Michal Tomasz Marzec

Michal Tomasz Marzec

Associate Professor


  1. 2020
  2. Published

    In silico approach to predict pancreatic β-cells classically secreted proteins

    Pinheiro-Machado, E., Sandberg, T. O. M., Pihl, C., Hägglund, Per Mårten & Marzec, Michal Tomasz, 1 Jan 2020, In : Bioscience Reports. 40, 2, 13 p., BSR20193708.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production

    Argon, Y., Bresson, Sophie Emilie, Marzec, Michal Tomasz & Grimberg, A., 2020, In : Cells. 9, 8, 12 p., 1844.

    Research output: Contribution to journalReviewResearchpeer-review

  4. E-pub ahead of print

    Immunometabolism in type 2 diabetes mellitus: tissue-specific interactions

    Pinheiro-Machado, E., Convey, E. G. & Marzec, Michal Tomasz, 2020, In : Archives of Medical Science.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    The inducible beta 5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient beta-cells and is overexpressed in type 2 diabetes pancreatic islets

    Khilji, M. S., Bresson, Sophie Emilie, Verstappen, D., Pihl, C., Andersen, Phillip Alexander Keller, Agergaard, Jette Bach, Dahlby, T., Bryde, Tenna Holgersen, Klindt, K., Nielsen, C. K., Walentinsson, A., Zivkovic, D., Bousquet, M., Tyrberg, B., Richardson, S. J., Morgan, N. G., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2020, In : American Journal of Physiology: Endocrinology and Metabolism. 318, 6, p. E892-E900

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β

    Khilji, M. S., Verstappen, D., Dahlby, T., Prause, Michala Cecilie Burstein, Pihl, C., Bresson, Sophie Emilie, Bryde, Tenna Holgersen, Andersen, Phillip Alexander Keller, Klindt, K., Zivkovic, D., Bousquet-Dubouch, M. P., Tyrberg, B., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2020, In : PLoS ONE. 15, 2, 21 p., e0222432.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2019
  8. Published

    Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

    Ghiasi, S. M., Dahlby, T., Hede Andersen, C., Haataja, L., Petersen, S., Omar-Hmeadi, M., Yang, M., Pihl, C., Bresson, Sophie Emilie, Khilji, M. S., Klindt, K., Cheta, O., Perone, M. J., Tyrberg, B., Prats, C., Barg, S., Tengholm, A., Arvan, P., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, Apr 2019, In : Diabetes. 68, 4, p. 747-760 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    MCPIP1 regulates insulin biosynthesis and glucose-stimulated insulin secretion: [Meeting Abstract]

    Tyka, K., Brydde, T. H., Wilamowski, M., Jura, J., Marzec, Michal Tomasz & Gurgul-Convey, E., 2019, In : FEBS Open Bio. 9, S1, p. 87-87 P-01-064.

    Research output: Contribution to journalConference abstract in journalResearch

  10. 2018
  11. Published

    Students’ supervision and introduction during the initial period in the research laboratory: does it matter?

    Marzec, Michal Tomasz, 2018, Improving University Science Teaching and Learning: Pedagogical Projects 2018. Department of Science Education, University of Copenhagen, Denmark, p. 107-114 8 p. (Improving University Science Teaching and Learning - Pedagogical Projects, Vol. 12).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  12. 2017
  13. Unexpected profile of sphingolipid contents in blood and bone marrow plasma collected from patients diagnosed with acute myeloid leukemia

    WAtek, M., Wollny, T., Pasiarski, M., Gozdz, S., Durnas, B., Wolak, P., Bucki, R., Marzec, Michal Tomasz, Chabowska, A. & Zendzian-Piotrowska, M., 2017, In : Lipids in Health and Disease. 16, 1

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2016
  15. Published

    A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production

    Marzec, Michal Tomasz, Hawkes, C. P., Eletto, D., Boyle, S., Rosenfeld, R. G., Hwa, V., Wit, J. M., van Duyvenvoorde, H. A., Oostdijk, W., Losekoot, M., Pedersen, Oluf Borbye, Yeap, B. B., Flicker, L., Barzilai, N., Atzmon, G., Grimberg, A. & Argon, Y., May 2016, In : Endocrinology. 157, 5, p. 1914-1928 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Utility of blood procalcitonin concentration in the management of cancer patients with infections

    Durnas, B., Watek, M., Wollny, T., Niemirowicz, K., Marzec, Michal Tomasz, Bucki, R. & Gozdz, S., 2016, In : OncoTargets and Therapy. 9, p. 469-475

    Research output: Contribution to journalReviewResearchpeer-review

  17. 2014
  18. Variation in GRP94 Activity Impacts Production of Igfs and Human Growth

    Argon, Y., Grimberg, A., Rosenfeld, R. G. & Marzec, Michal Tomasz, 2014, In : Endocrine Reviews. 35, 3

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2013
  20. Published

    Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming

    Marzec, Michal Tomasz, Halasa, K., Liu, X., Wang, H. Y., Cheng, M., Baldwin, D., Tobias, J. W., Schuster, S. J., Woetmann, Anders , Zhang, Q., Turner, S. D., Ødum, Niels & Wasik, M. A., 15 Dec 2013, In : Journal of immunology (Baltimore, Md. : 1950). 191, 12, p. 6200-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma.

    Lee, S., Marzec, Michal Tomasz, Liu, X., Wehrli, S., Kantekure, K., Ragunath, P. N., Nelson, D. S., Delikatny, E. J., Glickson, J. D. & Wasik, M. A., 2013, In : NMR in Biomedicine. 26, 1, p. 106-114 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2012
  23. GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

    Marzec, Michal Tomasz, Eletto, D. & Argon, Y., Mar 2012, In : B B A - Reviews on Cancer. 1823, 3, p. 774-87 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Prediction and Early Detection of Response by NMR Spectroscopy and Imaging

    Lee, S., Arias-Mendoza, F., Poptani, H., Delikatny, E. J., Wasik, M., Marzec, Michal Tomasz, Schuster, S. J., Nasta, S. D., Svoboda, J., O'Connor, O. A., Smith, M. R. & Glickson, J. D., Jan 2012, In : PET Clinics. 7, 1, p. 119-26 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2011
  26. Published

    Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells

    Marzec, Michal Tomasz, Liu, X., Wysocka, M., Rook, A. H., Ødum, Niels & Wasik, M. A., 16 Sep 2011, In : PLoS ONE. 6, 9, 8 p., e24849.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Oncogenic kinase NPM/ALK induces expression of HIF1 alpha mRNA

    Marzec, Michal Tomasz, Liu, X., Wong, W., Yang, Y., Pasha, T., Kantekure, K., Zhang, P., Woetmann, Anders , Cheng, M., Ødum, Niels & Wasik, M. A., 2011, In : Oncogene. 30, 11, p. 1372-1378 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2010
  29. Plasma gelsolin modulates cellular response to sphingosine 1-phosphate

    Bucki, R., Kulakowska, A., Byfield, F. J., Zendzian-Piotrowska, M., Baranowski, M., Marzec, Michal Tomasz, Winer, J. P., Ciccarelli, N. J., Gorski, J., Drozdowski, W., Bittman, R. & Janmey, P. A., 2010, In : American Journal of Physiology: Cell Physiology. 299, 6, p. C1516-23

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2009
  31. Activation of mTORC1 signaling pathway in AIDS-related lymphomas.

    El-Salem, M., Raghunath, P. N., Marzec, Michal Tomasz, Liu, X., Kasprzycka, M., Robertson, E. & Wasik, M. A., 2009, In : American Journal of Pathology. 175, 2, p. 817-824 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches

    Wasik, M. A., Zhang, Q., Marzec, Michal Tomasz, Kasprzycka, M., Wang, H. Y. & Liu, X., 2009, In : Seminars in Oncology. 36, 2 Suppl 1, p. S27-35

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2008
  34. Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

    Marzec, Michal Tomasz, Zhang, Q., Goradia, A., Raghunath, P. N., Liu, X., Paessler, M., Wang, H. Y., Wysocka, M., Cheng, M., Ruggeri, B. A. & Wasik, M. A., 30 Dec 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20852-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4(+) T lymphocytes

    Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, Michal Tomasz, Potoczek, M., Liu, X., Wang, H. Y., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Ødum, Niels & Wasik, M. A., 15 Aug 2008, In : Journal of Immunology. 181, 4, p. 2506-2512

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Expression of FOXP3(+) regulatory T-cell phenotype in neoplastic and reactive cells in early mycosis fungoides

    Witkiewicz, A. K., Potoczek, M., Kasprzycka, M., Marzec, Michal Tomasz & Wasik, M., Jan 2008, In : Modern Pathology. 21, p. 103A-103A

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Differential Effects of Interleukin-2 and Interleukin-15 versus Interleukin-21 on CD4+ Cutaneous T-Cell Lymphoma Cells

    Marzec, Michal Tomasz, Halasa, K., Kasprzycka, M., Wysocka, M., Liu, X., Tobias, J. W., Baldwin, D., Zhang, Q., Ødum, Niels, Rook, A. H. & Wasik, M. A., 2008, In : Cancer Research. 68, 4, p. 1083-91 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes

    Marzec, Michal Tomasz, Liu, X., Kasprzycka, M., Witkiewicz, A., Raghunath, P. N., El-Salem, M., Robertson, E., Ødum, Niels & Wasik, M. A., 2008, In : Blood. 111, 4, p. 2181-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    γc-Signaling Cytokines Induce a Regulatory T Cell Phenotype in Malignant CD4+ T Lymphocytes.

    Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, Michal Tomasz, Potoczek, M., Liu, X., Wang, H. Y., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Ødum, Niels & Wasik, M. A., 2008, In : Journal of Immunology. 181, 4, p. 2506-2512 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2007
  41. Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders.

    El-Salem, M., Raghunath, P. N., Marzec, Michal Tomasz, Wlodarski, P., Tsai, D., Hsi, E. & Wasik, M. A., 2007, In : Laboratory Investigation. 87, 1, p. 29-39 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.

    Marzec, Michal Tomasz, Kasprzycka, M., Liu, X., Raghunath, P. N., Wlodarski, P. & Wasik, M. A., 2007, In : Oncogene. 26, 6, p. 813-821 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

    Marzec, Michal Tomasz, Kasprzycka, M., Liu, X., El-Salem, M., Halasa, K., Raghunath, P. N., Bucki, R., Wlodarski, P. & Wasik, M. A., 2007, In : Oncogene. 26, 38, p. 5606-5614 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

    Wlodarski, P., Zhang, Q., Liu, X., Kasprzycka, M., Marzec, Michal Tomasz & Wasik, M. A., 2007, In : Journal of Biological Chemistry. 282, 9, p. 6316-6323 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2006
  46. Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity

    Marzec, Michal Tomasz, Kasprzycka, M., Lai, R., Gladden, A. B., Wlodarski, P., Tomczak, E., Nowell, P., DePrimo, S. E., Sadis, S., Eck, S., Schuster, S. J., Diehl, J. A. & Wasik, M. A., 1 Sep 2006, In : Blood. 108, 5, p. 1744-1750

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3

    Kasprzycka, M., Marzec, Michal Tomasz, Liu, X., Zhang, Q. & Wasik, M. A., 27 Jun 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 26, p. 9964-9969

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

    Kasprzycka, M., Majewski, M., Wang, Z., Ptasznik, A., Wysocka, M., Zhang, Q., Marzec, Michal Tomasz, Gimotty, P., Crompton, M. R. & Wasik, M. A., 2006, In : American Journal of Pathology. 168, 5, p. 1631-1641 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Jak3 contributes to the activation of ALK and Stat3 in ALK + anaplastic large cell lymphoma. Response.

    Wasik, M. A. & Marzec, Michal Tomasz, 2006, In : Laboratory Investigation. 86, 4, p. 420-421 2 p.

    Research output: Contribution to journalLetterResearch

  50. Published

    Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing

    Nagasawa, T., Zhang, Q., Raghunath, P. N., Wong, H. Y., El-Salem, M., Szallasi, A., Marzec, Michal Tomasz, Gimotty, P., Rook, A. H., Vonderheid, E. C., Ødum, Niels & Wasik, M. A., 2006, In : Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 30, 3, p. 303-12 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Peroxisome Proliferator-Activated Receptor γ Promotes Lymphocyte Survival through Its Actions on Cellular Metabolic Activities.

    Jo, S., Yang, C., Miao, Q., Marzec, Michal Tomasz, Wasik, M. A., Lu, P. & Wang, Y. L., 2006, In : Journal of Immunology. 177, 6, p. 3737-3745 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2005
  53. Activation of Mammalian Target of Rapamycin in Transformed B Lymphocytes Is Nutrient Dependent but Independent of Akt, Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase, Insulin Growth Factor-I, and Serum.

    Wlodarski, P., Kasprzycka, M., Liu, X., Marzec, Michal Tomasz, Robertson, E. S., Slupianek, A. & Wasik, M. A., 2005, In : Cancer Research. 65, 17, p. 7800-7808 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3

    Marzec, Michal Tomasz, Kasprzycka, M., Ptasznik, A., Wlodarski, P., Zhang, Q., Ødum, Niels & Wasik, M. A., 2005, In : Laboratory Investigation. 85, 12, p. 1544-54 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.

    Zhang, Q., Wang, H. Y., Marzec, Michal Tomasz, Raghunath, P. N., Nagasawa, T. & Wasik, M. A., 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 19, p. 6948-6953 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 129941679