, p. 1500-1506 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Bentzen, Bo Hjorth, Schmitt, Nicole, Callø, Kirstine, Dalby Brown, W., Grunnet, Morten & Olesen, Søren-Peter, 2006, In: Neuropharmacology. 51, 6, p. 1068-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The case of BK channel openers
Nardi, A., Calderone, V. & Olesen, Søren-Peter, 2006, In: Letters in Drug Design and Discovery. 3, p. 210-218Research output: Contribution to journal › Journal article › Research
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The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?
Jespersen, Thomas, Grunnet, Morten, Rasmussen, Hanne Borger, Jørgensen, N. B., Jensen, H., Angelo, K., Olesen, Søren-Peter & Klærke, Dan Arne, 2006, In: Biochemical and Biophysical Research Communications. 341, 4, p. 979-88 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The genetic component of Brugada syndrome
Nielsen, M. W., Holst, A. G., Olesen, Søren-Peter & Olesen, Morten Steen Salling, 2013, In: Frontiers in Physiology. 4, p. 179Research output: Contribution to journal › Journal article › Research › peer-review
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The genetic component of Brugada syndrome
Nielsen, M. W., Holst, A. G., Olesen, Søren-Peter & Olesen, Morten Steen Salling, 2013, In: Frontiers in Physiology. 4, p. 179Research output: Contribution to journal › Journal article › Research › peer-review
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The role og K+ and C1- channels in salivary secretion
Stummann, T. C., Poulsen, J. H., Hay-Schmidt, Anders, Grunnet, Morten, Klærke, Dan Arne, Olesen, Søren-Peter & Jørgensen, N. K., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, p. 78-87Research output: Contribution to journal › Journal article › Research › peer-review
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The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.
Bentzen, Bo Hjorth, Nardi, A., Callø, Kirstine, Madsen, L. S., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Molecular Pharmacology. 72, 4, p. 1033-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size
Christensen, A. H., Chatelain, F. C., Huttner, I. G., Olesen, Morten Steen Salling, Soka, M., Feliciangeli, S., Horvat, C., Santiago, C. F., Vandenberg, J. I., Schmitt, Nicole, Olesen, Søren-Peter, Lesage, F. & Fatkin, D., Aug 2016, In: Journal of Molecular and Cellular Cardiology. 97, p. 24-35 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tissue-specific effects of acetylcholine in the canine heart
Callø, Kirstine, Goodrow, R., Olesen, Søren-Peter, Antzelevitch, C. & Cordeiro, J. M., 2013, In: A J P: Heart and Circulatory Physiology (Online). 305, p. H66-H75 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway
Jensen, C. S., Watanabe, S., Stas, J. I., Klaphaak, J., Yamane, A., Schmitt, Nicole, Olesen, Søren-Peter, Trimmer, J. S., Rasmussen, Hanne Borger & Misonou, H., 29 Nov 2017, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, 48, p. 11523-11536 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Trafficking of the IKs -Complex in MDCK Cells: Site of Subunit Assembly and Determinants of Polarized Localization
David, J., Andersen, M. N., Olesen, Søren-Peter, Rasmussen, Hanne Borger & Schmitt, Nicole, Apr 2013, In: Traffic. 14, 4, p. 399-411 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts
Soltysinska, E., Olesen, Søren-Peter, Christ, T., Wettwer, E., Varró, A., Grunnet, Morten & Jespersen, Thomas, 2009, In: Pflügers Archiv: European Journal of Physiology. 459, 1, p. 11-23 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unique binding site on the molecular scaffold of scorpion toxin BeKm-1 provides selectivity for HERG potassium channels
Korolkova, Y. V., Bocharov, E. V., Pedersen, K. A., Maslennikov, I. V., Grinenko, O. V., Lipkin, A. V., Nosireva, E. D., Pluzhnikov, K. A., Olesen, Søren-Peter, Arseniev, A. S. & Grishin, E. V., 2002, In: Journal of Biological Chemistry. 277, p. 43104-43109Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production
Bang, L., Nielsen-Kudsk, J. E., Gruhn, N., Theilgaard, S. A., Olesen, Søren-Peter & Aldershvile, J., 1999, In: Scandinavian Cardiovascular Journal. 33, p. 71-78Research output: Contribution to journal › Journal article › Research › peer-review
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Ventricular repolarization time, location of pacing stimulus and current pulse amplitude conspire to determine arrhythmogenicity in mice
Speerschneider, T., Grubb, Søren, Olesen, Søren-Peter, Callø, Kirstine & Thomsen, Morten Bækgaard, 9 Feb 2017, In: Acta Physiologica. 219, 3, p. 662-670 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ventricular tachycardia in an Brugada syndrome patient caused by novel deletion mutation in SCN5A
Tfelt-Hansen, Jacob, Jespersen, T., Hofman-Bang, J., Rasmussen, H., Cedergreen, P. K., Skovby, F., Abriel, H., Svendsen, J., Olesen, Søren-Peter & Christiansen & Haunso, S., 2009, In: Canadian Journal of Cardiology. 25, 3Research output: Contribution to journal › Journal article › Research › peer-review
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Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation
Olesen, Morten Steen Salling, Andreasen, Laura Korsholm, Jabbari, J., Refsgaard, L., Haunsø, Stig, Olesen, Søren-Peter, Nielsen, J. B., Schmitt, Nicole & Svendsen, Jesper Hastrup, Feb 2014, In: Heart Rhythm. 11, 2, p. 246-251 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352.
Schrøder, R. L., Strøbaek, D., Olesen, Søren-Peter & Christophersen, P., 2003, In: Pflügers Archiv: European Journal of Physiology. 446, 5, p. 607-16 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.
Grunnet, Morten, Olesen, Søren-Peter, Klærke, Dan Arne & Jespersen, Thomas, 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts
Skarsfeldt, M. A., Jepps, Thomas Andrew Qvistgaard, Bomholtz, Sofia Hammami, Abildgaard, L., Sørensen, U. S., Gregers, E., Svendsen, Jesper Hastrup, Diness, J. G., Grunnet, M., Schmitt, Nicole, Olesen, Søren-Peter & Bentzen, Bo Hjorth, Apr 2016, In: Pfluegers Archiv. 468, 4, p. 643-654 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13436
Most downloads
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1433
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Tissue-specific effects of acetylcholine in the canine heart
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
495
downloads
Non-invasive detection of animal nerve impulses with an atomic magnetometer operating near quantum limited sensitivity
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
346
downloads
Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
Research output: Contribution to journal › Journal article › Research › peer-review
Published