Signe Mathiasen

Signe Mathiasen

Assistant Professor, Tenure Track Assistant Professor

Member of:

    1. 2024
    2. Accepted/In press

      Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

      Kizilkaya, H. S., Sørensen, K. V., Madsen, J. S., Lindquist, P., Douros, J. D., Bork-Jensen, J., Berghella, A., Gerlach, P. A., Gasbjerg, L. S., Mokrosiński, J., Mowery, S. A., Knerr, P. J., Finan, B., Campbell, J. E., D’Alessio, D. A., Perez-Tilve, D., Faas, F., Mathiasen, S., Rungby, J., Sørensen, H. T. & 15 others, Vaag, A., Nielsen, J. S., Holm, Jens-Christian, Lauenborg, J., Damm, Peter, Pedersen, Oluf Borbye, Linneberg, Allan René, Hartmann, Bolette, Holst, Jens Juul, Hansen, Torben, Wright, S. C., Lauschke, V. M., Grarup, N., Hauser, Alexander Sebastian & Rosenkilde, Mette, 2024, (Accepted/In press) In: Nature Metabolism.

      Research output: Contribution to journalLetterResearchpeer-review

    3. 2023
    4. Published

      Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10th adhesion GPCR workshop in Copenhagen, 2022

      Rosenkilde, Mette & Mathiasen, Signe, 2023, In: Basic & clinical pharmacology & toxicology. 133, 4, p. 281-284

      Research output: Contribution to journalEditorialResearchpeer-review

    5. Published

      Re-routing GPR56 signalling using Gα12/13 G protein chimeras

      Faas, Felix, Nørskov, Amalie, Holst, Peter Johannes, Andersson, A. M., Qvortrup, K., Mathiasen, Signe & Rosenkilde, Mette, 2023, In: Basic and Clinical Pharmacology and Toxicology. 133, 4, p. 378-389

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. 2021
    7. Single-molecule FRET imaging of GPCR dimers in living cells

      Asher, W. B., Geggier, P., Holsey, M. D., Gilmore, G. T., Pati, A. K., Meszaros, J., Terry, D. S., Mathiasen, Signe, Kaliszewski, M. J., McCauley, M. D., Govindaraju, A., Zhou, Z., Harikumar, K. G., Jaqaman, K., Miller, L. J., Smith, A. W., Blanchard, S. C. & Javitch, J. A., 2021, In: Nature Methods. 18, 4, p. 397-405 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. 2020
    9. G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

      Mathiasen, Signe, Palmisano, T., Perry, N. A., Stoveken, H. M., Vizurraga, A., McEwen, D. P., Okashah, N., Langenhan, T., Inoue, A., Lambert, N. A., Tall, G. G. & Javitch, J. A., Dec 2020, In: Nature Chemical Biology. 16, 12, p. 1343–1350

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Agonist-induced formation of unproductive receptor-G12 complexes

      Okashah, N., Wright, S. C., Kawakami, K., Mathiasen, Signe, Zhou, J., Lu, S., Javitch, J. A., Inoue, A., Bouvier, M. & Lambert, N. A., 1 Sep 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 35, p. 21723-21730 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter

      Guthrie, D. A., Klein Herenbrink, Carmen, Lycas, M. D., Ku, T., Bonifazi, A., Devree, B. T., Mathiasen, Signe, Javitch, J. A., Grimm, J. B., Lavis, L., Gether, Ulrik & Newman, A. H., 2020, In: ACS Chemical Neuroscience. 11, 20, p. 3288-3300 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. 2018
    13. Published

      Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs

      Walsh, S. M., Mathiasen, Signe, Christensen, S. M., Fay, J. F., King, C., Provasi, D., Borrero, E., Rasmussen, Søren Gøgsig Faarup, Fung, J. J., Filizola, M., Hristova, K., Kobilka, B., Farrens, D. L. & Stamou, Dimitrios, 2018, In: Biophysical Journal. 115, 2, p. 300-312 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. 2017
    15. Published

      Extreme vetting of dopamine receptor oligomerization

      Asher, W. B., Mathiasen, Signe, Holsey, M. D., Grinnell, S. G., Lambert, N. A. & Javitch, J. A., 2017, Receptors. Humana Press, p. 99-127 29 p. (Receptors, Vol. 33).

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    16. Published

      Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

      Gregorio, G. G., Masureel, M., Hilger, D., Terry, D. S., Juette, M., Zhao, H., Zhou, Z., Perez-Aguilar, J. M., Hauge, M., Mathiasen, Signe, Javitch, J. A., Weinstein, H., Kobilka, B. K. & Blanchard, S. C., 2017, In: Nature. 547, 7661, p. 68–73

      Research output: Contribution to journalJournal articleResearchpeer-review

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